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Neuroradiology

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01-09-2013 | Invited Review

Potential mechanisms of cerebellar hypoplasia in prematurity

Author: Emily W. Y. Tam

Published in: Neuroradiology | Special Issue 2/2013

Abstract

Introduction

The cerebellum undergoes dramatic growth and maturation over the neonatal period after preterm birth and is thus particularly sensitive to impaired development due to various clinical factors.

Methods

Impairments in growth can occur independent of cerebellar parenchymal damage, such as from local hemorrhage, resulting from reduced expression of sonic hedgehog signaling to trigger the appropriate expansion of the granule precursor cells.

Results

The primary risk factors for impaired cerebellar development include postnatal glucocorticoid exposure, which has direct effects on the sonic hedgehog pathway, and supratentorial brain injury, including intraventricular hemorrhage and white matter injury, which may result in crossed cerebellar diaschisis and local toxic effects of blood products on the external granular layer. Other cardiorespiratory and nutritional factors may also exist. Impaired cerebellar development is associated with adverse outcomes in motor and cognitive development.

Conclusion

New approaches to care to counteract these risk factors may help improve long-term outcome after preterm birth.

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Title: Potential mechanisms of cerebellar hypoplasia in prematurity
Author: Emily W. Y. Tam
Publication date: 01-09-2013
Publisher: Springer Berlin Heidelberg
Published in: Neuroradiology / Issue Special Issue 2/2013
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-013-1230-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Potential mechanisms of cerebellar hypoplasia in prematurity

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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