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Internal and Emergency Medicine
Published in: Internal and Emergency Medicine 2/2008

01-06-2008 | CE - Letter to the Editor

Platelet dysfunction and other hemostatic disorders in women with menorrhagia: the utility of whole blood lumi-aggregometer

Authors: O. Meltem Akay, Fezan Mutlu, Zafer Gulbas

Published in: Internal and Emergency Medicine | Issue 2/2008

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Excerpt

Menorrhagia is a very common clinical problem among women of reproductive age and is unexplained in more than 50% of cases [1]. The widely accepted clinical definition of menorrhagia is blood loss of 80 ml, or more, per period [2]. Underlying bleeding disorders, such as von Willebrand disease (VWD) and platelet abnormalities may present as menorrhagia. However, the relevance of a systemic screening for hemostasis in women with menorrhagia remains controversial [3]. Here, we describe the findings of a prospective study investigating the frequency of platelet dysfunction and other hemostatic defects among women with unexplained menorrhagia using whole blood lumi-aggregometer. …
Literature
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Philipp CS, Dilley A, Miller CH et al (2003) Platelet functional defects in women with unexplained menorrhagia. J Thromb Haemost 1:477–484PubMedCrossRef
2.
Iyer V, Farquhar C, Jepson R (2000) Oral contraceptive pills for heavy menstrual bleeding. Cochrane Database Syst Rev 2:CD000154PubMed
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James A, Matchar DB, Myers ER (2004) Testing for von Willebrand disease in women with menorrhagia: a systemic review. Obstet Gynecol 104:381–388PubMed
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Fraser I, McCarron G, Markham R, Resta T, Watts A (1986) Measured menstrual blood loss in women with menorrhagia associated with pelvic disease or coagulation disorder. Obstet Gynecol 68:630–633PubMed
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Mandalaki T, Louizou C, Dmitriadou C, Symeonides PH (1980) Variations in factor VIII during the menstrual cycle in normal women. N Engl J Med 302:1093PubMed
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Kadir RA, Economides DL, Sabin CA, Owens D, Lee CA (1998) Frequency of inherited bleeding disorders in women with menorrhagia. Lancet 351:485–489PubMedCrossRef
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Edlund M, Blomback M, von Schoultz B, Andersson O (1996) On the value of menorrhagia as a predictor for coagulation disorders. Am J Hematol 53:234–238PubMedCrossRef
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Dilley A, Drews C, Miller C et al (2001) von Willebrand disease and other inherited bleeding disorders in women with diagnosed menorrhagia. Obstet Gynecol 97:630–636PubMedCrossRef
Metadata
Title
Platelet dysfunction and other hemostatic disorders in women with menorrhagia: the utility of whole blood lumi-aggregometer
Authors
O. Meltem Akay
Fezan Mutlu
Zafer Gulbas
Publication date
01-06-2008
Publisher
Springer Milan
Published in
Internal and Emergency Medicine / Issue 2/2008
Print ISSN: 1828-0447
Electronic ISSN: 1970-9366
DOI
https://doi.org/10.1007/s11739-008-0105-7

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