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01-12-2021 | Plasmodium Falciparum | Commentary

Can complement fix placental malaria?

Authors: Justin Y. A. Doritchamou, Patrick E. Duffy

Published in: BMC Medicine | Issue 1/2021

Excerpt

Placental malaria (PM) is a deadly public health problem caused by the human parasite Plasmodium falciparum, and this scourge will get worse as existing control measures lose potency. Our understanding of PM pathogenesis suggests a vaccine is feasible, but first-generation candidates yielded only modest variant-specific activity in early trials. In this issue of BMC Medicine, Opi and colleagues provide evidence for a heretofore unrecognized mechanism of protective immunity, whereby the neutralizing activity of antibody against PM parasites is enhanced by fixing the complement component C1q [1]. …

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10.

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Title: Can complement fix placental malaria?
Authors: Justin Y. A. Doritchamou
Patrick E. Duffy
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Plasmodium Falciparum
Malaria
Published in: BMC Medicine / Issue 1/2021
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-021-02083-5

At a glance: The STEP trials

Springer Medicine

Can complement fix placental malaria?

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

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