Skip to main content
Top
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Research

Postoperative pain of single-visit endodontic treatment with gutta-percha versus MTA filling: a randomized superiority trial

Authors: Masoud Khabiri, Sahel Kamgar, Pedram Iranmanesh, Abbasali Khademi, Mahmoud Torabinejad

Published in: BMC Oral Health | Issue 1/2023

Login to get access

Abstract

Background

Postoperative pain has remained a challenge for clinicians. This randomized superiority trial compared the levels of postoperative pain following the use of gutta-percha (GP) and sealer or mineral trioxide aggregate (MTA) as root canal filling materials in teeth with asymptomatic apical periodontitis.

Methods

A total of 119 patients were initially evaluated in this two-arm, parallel-group, single-blind, superiority randomized trial. The inclusion criteria were participants aged 18–65 years with single-canal premolars diagnosed with asymptomatic apical periodontitis. The participants were finally divided into two groups using the permuted block randomization method. In the GP group (N = 46), the cleaned and shaped root canals were filled with gutta-percha and AH Plus sealer, while in the MTA group (N = 48), the cleaned and shaped root canals were filled with an MTA apical filling and a coronal gutta-percha and sealer. Patient pain level was measured 6, 12, 24, 48, and 72 h postoperatively using a 10-point visual analog scale (VAS). The data were analyzed by the chi-square, independent t, Friedman, and Mann-Whitney U tests.

Results

The mean of VAS scores decreased significantly over time in both groups (P < 0.001). The mean VAS scores were significantly lower in the MTA filling group than in the other group (P < 0.05). Female patients reported higher VAS scores at 6- and 12-hour periods in both groups (P < 0.05).

Conclusion

MTA as a root canal filling material might be a valuable option for clinicians due to its low postoperative pain.

Trial registration

The trial protocol was registered at the Registry of Clinical Trials (IRCT20191104045331N1).
Appendix
Available only for authorised users
Literature
1.
go back to reference Marshall JG. Consideration of steroids for endodontic pain. Endod Top. 2002;3:41–51.CrossRef Marshall JG. Consideration of steroids for endodontic pain. Endod Top. 2002;3:41–51.CrossRef
2.
go back to reference Sathorn C, Parashos P, Messer H. The prevalence of postoperative pain and flare-up in single- and multiple-visit endodontic treatment: a systematic review. Int Endod J. 2008;41:91–9.PubMedCrossRef Sathorn C, Parashos P, Messer H. The prevalence of postoperative pain and flare-up in single- and multiple-visit endodontic treatment: a systematic review. Int Endod J. 2008;41:91–9.PubMedCrossRef
4.
go back to reference Abbasipour F, Bakhtiar H, Vatanpour M, Khalilkhani H, Torabzadeh H, Janahmadi M. A comparative study on anti-hyperalgesia effect of MTA and Ketoprofen in inflammatory pain. Iran Endod J. 2009;4:81–6.PubMedPubMedCentral Abbasipour F, Bakhtiar H, Vatanpour M, Khalilkhani H, Torabzadeh H, Janahmadi M. A comparative study on anti-hyperalgesia effect of MTA and Ketoprofen in inflammatory pain. Iran Endod J. 2009;4:81–6.PubMedPubMedCentral
6.
go back to reference ØRstavik D. Materials used for root canal obturation: technical, biological and clinical testing. Endod Top. 2005;12:25–38.CrossRef ØRstavik D. Materials used for root canal obturation: technical, biological and clinical testing. Endod Top. 2005;12:25–38.CrossRef
8.
go back to reference Patil P, Banga KS, Pawar AM, Pimple S, Ganeshan R. Influence of root canal obturation using gutta-percha with three different sealers on root reinforcement of endodontically treated teeth. An in vitro comparative study of mandibular incisors. J Conserv Dent. 2017;20:241–4.PubMedPubMedCentralCrossRef Patil P, Banga KS, Pawar AM, Pimple S, Ganeshan R. Influence of root canal obturation using gutta-percha with three different sealers on root reinforcement of endodontically treated teeth. An in vitro comparative study of mandibular incisors. J Conserv Dent. 2017;20:241–4.PubMedPubMedCentralCrossRef
9.
go back to reference Barletta FB, Rahde NDM, Limongi O, Moura AAM, Zanesco C, Mazocatto G. In vitro comparative analysis of 2 mechanical techniques for removing gutta-percha during retreatment. J Can Dent Assoc (Tor). 2007;73:65. Barletta FB, Rahde NDM, Limongi O, Moura AAM, Zanesco C, Mazocatto G. In vitro comparative analysis of 2 mechanical techniques for removing gutta-percha during retreatment. J Can Dent Assoc (Tor). 2007;73:65.
10.
go back to reference Kaur A, Shah N, Logani A, Mishra N. Biotoxicity of commonly used root canal sealers: a meta-analysis. J Conservative Dentistry. 2015;18:83–8.CrossRef Kaur A, Shah N, Logani A, Mishra N. Biotoxicity of commonly used root canal sealers: a meta-analysis. J Conservative Dentistry. 2015;18:83–8.CrossRef
11.
go back to reference Surya Raghavendra S, Jadhav GR, Gathani KM, Kotadia P. Bioceramics in endodontics – a review. J Istanbul Univ Fac Dent. 2017;51(3 Suppl 1):128–S137. Surya Raghavendra S, Jadhav GR, Gathani KM, Kotadia P. Bioceramics in endodontics – a review. J Istanbul Univ Fac Dent. 2017;51(3 Suppl 1):128–S137.
12.
go back to reference Storm B, Eichmiller FC, Tordik PA, Goodell GG. Setting expansion of Gray and White Mineral Trioxide Aggregate and Portland Cement. J Endod. 2008;34:80–2.PubMedCrossRef Storm B, Eichmiller FC, Tordik PA, Goodell GG. Setting expansion of Gray and White Mineral Trioxide Aggregate and Portland Cement. J Endod. 2008;34:80–2.PubMedCrossRef
13.
go back to reference Jitaru S, Hodisan I, Timis L, Lucian A, Bud M. The use of bioceramics in endodontics - literature review. Clujul Med. 2016;89:470–3.PubMedPubMedCentral Jitaru S, Hodisan I, Timis L, Lucian A, Bud M. The use of bioceramics in endodontics - literature review. Clujul Med. 2016;89:470–3.PubMedPubMedCentral
14.
15.
go back to reference Alsulaimani RS. Single-visit endodontic treatment of mature teeth with chronic apical abscesses using mineral trioxide aggregate cement: a randomized clinical trial. BMC Oral Health. 2016;16:1–10.CrossRef Alsulaimani RS. Single-visit endodontic treatment of mature teeth with chronic apical abscesses using mineral trioxide aggregate cement: a randomized clinical trial. BMC Oral Health. 2016;16:1–10.CrossRef
16.
go back to reference Terauchi Y, Torabinejad M, Wong K, Bogen G. The Effect of Mineral Trioxide Aggregate Obturation levels on the Outcome of Endodontic Retreatment: an observational study. J Endod. 2023;49:664–74.PubMedCrossRef Terauchi Y, Torabinejad M, Wong K, Bogen G. The Effect of Mineral Trioxide Aggregate Obturation levels on the Outcome of Endodontic Retreatment: an observational study. J Endod. 2023;49:664–74.PubMedCrossRef
17.
go back to reference Bogen G, Kuttler S. Mineral Trioxide Aggregate Obturation: A Review and Case Series. J Endod. 2009;35:777–90.PubMedCrossRef Bogen G, Kuttler S. Mineral Trioxide Aggregate Obturation: A Review and Case Series. J Endod. 2009;35:777–90.PubMedCrossRef
18.
go back to reference Paul M, Mazumdar D, Vyavahare N, Baranwal A. Healing of the periapical lesion in posterior teeth with mineral trioxide aggregate using orthograde technique - two case reports. Contemp Clin Dent. 2012;3:264.CrossRef Paul M, Mazumdar D, Vyavahare N, Baranwal A. Healing of the periapical lesion in posterior teeth with mineral trioxide aggregate using orthograde technique - two case reports. Contemp Clin Dent. 2012;3:264.CrossRef
19.
20.
go back to reference Torabinejad M, Parirokh M, Dummer PMH. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complications. Int Endod J. 2018;51:284–317.PubMedCrossRef Torabinejad M, Parirokh M, Dummer PMH. Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview - part II: other clinical applications and complications. Int Endod J. 2018;51:284–317.PubMedCrossRef
21.
go back to reference Abbasipour F, Akheshteh V, Rastqar A, Khalilkhani H, Asgary S, Janahmadi M. Comparing the effects of mineral trioxide aggregate and calcium enriched mixture on neuronal cells using an electrophysiological approach. Iran Endod J. 2012;7:79–87.PubMedPubMedCentral Abbasipour F, Akheshteh V, Rastqar A, Khalilkhani H, Asgary S, Janahmadi M. Comparing the effects of mineral trioxide aggregate and calcium enriched mixture on neuronal cells using an electrophysiological approach. Iran Endod J. 2012;7:79–87.PubMedPubMedCentral
22.
go back to reference Ruparel NB, Ruparel SB, Chen PB, Ishikawa B, Diogenes A. Direct effect of endodontic sealers on trigeminal neuronal activity. J Endod. 2014;40:683–7.PubMedCrossRef Ruparel NB, Ruparel SB, Chen PB, Ishikawa B, Diogenes A. Direct effect of endodontic sealers on trigeminal neuronal activity. J Endod. 2014;40:683–7.PubMedCrossRef
23.
go back to reference Mostafa MEHAA, El-Shrief YAI, Anous WIO, Hassan MW, Salamah FTA, El Boghdadi RM, et al. Postoperative pain following endodontic irrigation using 1.3% versus 5.25% sodium hypochlorite in mandibular molars with necrotic pulps: a randomized double-blind clinical trial. Int Endod J. 2020;53:154–66.PubMedCrossRef Mostafa MEHAA, El-Shrief YAI, Anous WIO, Hassan MW, Salamah FTA, El Boghdadi RM, et al. Postoperative pain following endodontic irrigation using 1.3% versus 5.25% sodium hypochlorite in mandibular molars with necrotic pulps: a randomized double-blind clinical trial. Int Endod J. 2020;53:154–66.PubMedCrossRef
24.
go back to reference Van Der Sluis LWM, Gambarini G, Wu MK, Wesselink PR. The influence of volume, type of irrigant and flushing method on removing artificially placed dentine debris from the apical root canal during passive ultrasonic irrigation. Int Endod J. 2006;39:472–6.PubMedCrossRef Van Der Sluis LWM, Gambarini G, Wu MK, Wesselink PR. The influence of volume, type of irrigant and flushing method on removing artificially placed dentine debris from the apical root canal during passive ultrasonic irrigation. Int Endod J. 2006;39:472–6.PubMedCrossRef
25.
go back to reference Mehrvarzfar P, Abbott PV, Saghiri MA, Delvarani A, Asgar K, Lotfi M, et al. Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial. Int Endod J. 2012;45:76–82.PubMedCrossRef Mehrvarzfar P, Abbott PV, Saghiri MA, Delvarani A, Asgar K, Lotfi M, et al. Effects of three oral analgesics on postoperative pain following root canal preparation: a controlled clinical trial. Int Endod J. 2012;45:76–82.PubMedCrossRef
26.
go back to reference Mattscheck DJ, Law AS, Noblett WC. Retreatment versus initial root canal treatment: factors affecting posttreatment pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:321–4.PubMedCrossRef Mattscheck DJ, Law AS, Noblett WC. Retreatment versus initial root canal treatment: factors affecting posttreatment pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;92:321–4.PubMedCrossRef
27.
go back to reference Nagendrababu V, Gutmann JL. Factors associated with postobturation pain following single-visit nonsurgical root canal treatment: a systematic review. Quintessence Int. 2017;48:193–208.PubMed Nagendrababu V, Gutmann JL. Factors associated with postobturation pain following single-visit nonsurgical root canal treatment: a systematic review. Quintessence Int. 2017;48:193–208.PubMed
28.
go back to reference Pak JG, White SN. Pain prevalence and severity before, during, and after root canal treatment: a systematic review. J Endod. 2011;37:429–38.PubMedCrossRef Pak JG, White SN. Pain prevalence and severity before, during, and after root canal treatment: a systematic review. J Endod. 2011;37:429–38.PubMedCrossRef
29.
go back to reference Nagendrababu V, Pulikkotil SJ, Jinatongthai P, Veettil SK, Teerawattanapong N, Gutmann JL. Efficacy and safety of oral Premedication on Pain after Nonsurgical Root Canal treatment: a systematic review and network Meta-analysis of Randomized controlled trials. J Endod. 2019;45:364–71.PubMedCrossRef Nagendrababu V, Pulikkotil SJ, Jinatongthai P, Veettil SK, Teerawattanapong N, Gutmann JL. Efficacy and safety of oral Premedication on Pain after Nonsurgical Root Canal treatment: a systematic review and network Meta-analysis of Randomized controlled trials. J Endod. 2019;45:364–71.PubMedCrossRef
30.
go back to reference Ehrmann EH, Messer HH, Adams GG. The relationship of intracanal medicaments to postoperative pain in endodontics. Int Endod J. 2003;36:868–75.PubMedCrossRef Ehrmann EH, Messer HH, Adams GG. The relationship of intracanal medicaments to postoperative pain in endodontics. Int Endod J. 2003;36:868–75.PubMedCrossRef
31.
go back to reference Dawood AE, Parashos P, Wong RHK, Reynolds EC, Manton DJ. Calcium silicate-based cements: composition, properties, and clinical applications. J Investig Clin Dent. 2017;8:e12195.CrossRef Dawood AE, Parashos P, Wong RHK, Reynolds EC, Manton DJ. Calcium silicate-based cements: composition, properties, and clinical applications. J Investig Clin Dent. 2017;8:e12195.CrossRef
32.
go back to reference Reyes-Carmona JF, Santos ARS, Figueiredo CP, Felippe MS, Felippe WT, Cordeiro MM. In vivo host interactions with mineral trioxide aggregate and calcium hydroxide: inflammatory molecular signaling assessment. J Endod. 2011;37:1225–35.PubMedCrossRef Reyes-Carmona JF, Santos ARS, Figueiredo CP, Felippe MS, Felippe WT, Cordeiro MM. In vivo host interactions with mineral trioxide aggregate and calcium hydroxide: inflammatory molecular signaling assessment. J Endod. 2011;37:1225–35.PubMedCrossRef
33.
go back to reference Staffoli S, Plotino G, Torrijos BGN, Grande NM, Bossù M, Gambarini G, et al. Regenerative endodontic procedures using contemporary endodontic materials. Mater (Basel). 2019;16:908.CrossRef Staffoli S, Plotino G, Torrijos BGN, Grande NM, Bossù M, Gambarini G, et al. Regenerative endodontic procedures using contemporary endodontic materials. Mater (Basel). 2019;16:908.CrossRef
34.
go back to reference Prati C, Gandolfi MG. Calcium silicate bioactive cements: biological perspectives and clinical applications. Dent Mater. 2015;31:351–70.PubMedCrossRef Prati C, Gandolfi MG. Calcium silicate bioactive cements: biological perspectives and clinical applications. Dent Mater. 2015;31:351–70.PubMedCrossRef
35.
go back to reference Graunaite I, Skucaite N, Lodiene G, Agentiene I, Machiulskiene V. Effect of Resin-based and Bioceramic Root Canal Sealers on Postoperative Pain: a Split-mouth randomized controlled trial. J Endod. 2018;44:689–93.PubMedCrossRef Graunaite I, Skucaite N, Lodiene G, Agentiene I, Machiulskiene V. Effect of Resin-based and Bioceramic Root Canal Sealers on Postoperative Pain: a Split-mouth randomized controlled trial. J Endod. 2018;44:689–93.PubMedCrossRef
36.
go back to reference Zhang W, Peng B. Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH Plus. Dent Mater J. 2015;34:774–80.PubMedCrossRef Zhang W, Peng B. Tissue reactions after subcutaneous and intraosseous implantation of iRoot SP, MTA and AH Plus. Dent Mater J. 2015;34:774–80.PubMedCrossRef
37.
go back to reference Ruparel NB, Teixeira FB, Ferraz CCR, Diogenes A. Direct effect of intracanal medicaments on survival of stem cells of the apical papilla. J Endod. 2012;38:1372–5.PubMedCrossRef Ruparel NB, Teixeira FB, Ferraz CCR, Diogenes A. Direct effect of intracanal medicaments on survival of stem cells of the apical papilla. J Endod. 2012;38:1372–5.PubMedCrossRef
38.
go back to reference Atav Ates A, Dumani A, Yoldas O, Unal I. Post-obturation pain following the use of carrier-based system with AH Plus or iRoot SP sealers: a randomized controlled clinical trial. Clin Oral Investig. 2019;23:3053–61.PubMedCrossRef Atav Ates A, Dumani A, Yoldas O, Unal I. Post-obturation pain following the use of carrier-based system with AH Plus or iRoot SP sealers: a randomized controlled clinical trial. Clin Oral Investig. 2019;23:3053–61.PubMedCrossRef
39.
go back to reference Nabi S, Farooq R, Purra A, Ahmed F. Comparison of various sealers on postoperative pain in single-visit endodontics: a randomized clinical study. Indian J Dent Sci. 2019;11:99.CrossRef Nabi S, Farooq R, Purra A, Ahmed F. Comparison of various sealers on postoperative pain in single-visit endodontics: a randomized clinical study. Indian J Dent Sci. 2019;11:99.CrossRef
40.
go back to reference Alí A, Olivieri JG, Duran-Sindreu F, Abella F, Roig M, García-Font M. Influence of preoperative pain intensity on postoperative pain after root canal treatment: a prospective clinical study. J Dent. 2016;45:39–42.PubMedCrossRef Alí A, Olivieri JG, Duran-Sindreu F, Abella F, Roig M, García-Font M. Influence of preoperative pain intensity on postoperative pain after root canal treatment: a prospective clinical study. J Dent. 2016;45:39–42.PubMedCrossRef
41.
go back to reference Shoaib B, Farraj S, Al, Alenazi R, Hussain A, Therapy NA-. Prevalence of Pain after receiving Root Canal treatment: a cross-sectional study. J Appl Dent Med Sci. 2019;6:7. Shoaib B, Farraj S, Al, Alenazi R, Hussain A, Therapy NA-. Prevalence of Pain after receiving Root Canal treatment: a cross-sectional study. J Appl Dent Med Sci. 2019;6:7.
42.
go back to reference Ng YL, Glennon JP, Setchell DJ, Gulabivala K. Prevalence of and factors affecting post-obturation pain in patients undergoing root canal treatment. Int Endod J. 2004;37:381–91.PubMedCrossRef Ng YL, Glennon JP, Setchell DJ, Gulabivala K. Prevalence of and factors affecting post-obturation pain in patients undergoing root canal treatment. Int Endod J. 2004;37:381–91.PubMedCrossRef
43.
go back to reference Azim AA, Azim KA, Abbott PV. Prevalence of inter-appointment endodontic flare-ups and host-related factors. Clin Oral Investig. 2017;21:889–94.PubMedCrossRef Azim AA, Azim KA, Abbott PV. Prevalence of inter-appointment endodontic flare-ups and host-related factors. Clin Oral Investig. 2017;21:889–94.PubMedCrossRef
44.
go back to reference Polycarpou N, Ng YL, Canavan D, Moles DR, Gulabivala K. Prevalence of persistent pain after endodontic treatment and factors affecting its occurrence in cases with complete radiographic healing. Int Endod J. 2005;38:169–78.PubMedCrossRef Polycarpou N, Ng YL, Canavan D, Moles DR, Gulabivala K. Prevalence of persistent pain after endodontic treatment and factors affecting its occurrence in cases with complete radiographic healing. Int Endod J. 2005;38:169–78.PubMedCrossRef
45.
go back to reference Jespersen JJ, Hellstein J, Williamson A, Johnson WT, Qian F. Evaluation of Dental Pulp sensibility tests in a clinical setting. J Endod. 2014;40:351–4.PubMedCrossRef Jespersen JJ, Hellstein J, Williamson A, Johnson WT, Qian F. Evaluation of Dental Pulp sensibility tests in a clinical setting. J Endod. 2014;40:351–4.PubMedCrossRef
46.
go back to reference O’Sullivan SM, Hartwell GR. Obturation of a retained primary mandibular second molar using mineral trioxide aggregate: a case report. J Endod. 2001;27:703–5.PubMedCrossRef O’Sullivan SM, Hartwell GR. Obturation of a retained primary mandibular second molar using mineral trioxide aggregate: a case report. J Endod. 2001;27:703–5.PubMedCrossRef
47.
go back to reference Ramos JC, Palma PJ, Nascimento R, Caramelo F, Messias A, Vinagre A, et al. 1-year in Vitro evaluation of tooth Discoloration Induced by 2 calcium silicate–based cements. J Endod. 2016;42:1403–7.PubMedCrossRef Ramos JC, Palma PJ, Nascimento R, Caramelo F, Messias A, Vinagre A, et al. 1-year in Vitro evaluation of tooth Discoloration Induced by 2 calcium silicate–based cements. J Endod. 2016;42:1403–7.PubMedCrossRef
48.
go back to reference Palma PJ, Marques JA, Falacho RI, Correia E, Vinagre A, Santos JM et al. Six-Month Color Stability Assessment of Two Calcium Silicate-Based Cements Used in Regenerative Endodontic Procedures. J Funct Biomater 2019, Vol 10, Page 14. 2019;10:14. Palma PJ, Marques JA, Falacho RI, Correia E, Vinagre A, Santos JM et al. Six-Month Color Stability Assessment of Two Calcium Silicate-Based Cements Used in Regenerative Endodontic Procedures. J Funct Biomater 2019, Vol 10, Page 14. 2019;10:14.
49.
go back to reference Palma PJ, Marques JA, Santos J, Falacho RI, Sequeira D, Diogo P, et al. Tooth discoloration after regenerative endodontic procedures with Calcium Silicate-Based Cements—An Ex vivo study. Appl Sci 2020. 2020;10:10:5793. Palma PJ, Marques JA, Santos J, Falacho RI, Sequeira D, Diogo P, et al. Tooth discoloration after regenerative endodontic procedures with Calcium Silicate-Based Cements—An Ex vivo study. Appl Sci 2020. 2020;10:10:5793.
50.
go back to reference Paulo CR, Marques JA, Sequeira DB, Diogo P, Paiva R, Palma PJ et al. Influence of blood contamination on push-out bond strength of three calcium silicate-based materials to root dentin. Appl Sci. 2021;11. Paulo CR, Marques JA, Sequeira DB, Diogo P, Paiva R, Palma PJ et al. Influence of blood contamination on push-out bond strength of three calcium silicate-based materials to root dentin. Appl Sci. 2021;11.
51.
go back to reference Palma PJ, Marques JA, Antunes M, Falacho RI, Sequeira D, Roseiro L, et al. Effect of restorative timing on shear bond strength of composite resin/calcium silicate–based cements adhesive interfaces. Clin Oral Investig. 2021;25:3131–9.PubMedCrossRef Palma PJ, Marques JA, Antunes M, Falacho RI, Sequeira D, Roseiro L, et al. Effect of restorative timing on shear bond strength of composite resin/calcium silicate–based cements adhesive interfaces. Clin Oral Investig. 2021;25:3131–9.PubMedCrossRef
52.
go back to reference Xavier MT, Costa AL, Caramelo FJ, Palma PJ, Ramos JC. Evaluation of the interfaces between restorative and regenerative biomaterials used in vital pulp therapy. Mater (Basel). 2021;14. Xavier MT, Costa AL, Caramelo FJ, Palma PJ, Ramos JC. Evaluation of the interfaces between restorative and regenerative biomaterials used in vital pulp therapy. Mater (Basel). 2021;14.
Metadata
Title
Postoperative pain of single-visit endodontic treatment with gutta-percha versus MTA filling: a randomized superiority trial
Authors
Masoud Khabiri
Sahel Kamgar
Pedram Iranmanesh
Abbasali Khademi
Mahmoud Torabinejad
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03372-6

Other articles of this Issue 1/2023

BMC Oral Health 1/2023 Go to the issue