Top

Magnetic Resonance Materials in Physics, Biology and Medicine

Published in:

01-06-2019 | Research Article

Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters

Authors: Svein Are Sirirud Vatnehol, Per Kristian Hol, Atle Bjørnerud, Mahmood Amiry-Moghaddam, Camilla Haglerød, Tryggve Holck Storås

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 3/2019

Abstract

Objective

To investigate the effects of a range of parameter settings on T₁ measurement stability in the portal vein using the T1-mapping sequences Look-Locker (LL) and Modified Look-Locker inversion recovery (MOLLI).

Materials and methods

Ten different versions of LL and MOLLI sequences were tested and compared to a reference sequence provided by the MR manufacturer. Ten healthy volunteers were imaged multiple times on two separate scan days at 3T. The mean T₁ values and coefficient of variation (CoV) were calculated for each of the ten sequences and compared to the reference sequence.

Results

Six of the tested sequences had T₁ values close to the reference sequence; among those, three sequences achieved lower CoV than the reference sequence. Lowest CoV was achieved using a non-triggered LL sequence with 5 beat readout and a 45^o flip angle (mean T₁ 1733 ms ± 89 ms, CoV 1.3% ± 0.58%).

Conclusion

T₁-measurements in the hepatic portal vein can be performed with high precision using either MOLLI or LL sequences provided that LL sampling duration is sufficiently long and flip angle sufficiently high. The advantage of constant timing outweighed the advantage of ECG-triggering.

Available only for authorised users

Ganong WF (1999) Review of medical physiology, 19th edn. Appleton & Lange, Stamford

Shen Y, Goerner FL, Snyder C, Morelli JN, Hao D, Hu D, Li X, Runge VM (2015) T1 relaxivities of gadolinium-based magnetic resonance contrast agents in human whole blood at 1.5, 3, and 7 T. Invest Radiol 50(5):330–338CrossRefPubMed

Liu P, Chalak LF, Krishnamurthy LC, Mir I, Peng SL, Huang H, Lu H (2016) T1 and T2 values of human neonatal blood at 3 Tesla: dependence on hematocrit, oxygenation, and temperature. Magn Reson Med 75(4):1730–1735CrossRefPubMed

Zhang X, Petersen ET, Ghariq E, De Vis JB, Webb AG, Teeuwisse WM, Hendrikse J, van Osch MJ (2013) In vivo blood T(1) measurements at 1.5 T, 3 T, and 7 T. Magn Reson Med 70(4):1082–1086CrossRefPubMed

Piechnik SK, Ferreira VM, Lewandowski AJ, Ntusi NA, Banerjee R, Holloway C, Hofman MB, Sado DM, Maestrini V, White SK, Lazdam M, Karamitsos T, Moon JC, Neubauer S, Leeson P, Robson MD (2013) Normal variation of magnetic resonance T1 relaxation times in the human population at 1.5 T using ShMOLLI. J Cardiovasc Magn Reson 15(13):11

Varela M, Hajnal JV, Petersen ET, Golay X, Merchant N, Larkman DJ (2011) A method for rapid in vivo measurement of blood T1. NMR Biomed 24(1):80–88CrossRefPubMed

Treibel TA, Nasis A, Fontana M, Maestrini V, Castelletti S, Bhuva AN, Rosmini S, Abdel-Gadir A, Bulluck H, Kellman P, Piechnik SK, Robson MD, Moon J (2015) An instantaneous ECV with no blood sampling: using native blood T1 for hematocrit is as good as standard ECV. J Cardiovasc Magn Reson 17(1):Q129CrossRefPubMedCentral

Look DC, Locker DR (1970) Time saving in measurement of NMR end EPR relaxation times. Rev Sci Instrum 41:250–251CrossRef

Messroghli DR, Radjenovic A, Kozerke S, Higgins DM, Sivananthan MU, Ridgway JP (2004) Modified Look-Locker inversion recovery (MOLLI) for high-resolution T ₁ mapping of the heart. Magn Reson Med 52(1):141–146CrossRefPubMed

10.

Qin Q, Strouse JJ, van Zijl PC (2011) Fast measurement of blood T ₁ in the human jugular vein at 3 Tesla. Magn Reson Med 65(5):1297–1304CrossRefPubMed

11.

Li W, Liu P, Lu H, Strouse JJ, van Zijl PC, Qin Q (2016) Fast measurement of blood T ₁ in the human carotid artery at 3T: accuracy, precision, and reproducibility. Magn Reson Med 77(6):7

12.

Vassiliou V, Heng EL, Nyktari E, Greiser A, Firmin D, Pennell DJ, Gatehouse P, Prasad SK (2015) Effect of temperature and heart rate variability on Phantom T1 maps. J Cardiovasc Magn Reson 17(1):W24CrossRefPubMedCentral

13.

Scheffler K, Lehnhardt S (2003) Principles and applications of balanced SSFP techniques. Eur Radiol 13(11):2409–2418CrossRefPubMed

14.

Deichmann RH, Haase A (1992) Quantification of T1 Values by SNAPSHOT-FLASH NMR Imaging. J Magn Reson 96(3):608–612

15.

Taylor AJ, Salerno M, Dharmakumar R, Jerosch-Herold M (2016) T1 mapping: basic techniques and clinical applications. JACC Cardiovasc Imaging 9(1):67–81CrossRefPubMed

16.

Kellman P, Hansen MS (2014) T1-mapping in the heart: accuracy and precision. J Cardiovasc Magn Reson 16(1):2CrossRefPubMedPubMedCentral

17.

Kalavagunta C, Michaeli S, Metzger GJ (2014) In-vitro Gd-DTPA relaxometry studies in oxygenated venous human blood and aqueous solution at 3 and 7T. Contrast Media Mol Imaging 9(2):169–176CrossRefPubMedPubMedCentral

18.

Shimada K, Nagasaka T, Shidahara M, Machida Y, Tamura H (2012) In vivo measurement of longitudinal relaxation time of human blood by inversion-recovery fast gradient-echo MR imaging at 3T. Magn Reson Med Sci 11(4):265–271CrossRefPubMed

19.

Wu W-C, Jain V, Li C, Giannetta M, Hurt H, Wehrli FW, Wang DJJ (2010) In vivo venous blood T(1) measurement using inversion recovery true-FISP in children and adults. Magn Reson Med 64(4):1140–1147CrossRefPubMedPubMedCentral

20.

Zhang X, Petersen ET, Ghariq E, Vis JB, Webb AG, Teeuwisse WM, Hendrikse J, Osch MJP (2013) In vivo blood T1 measurements at 1.5 T, 3 T, and 7 T. Magn Reson Med 70(4):1082–1086CrossRefPubMed

21.

McRobbie DW (2007) MRI from picture to proton, 2nd edn. Cambridge University Press, Cambridge

22.

Gallix BP, Taourel P, Dauzat M, Bruel JM, Lafortune M (1997) Flow pulsatility in the portal venous system: a study of Doppler sonography in healthy adults. Am J Roentgenol 169(1):141–144CrossRef

Title: Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters
Authors: Svein Are Sirirud Vatnehol
Per Kristian Hol
Atle Bjørnerud
Mahmood Amiry-Moghaddam
Camilla Haglerød
Tryggve Holck Storås
Publication date: 01-06-2019
Publisher: Springer International Publishing
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 3/2019
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI: https://doi.org/10.1007/s10334-018-00731-1

At a glance: The STEP trials

Springer Medicine

Precision of T1-relaxation time measurements in the hepatic portal vein: influence of measurement technique and sequence parameters

Abstract

Objective

Materials and methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusion

Please log in to get access to this content

Other articles of this Issue 3/2019

A study of within-subject reliability of the brain’s default-mode network

Projection-based respiratory-resolved left ventricular volume measurements in patients using free-breathing double golden-angle 3D radial acquisition

Challenges for labeling and longitudinal tracking of adoptively transferred autoreactive T lymphocytes in an experimental type-1 diabetes model

A phase-cycled temperature-sensitive fast spin echo sequence with conductivity bias correction for monitoring of mild RF hyperthermia with PRFS

Feasibility of diffusion-weighted imaging with DWIBS in staging Hodgkin lymphoma in pediatric patients: comparison with PET/CT

Accelerated multi-contrast high isotropic resolution 3D intracranial vessel wall MRI using a tailored k-space undersampling and partially parallel reconstruction strategy