Published in:
01-04-2021 | Platelet Transfusion | Original Article
Effect of donor type on volume of blood transfusions required after allogeneic hematopoietic cell transplantation
Authors:
Saiko Kurosawa, Takuhiro Yamaguchi, Saori Nakabayashi, Moemi Kasane, Misato Tsubokura, Nao Iwashita, Yuki Minakawa, Ryuzaburo Ohtake, Kimihiko Kawamura, Yukiko Nishioka, Wataru Takeda, Tuneaki Hirakawa, Jun Aoki, Ayumu Ito, Takashi Tanaka, Yoshihiro Inamoto, Sung-Won Kim, Minoru Kojima, Minoko Takanashi, Takahiro Fukuda
Published in:
International Journal of Hematology
|
Issue 4/2021
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Abstract
We reviewed blood product use in 729 consecutive allogeneic hematopoietic cell transplantation (allo-HCT) recipients at our center to assess the volume of red blood cells (RBCs) and platelets required after allo-HCT. The median number of bags required by day 30 was 4 for RBCs (range 0–22) and 9.5 for platelets (0–53). Multivariate analysis showed that related peripheral blood stem cell transplantation (PBSCT) required a significantly lower RBC transfusion volume by day 30 compared to unrelated bone marrow transplantation (UBMT). PBSCT from haplo-identical related donors and cord blood transplantation (CBT) required a significantly greater RBC transfusion volume. For platelet transfusion, related and unrelated PBSCT required a significantly lower volume than UBMT, and CBT a greater volume. Other factors independently associated with greater RBC transfusion volume were male sex, disease status other than complete remission, and major ABO mismatch. For platelet transfusion, these were male sex, disease status, and HCT-specific comorbidity index of 1. Although the burden of blood transfusions may not be the most important factor when choosing a donor type, our findings may provide a foundation for nationwide strategies to prepare blood products and inform aspects of national healthcare expenditures.