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Pediatric Radiology
Published in: Pediatric Radiology 8/2011

01-08-2011 | Original Article

Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children

Authors: Annika Lind, Riitta Parkkola, Liisa Lehtonen, Petriina Munck, Jonna Maunu, Helena Lapinleimu, Leena Haataja, PIPARI Study Group

Published in: Pediatric Radiology | Issue 8/2011

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Abstract

Background

Altered brain volumes and associations between volumes and developmental outcomes have been reported in prematurely born children.

Objectives

To assess which regional brain volumes are different in very low birth weight (VLBW) children without neurodevelopmental impairments ([NDI] cerebral palsy, hearing loss, blindness and significantly delayed cognitive performance) compared with VLBW children with NDI, and to evaluate the association between regional brain volumes at term-equivalent age and cognitive development and neurological performance at a corrected age of 2 years.

Materials and methods

The study group consisted of a regional cohort of 164 VLBW children, divided into one group of children without NDI (n = 148) and one group of children with NDI (n = 16). Brain (MRI) was performed at term-equivalent age, from which brain volumes were manually analysed. Cognitive development was assessed with the Bayley Scales of Infant Development II (BSID-II), and neurological performance with the Hammersmith Infant Neurological Examination at the corrected age of 2 years.

Results

The volumes of total brain tissue, cerebrum, frontal lobes, basal ganglia and thalami, and cerebellum were significantly smaller, and the volume of the ventricles significantly larger, in the children with NDI than in those without NDI. Even in children without NDI, a smaller cerebellar volume was significantly correlated with poor neurological performance at 2 years of corrected age.

Conclusion

Volumetric analysis at brain MRI can provide an additional parameter for early prediction of outcome in VLBW children.
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Metadata
Title
Associations between regional brain volumes at term-equivalent age and development at 2 years of age in preterm children
Authors
Annika Lind
Riitta Parkkola
Liisa Lehtonen
Petriina Munck
Jonna Maunu
Helena Lapinleimu
Leena Haataja
PIPARI Study Group
Publication date
01-08-2011
Publisher
Springer-Verlag
Published in
Pediatric Radiology / Issue 8/2011
Print ISSN: 0301-0449
Electronic ISSN: 1432-1998
DOI
https://doi.org/10.1007/s00247-011-2071-x

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