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Annals of Nuclear Medicine
Published in: Annals of Nuclear Medicine 5/2024

12-02-2024 | Positron Emission Tomography | Original Article

Radiolabeled florescent-magnetic graphene oxide nanosheets: probing the biodistribution of a potential PET-MRI hybrid imaging agent for detection of fibrosarcoma tumor

Authors: Ahad Amiri, Yousef Fazaeli, Hakimeh Zare, Mohammad Eslami-Kalantari, Shahzad Feizi, Zahra Shahedi, Mohammadreza Afrasyabi

Published in: Annals of Nuclear Medicine | Issue 5/2024

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Abstract

Purpose

Radiolabeled graphene oxide (GO) nanosheets has been one of the most extensively studied nanoplatform for in vivo radioisotope delivery. Herein, we describe the functionalization of the surface of GO nanosheets with Fe3O4 magnetic nanoparticles, cysteine amino acid as an interface ligand, and cadmium telluride quantum dots.

Materials and Methods

To enable In vivo PET imaging, the GO@Fe3O4-cys-CdTe QDs were labeled with 68Ga to yield [68Ga] Ga-Go@ Fe3O4-Cys-CdTe QDs. Furthermore, serum stability tests were performed and the biological behavior of the nanocomposite was evaluated in rats bearing fibrosarcoma tumor.

Results

Liver, blood and tumor were the most accumulated sites at 1 h after the injection, and the radiolabeled nanocomposite as a PET/MRI imaging agent showed fast depletion from body and acceptable tumor uptake.

Conclusion

Magnetic (Fe3O4) and fluorescent components (CdTe QDs) along with a positron-emitting radionuclide will help to design a multimodal imaging system (PET/MRI/OI) which will offer the advantages of combined imaging techniques and further possible used in localized radionuclide therapy. Overall, [68Ga] Ga-GO@Fe3O4-cys-CdTe QDs nanocomposite shows great promise as a radiolabeled imaging agent owing to high accumulation in tumor region.
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Metadata
Title
Radiolabeled florescent-magnetic graphene oxide nanosheets: probing the biodistribution of a potential PET-MRI hybrid imaging agent for detection of fibrosarcoma tumor
Authors
Ahad Amiri
Yousef Fazaeli
Hakimeh Zare
Mohammad Eslami-Kalantari
Shahzad Feizi
Zahra Shahedi
Mohammadreza Afrasyabi
Publication date
12-02-2024
Publisher
Springer Nature Singapore
Published in
Annals of Nuclear Medicine / Issue 5/2024
Print ISSN: 0914-7187
Electronic ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-024-01902-y

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