Published in:
01-06-2016
Polymorphisms of the Stem Cell Marker Gene CD133 and the Risk of Lung Cancer in Chinese Population
Published in: Lung | Issue 3/2016
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Objective
To explore the association of functional single-nucleotide polymorphisms (SNPs) of CD133 with the risk of lung cancer.
Methods
We conducted a hospital-based, case–control study of 1017 lung cancer patients and 1035 cancer-free controls frequency-matched by age and sex. Four functional CD133 SNPs (rs2240688 A > C, rs10022537 T > A, rs7686732 C > G, and rs3130 C > T) were selected and genotyped. Unconditional univariate and multivariate logistic regression analyses were carried out to evaluate the associations of genotypes of CD133 SNPs with lung cancer risk.
Results
Compared with rs2240688 AA genotype, the variant AC/CC genotypes were associated with a statistically increased risk of lung cancer under a recessive model (adjusted odds ratio 1.19; 95 % confidence interval 1.01–1.42). The risk remained in patients with other histology types, but not with adenocarcinoma and squamous cell cancers.
Conclusions
These findings suggest that SNP rs2240688 A > C of CD133 may be a potential biomarker for genetic susceptibility to lung cancer, but require further research with larger populations.