Published in:
Open Access
01-12-2021 | Pneumococcus | Research
Effectiveness of a 23-valent pneumococcal polysaccharide vaccine for the prevention of pneumococcal pneumonia in the elderly with chronic respiratory diseases: a case–control study of a single center
Authors:
Toshihiro Masuda, Eiji Nakatani, Toshihiro Shirai, Taisuke Akamatsu, Kanami Tamura, Shingo Takahashi, Yuko Tanaka, Hirofumi Watanabe, Yoshinari Endo, Takahito Suzuki, Mika Saigusa, Akito Yamamoto, Satoru Morita, Yoko Sato, Kazuhiro Asada
Published in:
BMC Pulmonary Medicine
|
Issue 1/2021
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Abstract
Background
The effectiveness of the 23-valent pneumococcal polysaccharide vaccine (PPSV23) in preventing pneumococcal pneumonia has been controversial.
Methods
To evaluate the effectiveness of the PPSV23 in elderly outpatients with chronic respiratory diseases, we carried out a case–control study, including 4128 outpatients aged ≥ 65 years, in the respiratory department.
Results
There were 320 vaccinated patients, of which 164 were diagnosed with pneumococcal pneumonia. The adjusted odds ratio was 0.39 (95% confidence interval (CI), 0.17 to 0.89). In the subsets consisting of age groups ≥ 70 and ≥ 75 years, the adjusted odds ratio (95% CI) was respectively 0.16 (0.04 to 0.67) and 0.15 (0.02 to 1.12).
Conclusion
This real-world study suggests that PPSV23 can be useful in preventing pneumococcal pneumonia in the elderly with chronic respiratory diseases.