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Journal of NeuroEngineering and Rehabilitation

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Open Access 01-12-2009 | Review

Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)

Authors: Gary W Thickbroom, Frank L Mastaglia

Published in: Journal of NeuroEngineering and Rehabilitation | Issue 1/2009

Abstract

There has been considerable interest in trialing NBS in a range of neurological conditions, and in parallel the range of NBS techniques available continues to expand. Underpinning this is the idea that NBS modulates neuroplasticity and that plasticity is an important contributor to functional recovery after brain injury and to the pathophysiology of neurological disorders. However while the evidence for neuroplasticity and its varied mechanisms is strong, the relationship to functional outcome is less clear and the clinical indications remain to be determined. To be maximally effective, the application of NBS techniques will need to be refined to take into account the diversity of neurological symptoms, the fundamental differences between acute, longstanding and chronic progressive disease processes, and the differential part played by functional and dysfunctional plasticity in diseases of the brain and spinal cord.

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Title: Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)
Authors: Gary W Thickbroom
Frank L Mastaglia
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Journal of NeuroEngineering and Rehabilitation / Issue 1/2009
Electronic ISSN: 1743-0003
DOI: https://doi.org/10.1186/1743-0003-6-4

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Plasticity in neurological disorders and challenges for noninvasive brain stimulation (NBS)

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