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Journal of Assisted Reproduction and Genetics

Published in:

01-09-2019 | Pre-Eclampsia | Assisted Reproduction Technologies

Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study

Authors: Anna M. Modest, Katherine M. Johnson, S. Ananth Karumanchi, Nina Resetkova, Brett C. Young, Matthew P. Fox, Lauren A. Wise, Michele R. Hacker

Published in: Journal of Assisted Reproduction and Genetics | Issue 9/2019

Abstract

Purpose

Assess the risk of ischemic placental disease (IPD) among in vitro fertilization (IVF; donor and autologous) pregnancies compared with non-IVF pregnancies.

Methods

This was a retrospective cohort study of deliveries from 2000 to 2015 at a tertiary hospital. The exposures, donor, and autologous IVF, were compared with non-IVF pregnancies and donor IVF pregnancies were also compared with autologous IVF pregnancies. The outcome was IPD (preeclampsia, placental abruption, small for gestational age (SGA), or intrauterine fetal demise due to placental insufficiency). We defined SGA as birthweight < 10th percentiles for gestational age and sex. A secondary analysis restricted SGA to < 3rd percentile.

Results

Of 69,084 deliveries in this cohort, 262 resulted from donor IVF and 3,501 from autologous IVF. Compared with non-IVF pregnancies, IPD was more common among donor IVF pregnancies (risk ratio (RR) = 2.9; 95% CI 2.5–3.4) and autologous IVF pregnancies (RR = 2.0; 95% CI 1.9–2.1), adjusted for age and parity. IVF pregnancies were more likely to be complicated by preeclampsia (donor RR = 3.8; 95% CI 2.8–5.0 and autologous RR = 2.2; 95% CI 2.0–2.5, adjusted for age, parity, and marital status), placental abruption (donor RR = 3.8; 95% CI 2.1–6.7 and autologous RR = 2.5; 95% CI 2.1–3.1, adjusted for age), and SGA (donor RR = 2.7; 95% CI 2.1–3.4 and autologous RR = 2.0; 95% CI 1.9–2.2, adjusted for age and parity). Results were similar when restricting SGA to < 3rd percentile.

Conclusion

Pregnancies conceived using donor IVF and autologous IVF were at higher risk of IPD and its associated conditions than non-IVF pregnancies and associations were consistently stronger for donor IVF pregnancies.

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Title: Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study
Authors: Anna M. Modest
Katherine M. Johnson
S. Ananth Karumanchi
Nina Resetkova
Brett C. Young
Matthew P. Fox
Lauren A. Wise
Michele R. Hacker
Publication date: 01-09-2019
Publisher: Springer US
Keyword: Pre-Eclampsia
Published in: Journal of Assisted Reproduction and Genetics / Issue 9/2019
Print ISSN: 1058-0468
Electronic ISSN: 1573-7330
DOI: https://doi.org/10.1007/s10815-019-01545-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk of ischemic placental disease is increased following in vitro fertilization with oocyte donation: a retrospective cohort study

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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