Skip to main content
Top
Published in: Archives of Gynecology and Obstetrics 4/2015

Open Access 01-10-2015 | Position Statements and Guidelines

Predicting formation of adhesions after gynaecological surgery: development of a risk score

Authors: Per Lundorff, Hans Brölmann, Philippe Robert Koninckx, Michal Mara, Arnaud Wattiez, Markus Wallwiener, Geoffrey Trew, Alison M. Crowe, Rudy Leon De Wilde, For the Anti-Adhesions in Gynaecology Expert Panel (‘ANGEL’)

Published in: Archives of Gynecology and Obstetrics | Issue 4/2015

Login to get access

Abstract

Purpose

Risk factors for post-surgical adhesions following gynaecological surgery have been identified, but their relative importance has not been precisely determined. No practical tool exists to help gynaecological surgeons evaluate the risk of adhesions in their patients. The purpose of the study was to develop an Adhesion Risk Score to provide a simple tool that will enable gynaecological surgeons to routinely quantify the risk of post-surgical adhesions in individual patients.

Methods

A group of European gynaecological surgeons searched the literature to identify the risk factors and the surgical operations reported as carrying a risk of post-surgical adhesions. Through consensus process of meetings and communication, a four-point scale was then used by each surgeon to attribute a specific weight to each item and collective agreement reached on identified risk factors and their relative importance to allow construct of a useable risk score.

Results

Ten preoperative and 10 intraoperative risk factors were identified and weighed, leading to the creation of two sub-scores to identify women at risk prior to and during surgery. The Preoperative Risk Score can range from 0 to 36, and the Intraoperative Risk Score from 3 to 31. Several thresholds between these limits may be used to identify women with low, medium, and high risk of post-surgical adhesions.

Conclusions

Gynaecological surgeons are encouraged to use this Adhesion Risk Score to identify the risk of adhesions in their patients. This will allow better informed use of available resources to target preventive measures in women at high risk of post-surgical adhesions.
Literature
1.
go back to reference Monk BJ, Berman ML, Montz FJ (1994) Adhesions after extensive gynecologic surgery: clinical significance, etiology and prevention. Am J Obstet Gynecol 170:1396–1403CrossRefPubMed Monk BJ, Berman ML, Montz FJ (1994) Adhesions after extensive gynecologic surgery: clinical significance, etiology and prevention. Am J Obstet Gynecol 170:1396–1403CrossRefPubMed
2.
go back to reference Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL (2001) Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 18:260–273CrossRefPubMed Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL (2001) Peritoneal adhesions: etiology, pathophysiology, and clinical significance. Recent advances in prevention and management. Dig Surg. 18:260–273CrossRefPubMed
3.
go back to reference van der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MMPJ, Schaapveld M, van Goor H (2000) Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg 87:467–471CrossRef van der Krabben AA, Dijkstra FR, Nieuwenhuijzen M, Reijnen MMPJ, Schaapveld M, van Goor H (2000) Morbidity and mortality of inadvertent enterotomy during adhesiotomy. Br J Surg 87:467–471CrossRef
4.
go back to reference Swank DJ, Swank-Bordewijk SCG, Hop WCJ, van Erp WFM, Janssen IMC, Bonjer HJ, Jeekel J (2003) Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial. Lancet 361:1247–1251CrossRefPubMed Swank DJ, Swank-Bordewijk SCG, Hop WCJ, van Erp WFM, Janssen IMC, Bonjer HJ, Jeekel J (2003) Laparoscopic adhesiolysis in patients with chronic abdominal pain: a blinded randomised controlled multi-centre trial. Lancet 361:1247–1251CrossRefPubMed
5.
go back to reference Hershlag A, Diamond MP, DeCherney AH (1991) Adhesiolysis. Clin Obstet Gynaecol 34:395–402CrossRef Hershlag A, Diamond MP, DeCherney AH (1991) Adhesiolysis. Clin Obstet Gynaecol 34:395–402CrossRef
6.
go back to reference Mishell DR, Davajan V (1991) Evaluation of the infertile couple. In: Mishell DR Jr, Davajan V, Lobo RA (eds) Infertility contraception and reproductive endocrinology, 3rd edn. Blackwell Scientific, Boston, pp 557–570 Mishell DR, Davajan V (1991) Evaluation of the infertile couple. In: Mishell DR Jr, Davajan V, Lobo RA (eds) Infertility contraception and reproductive endocrinology, 3rd edn. Blackwell Scientific, Boston, pp 557–570
7.
go back to reference Diamond MP, Freeman ML (2001) Clinical implications of postsurgical adhesions. Hum Reprod Update 7:567–576CrossRefPubMed Diamond MP, Freeman ML (2001) Clinical implications of postsurgical adhesions. Hum Reprod Update 7:567–576CrossRefPubMed
8.
go back to reference Kössi J, Salminen P, Rantala A, Laato M (2003) Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions. Br J Surg 90:1441–1444CrossRefPubMed Kössi J, Salminen P, Rantala A, Laato M (2003) Population-based study of the surgical workload and economic impact of bowel obstruction caused by postoperative adhesions. Br J Surg 90:1441–1444CrossRefPubMed
9.
go back to reference Brüggmann D, Tchartchian G, Wallwiener M, Münstedt K, Tinneberg HR, Hackethal A (2010) Intra-abdominal adhesions: Definition, origin, significance in surgical practice, and treatment options. Dtsch Arztebl Int. 107:769–775PubMedCentralPubMed Brüggmann D, Tchartchian G, Wallwiener M, Münstedt K, Tinneberg HR, Hackethal A (2010) Intra-abdominal adhesions: Definition, origin, significance in surgical practice, and treatment options. Dtsch Arztebl Int. 107:769–775PubMedCentralPubMed
10.
go back to reference Trew G, Pistofidis G, Pados G, Lower A, Mettler L, Wallwiener D et al (2011) Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery. Hum Reprod 26:2015–2027CrossRefPubMed Trew G, Pistofidis G, Pados G, Lower A, Mettler L, Wallwiener D et al (2011) Gynaecological endoscopic evaluation of 4% icodextrin solution: a European, multicentre, double-blind, randomized study of the efficacy and safety in the reduction of de novo adhesions after laparoscopic gynaecological surgery. Hum Reprod 26:2015–2027CrossRefPubMed
11.
go back to reference Nappi C, Di Spiezio Sardo A, Greco E, Guida M, Bettocchi S, Bifulco G (2007) Prevention of adhesions in gynaecologic endoscopy. Hum Reprod Update 13:379–394CrossRefPubMed Nappi C, Di Spiezio Sardo A, Greco E, Guida M, Bettocchi S, Bifulco G (2007) Prevention of adhesions in gynaecologic endoscopy. Hum Reprod Update 13:379–394CrossRefPubMed
12.
go back to reference Lower AM, Hawthorn RJS, Clark D, Boyd JH, Finlayson AR, Knight AD, Crowe AM, Surgical and Clinical Research (SCAR) Group (2004) Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod 19:1877–1885CrossRefPubMed Lower AM, Hawthorn RJS, Clark D, Boyd JH, Finlayson AR, Knight AD, Crowe AM, Surgical and Clinical Research (SCAR) Group (2004) Adhesion-related readmissions following gynaecological laparoscopy or laparotomy in Scotland: an epidemiological study of 24 046 patients. Hum Reprod 19:1877–1885CrossRefPubMed
13.
go back to reference Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJS, O’Brien F, Buchan S, Crowe AM (1999) Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet 353:1476–1480CrossRefPubMed Ellis H, Moran BJ, Thompson JN, Parker MC, Wilson MS, Menzies D, McGuire A, Lower AM, Hawthorn RJS, O’Brien F, Buchan S, Crowe AM (1999) Adhesion-related hospital readmissions after abdominal and pelvic surgery: a retrospective cohort study. Lancet 353:1476–1480CrossRefPubMed
14.
go back to reference Lower AM, Hawthorn RJS, Ellis H, The Late O’Brien F, Buchan S, Crowe AM (2000) The impact of adhesions on hospital readmissions over ten years after 8489 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. Br J Obstet Gynaecol 2000(07):855–862CrossRef Lower AM, Hawthorn RJS, Ellis H, The Late O’Brien F, Buchan S, Crowe AM (2000) The impact of adhesions on hospital readmissions over ten years after 8489 open gynaecological operations: an assessment from the Surgical and Clinical Adhesions Research Study. Br J Obstet Gynaecol 2000(07):855–862CrossRef
15.
go back to reference DeWilde RL, Trew G, on behalf of the Expert Adhesions Working Party of the European Society of Gynaecological Endoscopy (ESGE) (2007) Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2—steps to reduce adhesions. Gynecol Surg 4:243–253 DeWilde RL, Trew G, on behalf of the Expert Adhesions Working Party of the European Society of Gynaecological Endoscopy (ESGE) (2007) Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Part 2—steps to reduce adhesions. Gynecol Surg 4:243–253
16.
go back to reference Sawada T, Nishizawa H, Nishio E, Kadowaki M (2000) Postoperative adhesion prevention with an oxidized regenerated cellulose adhesion barrier in infertile women. J Reprod Med 45:387–389PubMed Sawada T, Nishizawa H, Nishio E, Kadowaki M (2000) Postoperative adhesion prevention with an oxidized regenerated cellulose adhesion barrier in infertile women. J Reprod Med 45:387–389PubMed
17.
go back to reference Diamond MP; The Seprafilm Adhesion Study Group (1996) Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Fertil Steril 66:904–910 Diamond MP; The Seprafilm Adhesion Study Group (1996) Reduction of adhesions after uterine myomectomy by Seprafilm membrane (HAL-F): a blinded, prospective, randomized, multicenter clinical study. Fertil Steril 66:904–910
18.
go back to reference Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD et al (1996) Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg 183:297–306PubMed Becker JM, Dayton MT, Fazio VW, Beck DE, Stryker SJ, Wexner SD et al (1996) Prevention of postoperative abdominal adhesions by a sodium hyaluronate-based bioresorbable membrane: a prospective, randomized, double-blind multicenter study. J Am Coll Surg 183:297–306PubMed
19.
go back to reference Mais V, Cirronis MG, Peiretti M, Ferrucci G, Cossu E, Melis GB (2012) Efficacy of auto-crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and met-analysis of randomised controlled trials. Eur J Obstet Gynecol Reprod Biol 160:1–5CrossRefPubMed Mais V, Cirronis MG, Peiretti M, Ferrucci G, Cossu E, Melis GB (2012) Efficacy of auto-crosslinked hyaluronan gel for adhesion prevention in laparoscopy and hysteroscopy: a systematic review and met-analysis of randomised controlled trials. Eur J Obstet Gynecol Reprod Biol 160:1–5CrossRefPubMed
20.
go back to reference Brown CB, Luciano AA, Martin D, Peers E, Scrimgeour A, diZerega GS, on behalf of the Adept Adhesion Reduction Study Group (2007) Adept (icodextrin 4 % solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a doubleblind, randomized, controlled study. Fertil Steril. doi:10.1016/j.fertnstert.2006.12.084 PubMedCentral Brown CB, Luciano AA, Martin D, Peers E, Scrimgeour A, diZerega GS, on behalf of the Adept Adhesion Reduction Study Group (2007) Adept (icodextrin 4 % solution) reduces adhesions after laparoscopic surgery for adhesiolysis: a doubleblind, randomized, controlled study. Fertil Steril. doi:10.​1016/​j.​fertnstert.​2006.​12.​084 PubMedCentral
21.
go back to reference Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D et al (2001) Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Dis Colon Rectum 44:822–830CrossRefPubMed Parker MC, Ellis H, Moran BJ, Thompson JN, Wilson MS, Menzies D et al (2001) Postoperative adhesions: ten-year follow-up of 12,584 patients undergoing lower abdominal surgery. Dis Colon Rectum 44:822–830CrossRefPubMed
22.
go back to reference Parker MC, Wilson MS, Menzies D, Sunderland G, Thompson JN, Clark DN, Knight AD, Crowe AM, on behalf of the Surgical and Clinical Adhesions Research (SCAR) Group. (2004) Colorectal surgery: the risk and burden of adhesion-related complications. Colorectal Dis 6:506–511 Parker MC, Wilson MS, Menzies D, Sunderland G, Thompson JN, Clark DN, Knight AD, Crowe AM, on behalf of the Surgical and Clinical Adhesions Research (SCAR) Group. (2004) Colorectal surgery: the risk and burden of adhesion-related complications. Colorectal Dis 6:506–511
23.
go back to reference Parker MC, Wilson MS, Menzies D, Sunderland G, Clark DN, Knight AD, Crowe AM, on behalf of the SCAR Group (2005) 5-year adhesion-related readmission risk following lower abdominal surgical procedures. Colorectal Dis 7:551–558 Parker MC, Wilson MS, Menzies D, Sunderland G, Clark DN, Knight AD, Crowe AM, on behalf of the SCAR Group (2005) 5-year adhesion-related readmission risk following lower abdominal surgical procedures. Colorectal Dis 7:551–558
24.
go back to reference Trew G, Lower A (2004) Consensus in adhesion reduction management. Obstet Gynaecol 6:S1–S16 Trew G, Lower A (2004) Consensus in adhesion reduction management. Obstet Gynaecol 6:S1–S16
25.
go back to reference Rimbach S, Korell M, Tinneberg HR, DeWilde RL (2004) Adhesions and their prevention in gynaecologic surgery: current status and consensus based on four workshops. Geburtsh Frauenheilk 64:891–899CrossRef Rimbach S, Korell M, Tinneberg HR, DeWilde RL (2004) Adhesions and their prevention in gynaecologic surgery: current status and consensus based on four workshops. Geburtsh Frauenheilk 64:891–899CrossRef
26.
go back to reference DeWilde RL, Trew G, on behalf of the Expert Adhesions Working Party of the European Society of Gynaecological Endoscopy (ESGE) (2007) Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Gynecol Surg 4:161–168 DeWilde RL, Trew G, on behalf of the Expert Adhesions Working Party of the European Society of Gynaecological Endoscopy (ESGE) (2007) Postoperative abdominal adhesions and their prevention in gynaecological surgery. Expert consensus position. Gynecol Surg 4:161–168
27.
go back to reference The Practice Committee of the ASRM (2006) Control and prevention of peritoneal adhesions in gynecologic surgery. Fertil Steril 86(Suppl 4):S1–S5 The Practice Committee of the ASRM (2006) Control and prevention of peritoneal adhesions in gynecologic surgery. Fertil Steril 86(Suppl 4):S1–S5
28.
go back to reference Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Society of Obstetricians and Gynaecologists of Canada et al (2010) Adhesion prevention in gynaecological surgery. J Obstet Gynaecol Can. 32:598–602PubMed Robertson D, Lefebvre G, Leyland N, Wolfman W, Allaire C, Awadalla A, Society of Obstetricians and Gynaecologists of Canada et al (2010) Adhesion prevention in gynaecological surgery. J Obstet Gynaecol Can. 32:598–602PubMed
30.
go back to reference Knightly JJ, Agostino D, Cliffton EE (1962) The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. Surgery 52:250–258PubMed Knightly JJ, Agostino D, Cliffton EE (1962) The effect of fibrinolysin and heparin on the formation of peritoneal adhesions. Surgery 52:250–258PubMed
32.
go back to reference Hackethal A, Sick C, Brueggmann D, Tchartchian G, Wallwiener M, Muenstedt K, Tinneberg HR (2010) Awareness and perception of intra-abdominal adhesions and related consequences: survey of gynaecologists in German hospitals. Eur J Obstet Gynecol Reprod Biol 150:180–189CrossRefPubMed Hackethal A, Sick C, Brueggmann D, Tchartchian G, Wallwiener M, Muenstedt K, Tinneberg HR (2010) Awareness and perception of intra-abdominal adhesions and related consequences: survey of gynaecologists in German hospitals. Eur J Obstet Gynecol Reprod Biol 150:180–189CrossRefPubMed
33.
go back to reference Wallwiener M, Koninckx PR, Hackethal A, Brölmann H, Lundorff P, Mara M, for The Anti-Adhesions in Gynecology Expert Panel (ANGEL) et al (2013) A European Survey on awareness of post-surgical adhesions among gynaecological surgeons. Gynecol Surg. doi:10.1007/s10397-013-0824-2 Wallwiener M, Koninckx PR, Hackethal A, Brölmann H, Lundorff P, Mara M, for The Anti-Adhesions in Gynecology Expert Panel (ANGEL) et al (2013) A European Survey on awareness of post-surgical adhesions among gynaecological surgeons. Gynecol Surg. doi:10.​1007/​s10397-013-0824-2
34.
go back to reference McGorrian C, Yusuf S, Islam S, Jung H, Rangarajan S, Avezum A et al (2011) Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score. Eur Heart J 32:581–590CrossRefPubMed McGorrian C, Yusuf S, Islam S, Jung H, Rangarajan S, Avezum A et al (2011) Estimating modifiable coronary heart disease risk in multiple regions of the world: the INTERHEART Modifiable Risk Score. Eur Heart J 32:581–590CrossRefPubMed
Metadata
Title
Predicting formation of adhesions after gynaecological surgery: development of a risk score
Authors
Per Lundorff
Hans Brölmann
Philippe Robert Koninckx
Michal Mara
Arnaud Wattiez
Markus Wallwiener
Geoffrey Trew
Alison M. Crowe
Rudy Leon De Wilde
For the Anti-Adhesions in Gynaecology Expert Panel (‘ANGEL’)
Publication date
01-10-2015
Publisher
Springer Berlin Heidelberg
Published in
Archives of Gynecology and Obstetrics / Issue 4/2015
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI
https://doi.org/10.1007/s00404-015-3804-0

Other articles of this Issue 4/2015

Archives of Gynecology and Obstetrics 4/2015 Go to the issue