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Open Access 01-12-2017 | Research

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

Authors: Marília Garcia de Oliveira, Luana de Mendonça Oliveira, Aline Aparecida de Lima Lira, Fábio da Ressureição Sgnotto, Alberto José da Silva Duarte, Maria Notomi Sato, Jefferson Russo Victor

Published in: Allergy, Asthma & Clinical Immunology | Issue 1/2017

Abstract

Background

The mechanisms through which allergies can be inhibited after preconception immunization with allergens are not fully understood. We aimed to evaluate whether maternal immunization can induce a regulatory B (B10) cell population in offspring in concert with allergy inhibition.

Methods

C57BL/6 females were or were not immunized with OVA and were mated with normal WT males. Their offspring were evaluated at 3 days of age or 20 days after neonatal immunization. Human peripheral B cells from atopic and non-atopic individuals were also evaluated.

Results

Preconception OVA immunization induced B10 cells in offspring, and IL-10 production appeared to be critical for FcγRIIB upregulation in offspring B cells. Murine and human IL-10-producing B cells responded in vitro to IgG according to the atopic repertoire of the cells.

Conclusions

Our results reveal that maternal immunization induces allergen-specific B10 cells in offspring and a pivotal role for the IgG repertoire in IL-10 production by murine and human B cells.

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Title: Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG
Authors: Marília Garcia de Oliveira
Luana de Mendonça Oliveira
Aline Aparecida de Lima Lira
Fábio da Ressureição Sgnotto
Alberto José da Silva Duarte
Maria Notomi Sato
Jefferson Russo Victor
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Allergy, Asthma & Clinical Immunology / Issue 1/2017
Electronic ISSN: 1710-1492
DOI: https://doi.org/10.1186/s13223-017-0195-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Preconception allergen sensitization can induce B10 cells in offspring: a potential main role for maternal IgG

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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