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BMC Women's Health
Published in: BMC Women's Health 1/2021

Open Access 01-12-2021 | Polycystic Ovary Syndrome | Research article

Premenstrual dysphoric disorder is associated with the longer length from clitoris to urethra

Authors: Zheng Li, Meng-jiao Xu, Ying Jin, Bing-gen Zhu

Published in: BMC Women's Health | Issue 1/2021

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Abstract

Background

Premenstrual dysphoric disorder (PMDD) is a common, recently recognized, psychiatric condition among reproductive women, reflecting abnormal responsivity to ovarian steroids. Moreover, the potential organizational effect of prenatal sex hormones during PMDD has got attentions, but there have been considerably less of researches on this topic. The aim of this research was to investigate the possible role of prenatal androgen in the PMDD.

Methods

Anogenital distance (AGD), the distance between a woman’s clitoris and her urethral meatus (CUMD), left and right 2D:4D ratios were measured in 77 subjects (25 patients with PMDD), as these anthropometric indicators are considered to indirectly reflect prenatal androgen exposures in utero.

Results

Patients with PMDD had a longer CUMD than controls (25.03 ± 4.73 vs. 22.07 ± 4.30, P = 0.008), while there were no significant difference between PMDD group and control group in the AGD and right and left 2D:4D ratios.

Conclusion

Atypical high prenatal androgen exposure might predispose individuals to be susceptible to PMDD.
Appendix
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Metadata
Title
Premenstrual dysphoric disorder is associated with the longer length from clitoris to urethra
Authors
Zheng Li
Meng-jiao Xu
Ying Jin
Bing-gen Zhu
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Women's Health / Issue 1/2021
Electronic ISSN: 1472-6874
DOI
https://doi.org/10.1186/s12905-021-01403-4

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