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01-05-2005 | Case Report

Soft tissue telangiectatic osteosarcoma in a young patient: imaging and immunostains

Authors: Vorachai Sirikulchayanonta, Suphaneewan Jaovisidha

Published in: Skeletal Radiology | Issue 5/2005

Abstract

Telangiectatic osteosarcoma of the soft tissue is rare and generally affects adults older than 50 years of age. We present the case of a 17-year-old male who developed a mass in the right thigh. The CT and MRI findings suggested a malignant hemorrhagic tumor without discernable osteoid matrix. Differential diagnosis included various hemorrhagic mesenchymal tumors. Histology revealed large multiple cysts lined with septae and filled with numerous giant cells, pleomorphic spindle cells, and occasionally an osteoid-like substance. Immunostaining for osteocalcin was positive in the cytoplasm of both stromal mononucleate and multinucleate giant cells. Surgery and adjuvant chemotherapy were applied and the patient survives to the time of writing after 30 months of follow-up without recurrence or metastasis.

Sordillo PP, Hajdu SI, Magill GB et al. Extraosseous osteogenic sarcoma: a review of 48 patients. Cancer 1983; 51:727–734.PubMed

Bacetic D, Knezevic M, Stojsic Z, Atanackovic M, Vujanic GM. Primary extraskeletal osteosarcoma of the penis with a malignant fibrous histiocytoma-like component. Histopathology 1998; 33:185–186.CrossRefPubMed

Lorentzon R, Larsson SE, Bequist L. Extraosseous osteosarcoma: a clinical and histopathological study of four cases. J Bone Joint Surg Br 1979; 61:205–208.

Meis-Kindblom JM, Enzinger FM. Extraskeletal osteosarcoma. In: Meis-Kindblom JM, Enzinger FM, eds. Color atlas of soft tissue tumors. St. Louis: Mosby-Wolfe, 1996: 270.

Rosenberg AE, Heim, S. Extraskeletal osteosarcoma. In: Fletcher CDM, Unni KK, Mertens F, eds. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press, 2002: 182–183.

Chung EB, Enzinger FM. Extraskeletal osteosarcoma. Cancer 1987; 60:1132–1142.PubMed

Mirra JM, Fain JS, Ward WG et al. Extraskeletal telangiectatic osteosarcoma. Cancer 1993; 71:3014–3019.

Dubec JJ, Munk PL, O’Connell JX et al. Soft tissue osteosarcoma with telangiectatic features: MR imaging findings in two cases. Skeletal Radiol 1997; 26:732–736.CrossRefPubMed

Tsai JC, Dalinka MK, Fallon MD et al. Fluid–fluid level: a nonspecific finding in tumors of bone and soft tissue. Radiology 1990; 175:779–782.PubMed

10.

Sone M, Ehara S, Sasaki M et al. Fluid–fluid levels in bone and soft tissue tumors demonstrated by MR imaging. Nippon Igaku Hoshasen Gakkai Zasshi 1992; 52:1110–1115.PubMed

11.

Kransdorf MJ, Meis JM. Extraskeletal osseous and cartilaginous tumors of the extremities. Radiographics 1993; 13:853–884.PubMed

12.

Sharaffuddin MJA, Sundaram M. The role of magnetic resonance imaging in the diagnosis of soft tissue lesions. Crit Rev Diagn Imaging 1994; 35:379–483.PubMed

13.

Murphey MD, wan Jaovisidha S, Temple HT et al. Telangiectatic osteosarcoma: radiologic–pathologic comparison. Radiology 2003; 229:545–553.PubMed

14.

Varma DGK, Ayala AG, Guo SQ et al. MRI of extraskeletal osteosarcoma. J Comput Assist Tomogr 1993; 17:414–417.PubMed

15.

Iwasaki R, Yamamuro T, Kotoura Y, Okumura H, Kasai R, Nakashima Y. Immunohistochemical study of bone GLA protein in primary bone tumors. Cancer 1992; 70:619–624.

16.

Chano T, Matsumoto K, Ishizawa M et al. Analysis of the presence of osteocalcin, S-100 protein and proliferating cell nuclear antigen in cells of various types of osteosarcomas. Eur J Histochem 1996; 40:189–198.PubMed

17.

Fanburg-Smith JC, Bratthauer GL, Miettinen M. Osteocalcin and osteonectin immunoreactivity in extraskeletal osteosarcoma: a study of 28 cases. Hum Pathol 1999; 30:32–38.CrossRefPubMed

18.

Bane BL, Evans HL, Ro JY et al. Extraskeletal osteosarcoma. A clinicopathologic review of 26 cases. Cancer 1990; 65:2762–2770.PubMed

19.

Hasgawa T, Hirose T, Kudo E et al. Immunophenotypic heterogeneity in osteosarcoma. Hum Pathol 1991; 22:583–590.CrossRefPubMed

20.

Lee JSY, Fetsch JF, Wasdhal DA et al. A review of 40 patients with extraskeletal osteosarcoma. Cancer 1995; 76:2253–2259.PubMed

Title: Soft tissue telangiectatic osteosarcoma in a young patient: imaging and immunostains
Authors: Vorachai Sirikulchayanonta
Suphaneewan Jaovisidha
Publication date: 01-05-2005
Publisher: Springer-Verlag
Published in: Skeletal Radiology / Issue 5/2005
Print ISSN: 0364-2348
Electronic ISSN: 1432-2161
DOI: https://doi.org/10.1007/s00256-004-0844-0

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Soft tissue telangiectatic osteosarcoma in a young patient: imaging and immunostains

Abstract

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