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Angiogenesis
Published in: Angiogenesis 2/2020

01-05-2020 | Perspective

Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis

Author: Coert Margadant

Published in: Angiogenesis | Issue 2/2020

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Abstract

Vascular endothelial growth factor-A (VEGF-A/VEGF) interaction with VEGF receptor 2 (VEGFR2) is key for sprouting angiogenesis in health and disease. VEGF/VEGFR2 signaling promotes endothelial proliferation and migration, as well as the hierarchical organization into leader (tip) and follower (stalk) cells via a dynamic interplay with Notch. Recent studies reveal novel molecular mechanisms to fine-tune VEGF/Notch signaling and tip/stalk cell function during sprouting angiogenesis.
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Metadata
Title
Positive and negative feedback mechanisms controlling tip/stalk cell identity during sprouting angiogenesis
Author
Coert Margadant
Publication date
01-05-2020
Publisher
Springer Netherlands
Published in
Angiogenesis / Issue 2/2020
Print ISSN: 0969-6970
Electronic ISSN: 1573-7209
DOI
https://doi.org/10.1007/s10456-020-09706-0

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