Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Skeletal Radiology
Published in: Skeletal Radiology 5/2005

01-05-2005 | Scientific Article

Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors

Authors: M. J. Panzarella, A. H. Naqvi, H. E. Cohen, T. A. Damron

Published in: Skeletal Radiology | Issue 5/2005

Login to get access

Abstract

Objective

To determine the predictive value of gadolinium enhancement on MRI in differentiating atypical lipomatous tumor (ALT)/well-differentiated (WD) liposarcoma from benign fatty tumors.

Design

All histologically proven fatty tumors with preoperative gadolinium-enhanced MRI were reviewed. Only those tumors with predominantly fatty signal were included. Sensitivity, specificity, and positive and negative predictive values for both gadolinium enhancement and biopsy as predictors for the final diagnosis of ALT/WD liposarcoma were calculated.

Patients

From 129 patients evaluated for fatty tumors between 1994 and 2002, the patient population was narrowed to 32 excised fatty tumors with preoperative gadolinium-enhanced MRI.

Results

As a predictor of ALT/WD liposarcoma, the presence of gadolinium enhancement showed 100% sensitivity, 71% specificity, 53% positive predictive value and 100% negative predictive value. Needle or incisional biopsy yielded 57% sensitivity, 100% specificity, 100% positive predictive value and 63% negative predictive value for a diagnosis of ALT/WD liposarcoma.

Conclusions

Gadolinium enhancement of a homogeneous fatty soft tissue tumor is a sensitive screening tool to determine possible diagnosis of ALT/WD liposarcoma. Biopsy, on the other hand, is specific but insensitive.
Literature
1.
Einarsdottir H, Soderlund V, Larson O, Jenner G, Bauer HCF. MR Imaging of lipoma and liposarcoma. Acta Radiol 1999; 40:64–68.PubMed
2.
Gelineck J, Keller J, Myhre Jensen O, Steen Nielsen O, Christensen T. Evaluation of lipomatous soft tissue tumors by MR IMAGING. Acta Radiol 1994; 35:367–370.
3.
Hosono M, Kobayashi H, Fujimoto R, et al. Septum-like structures in lipoma and liposarcoma: MR imaging and pathologic correlation. Skeletal Radiol 1997; 26:150–154.
4.
Matsumoto K, Hukuda S, Ishizawa M, Chano T, Okabe H. MRI findings in intramuscular lipomas. Skeletal Radiol 1999; 28:145–152.
5.
Arkun R, Memis A, Aklin T, Ustunn EE, Sabah D, Kandiloglu GR. Liposarcoma of soft tissue: MRI findings with pathologic correlation. Skeletal Radiol 1997; 26:167–172.CrossRefPubMed
6.
Yang YJ, Damron TA, Cohen H, Hojnowski L. Distinction of well-differentiated liposarcoma from lipoma in two patients with multiple well-differentiated fatty masses. Skeletal Radiol 1997; 30:584–589.
7.
Kindblom L, Angervall L, Fassina A. Atypical lipoma. Acta Pathol Microbiol Immunol Scand 1982; 90:27–36.
8.
Mentzel T, Fletcher CDM. Lipomatous tumors of soft tissues: an update. Virchows Arch 1995; 427:353–363.PubMed
9.
Weiss SW, Rao VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum and miscellaneous sites. Am J Surg Pathol 1992; 16:1051–1058.PubMed
10.
Evans HL. Liposarcomas and atypical lipomatous tumors: a study of 66 cases followed for a minimum of 10 years. Surg Pathol 1998; 1:41–54.
11.
Lucas DR, Nascimento AG, Sanjay BKS, Rock MG. Well-differentiated liposarcoma. Am J Clin Pathol 1994; 102:677–683.
12.
Rozental TD, Khoury LD, Donthineni-Rao R, Lackman RD. Atypical masses of the extremities: outcome of surgical treatment. Clinical Orthop 2002; 398:203–211.
13.
Weiss SW, Goldblum JR. Enziger and Weiss’ soft tissue tumors, 4th edn. St Luis: Mosby-Year Book, 2001:576–578, 624–625.
14.
Evans HL, Soule EH, Winkelmann RK. Atypical lipomas, atypical intramuscular lipomas, and well differentiated retroperitoneal liposarcoma. Cancer 1979; 43:574–584.
15.
Rougraff BT, Durbin M, Lawrence J, Buckwalter K. Histologic correlation with magnetic resonance imaging for benign and malignant lipomatous masses. Sarcoma 1997; 1:175–179.
16.
Kransdorf MJ, Murphy MD. Imaging of soft tissue tumors. Philadelphia: WB Saunders, 1997:41–42.
17.
Preul MC, Tampieri D, Robitaille Y, Pokrupa R. Spinal angiolipomas: report of three cases. J Neurosurg 1993; 78:280–286.
Metadata
Title
Predictive value of gadolinium enhancement in differentiating ALT/WD liposarcomas from benign fatty tumors
Authors
M. J. Panzarella
A. H. Naqvi
H. E. Cohen
T. A. Damron
Publication date
01-05-2005
Publisher
Springer-Verlag
Published in
Skeletal Radiology / Issue 5/2005
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI
https://doi.org/10.1007/s00256-004-0884-5

Other articles of this Issue 5/2005

Skeletal Radiology 5/2005 Go to the issue

Case Report

Ewing’s sarcoma of the humerus mimicking fibrous dysplasia on imaging and biological behavior

Case Report

Erdheim-Chester disease in a child with MR imaging showing regression of marrow changes

Scientific Article

Acromioclavicular joint cyst: nine cases of a pseudotumor of the shoulder

Scientific Article

Harris lines of the tibia across centuries: a comparison of two populations, medieval and contemporary in Central Europe

Case Report

Soft tissue telangiectatic osteosarcoma in a young patient: imaging and immunostains

Review Article

Distinguishing stress fractures from pathologic fractures: a multimodality approach