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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2017

Open Access 01-12-2017 | Research article

Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review

Authors: Noémie Gensous, Aurélie Marti, Thomas Barnetche, Patrick Blanco, Estibaliz Lazaro, Julien Seneschal, Marie-Elise Truchetet, Pierre Duffau, Christophe Richez, on behalf of the FHU ACRONIM

Published in: Arthritis Research & Therapy | Issue 1/2017

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Abstract

Background

The aim of this study was to identify the most reliable biomarkers in the literature that could be used as flare predictors in systemic lupus erythematosus (SLE).

Methods

A systematic review of the literature was performed using two databases (MEDLINE and EMBASE) through April 2015 and congress abstracts from the American College of Rheumatology and the European League Against Rheumatism were reviewed from 2010 to 2014. Two independent reviewers screened titles and abstracts and analysed selected papers in detail, using a specific questionnaire. Reports addressing the relationships between one or more defined biological test(s) and the occurrence of disease exacerbation were included in the systematic review.

Results

From all of the databases, 4668 records were retrieved, of which 69 studies or congress abstracts were selected for the systematic review. The performance of seven types of biomarkers performed routinely in clinical practice and nine types of novel biological markers was evaluated. Despite some encouraging results for anti-double-stranded DNA antibodies, anti-C1q antibodies, B-lymphocyte stimulator and tumour necrosis factor-like weak inducer of apoptosis, none of the biomarkers stood out from the others as a potential gold standard for flare prediction. The results were heterogeneous, and a lack of standardized data prevented us from identifying a powerful biomarker.

Conclusions

No powerful conclusions could be drawn from this systematic review due to a lack of standardized data. Efforts should be undertaken to optimize future research on potential SLE biomarkers to develop validated candidates. Thus, we propose a standardized pattern for future studies.
Appendix
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Metadata
Title
Predictive biological markers of systemic lupus erythematosus flares: a systematic literature review
Authors
Noémie Gensous
Aurélie Marti
Thomas Barnetche
Patrick Blanco
Estibaliz Lazaro
Julien Seneschal
Marie-Elise Truchetet
Pierre Duffau
Christophe Richez
on behalf of the FHU ACRONIM
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2017
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/s13075-017-1442-6

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