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18-06-2023 | Positron Emission Tomography | Original Communication

Brain FDG-PET correlates of saccadic disorders in early PSP

Authors: G. Pin, J. Labouré, E. Guedj, O. Felician, S. Grimaldi, J. P. Azulay, M. Ceccaldi, L. Koric

Published in: Journal of Neurology | Issue 10/2023

Abstract

Background

New diagnostic criteria of Progressive Supranuclear Palsy (PSP) have highlighted the interest of Eye Movement Records (EMR) at the early stage of the disease.

Objectives

To investigate the metabolic brain correlates of ocular motor dysfunction using [18F] Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in early PSP.

Methods

Retrospective observational descriptive study on longitudinal data with patients who underwent EMR and FDG-PET at the stage of suggestive and possible PSP according to Movement Disorders Society criteria. Longitudinal follow-up enables to confirm diagnosis of probable PSP. Using the Statistical Parametric Mapping software, we performed whole-brain voxel-based correlations between oculomotor variables and FDG-PET metabolism.

Results

Thirty-seven patients with early PSP who fulfilled criteria of probable PSP during the follow-up were included. Decrease in the gain of vertical saccades correlated with reduced metabolism in Superior Colliculi (SC). We also found a positive correlation between mean velocity of horizontal saccades and SC metabolism as well as dorsal nuclei in the pons. Finally, increase in horizontal saccades latencies correlated with decrease of posterior parietal metabolism.

Conclusions

These findings suggest the early involvement of SC in saccadic dysfunction in the course of PSP.

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Title: Brain FDG-PET correlates of saccadic disorders in early PSP
Authors: G. Pin
J. Labouré
E. Guedj
O. Felician
S. Grimaldi
J. P. Azulay
M. Ceccaldi
L. Koric
Publication date: 18-06-2023
Publisher: Springer Berlin Heidelberg
Keywords: Positron Emission Tomography
Progressive Supranuclear Palsy
Atypical Parkinsonism
Published in: Journal of Neurology / Issue 10/2023
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-023-11824-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Brain FDG-PET correlates of saccadic disorders in early PSP

Abstract

Background

Objectives

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusions

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