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Open Access 31-01-2023 | Polio Virus | Correspondence

Archival wild-type poliovirus 1 infected central nervous system tissues of the pre-vaccination era in Switzerland reveal a distinct virus genotype

Authors: Nicole Wildi, Stefano Bagatella, Michel C. Koch, Anna Oevermann, Torsten Seuberlich

Published in: Acta Neuropathologica | Issue 3/2023

Excerpt

Poliovirus 1 (PV1), a member of the species Enterovirus C, causes poliomyelitis and has almost been eradicated globally following world-wide vaccination campaigns since the 1960s. Yet, rare fatal cases due to infections with wild-type PV1 or circulating vaccine-derived poliovirus are still being reported in some developing countries [6, 7]. PV1 is among the bests studied RNA viruses; however, PV1 genomes have been sequenced mostly from feces samples or after passage in cell culture and to our knowledge never from nervous tissue directly. Thus, we know little about the genetic diversity of neurovirulent wild-type strains in the CNS of affected patients in the pre-vaccination era. …

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Title: Archival wild-type poliovirus 1 infected central nervous system tissues of the pre-vaccination era in Switzerland reveal a distinct virus genotype
Authors: Nicole Wildi
Stefano Bagatella
Michel C. Koch
Anna Oevermann
Torsten Seuberlich
Publication date: 31-01-2023
Publisher: Springer Berlin Heidelberg
Keywords: Polio Virus
Vaccination
Published in: Acta Neuropathologica / Issue 3/2023
Print ISSN: 0001-6322
Electronic ISSN: 1432-0533
DOI: https://doi.org/10.1007/s00401-023-02545-5

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Archival wild-type poliovirus 1 infected central nervous system tissues of the pre-vaccination era in Switzerland reveal a distinct virus genotype

Excerpt

Keynote webinar | Spotlight on medication adherence

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