Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Malaria Journal
Published in: Malaria Journal 1/2015

Open Access 01-12-2015 | Research

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

Authors: Maya A Olshina, Fiona Angrisano, Danushka S Marapana, David T Riglar, Kartik Bane, Wilson Wong, Bruno Catimel, Meng-Xin Yin, Andrew B Holmes, Friedrich Frischknecht, David R Kovar, Jake Baum

Published in: Malaria Journal | Issue 1/2015

Login to get access

Abstract

Background

Gliding motility in Plasmodium parasites, the aetiological agents of malaria disease, is mediated by an actomyosin motor anchored in the outer pellicle of the motile cell. Effective motility is dependent on a parasite myosin motor and turnover of dynamic parasite actin filaments. To date, however, the basis for directional motility is not known. Whilst myosin is very likely orientated as a result of its anchorage within the parasite, how actin filaments are orientated to facilitate directional force generation remains unexplained. In addition, recent evidence has questioned the linkage between actin filaments and secreted surface antigens leaving the way by which motor force is transmitted to the extracellular milieu unknown. Malaria parasites possess a markedly reduced repertoire of actin regulators, among which few are predicted to interact with filamentous (F)-actin directly. One of these, PF3D7_1251200, shows strong homology to the coronin family of actin-filament binding proteins, herein referred to as PfCoronin.

Methods

Here the N terminal beta propeller domain of PfCoronin (PfCor-N) was expressed to assess its ability to bind and bundle pre-formed actin filaments by sedimentation assay, total internal reflection fluorescence (TIRF) microscopy and confocal imaging as well as to explore its ability to bind phospholipids. In parallel a tagged PfCoronin line in Plasmodium falciparum was generated to determine the cellular localization of the protein during asexual parasite development and blood-stage merozoite invasion.

Results

A combination of biochemical approaches demonstrated that the N-terminal beta-propeller domain of PfCoronin is capable of binding F-actin and facilitating formation of parallel filament bundles. In parasites, PfCoronin is expressed late in the asexual lifecycle and localizes to the pellicle region of invasive merozoites before and during erythrocyte entry. PfCoronin also associates strongly with membranes within the cell, likely mediated by interactions with phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) at the plasma membrane.

Conclusions

These data suggest PfCoronin may fulfil a key role as the critical determinant of actin filament organization in the Plasmodium cell. This raises the possibility that macro-molecular organization of actin mediates directional motility in gliding parasites.
Appendix
Available only for authorised users
Literature
1.
Cowman AF, Berry D, Baum J (2012) The cellular and molecular basis for malaria parasite invasion of the human red blood cell. J Cell Biol 198:961–971PubMedCentralPubMedCrossRef
2.
Prudencio M, Rodriguez A, Mota MM (2006) The silent path to thousands of merozoites: the Plasmodium liver stage. Nat Rev Microbiol 4:849–856PubMedCrossRef
3.
Baum J, Gilberger T-W, Frischknecht F, Meissner M (2008) Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma. Trends Parasitol 24:557–563PubMedCrossRef
4.
5.
Frénal K, Polonais V, Marq J-B, Stratmann R, Limenitakis J, Soldati-Favre D (2010) Functional dissection of the apicomplexan glideosome molecular architecture. Cell Host Microbe 8:343–357PubMedCrossRef
6.
Pinder JC, Fowler RE, Dluzewski AR, Bannister LH, Lavin FM, Mitchell GH et al (1998) Actomyosin motor in the merozoite of the malaria parasite, Plasmodium falciparum: implications for red cell invasion. J Cell Sci 111:1831–1839PubMed
7.
Jewett TJ, Sibley LD (2003) Aldolase forms a bridge between cell surface adhesins and the actin cytoskeleton in apicomplexan parasites. Mol Cell 11:885–894PubMedCrossRef
8.
Wang J, Morris AJ, Tolan DR, Pagliaro L (1996) The molecular nature of the F-actin binding activity of aldolase revealed with site-directed mutants. J Biol Chem 271:6861–6865PubMedCrossRef
9.
Kudryashev M, Lepper S, Baumeister W, Cyrklaff M, Frischknecht F (2010) Geometric constrains for detecting short actin filaments by cryogenic electron tomography. PMC Biophys 3:6PubMedCentralPubMedCrossRef
10.
Angrisano F, Riglar DT, Sturm A, Volz JC, Delves MJ, Zuccala ES et al (2012) Spatial localisation of actin filaments across developmental stages of the malaria parasite. PLoS One 7:e32188PubMedCentralPubMedCrossRef
11.
12.
Egarter S, Andenmatten N, Jackson AJ, Whitelaw JA, Pall G, Black JA et al (2014) The Toxoplasma Acto-MyoA motor complex is important but not essential for gliding motility and host cell invasion. PLoS One 9:e91819PubMedCentralPubMedCrossRef
13.
Miller LH, Aikawa M, Johnson JG, Shiroishi T (1979) Interaction between cytochalasin B-treated malarial parasites and erythrocytes. Attachment and junction formation. J Exp Med 149:172–184PubMedCrossRef
14.
Mizuno Y, Makioka A, Kawazu S, Kano S, Kawai S, Akaki M et al (2002) Effect of jasplakinolide on the growth, invasion, and actin cytoskeleton of Plasmodium falciparum. Parasitol Res 88:844–848PubMedCrossRef
15.
Schuler H, Matuschewski K (2006) Regulation of apicomplexan microfilament dynamics by a minimal set of actin-binding proteins. Traffic 7:1433–1439PubMedCrossRef
16.
Baum J, Papenfuss AT, Baum B, Speed TP, Cowman AF (2006) Regulation of apicomplexan actin-based motility. Nat Rev Microbiol 4:621–628PubMedCrossRef
17.
Olshina MA, Wong W, Baum J (2012) Holding back the microfilament—structural insights into actin and the actin-monomer-binding proteins of apicomplexan parasites. IUBMB Life 64:370–377PubMedCrossRef
18.
Baum J, Tonkin CJ, Paul AS, Rug M, Smith BJ, Gould SB et al (2008) A malaria parasite formin regulates actin polymerization and localizes to the parasite-erythrocyte moving junction during invasion. Cell Host Microb 3:188–198CrossRef
19.
Kursula I, Kursula P, Ganter M, Panjikar S, Matuschewski K, Schuler H (2008) Structural basis for parasite-specific functions of the divergent profilin of Plasmodium falciparum. Structure 16:1638–1648PubMedCrossRef
20.
Wong W, Webb AI, Olshina MA, Infusini G, Tan YH, Hanssen E et al (2014) A mechanism for actin filament severing by malaria parasite actin depolymerizing factor 1 via a low affinity binding interface. J Biol Chem 289:4043–4054PubMedCentralPubMedCrossRef
21.
Singh BK, Sattler JM, Chatterjee M, Huttu J, Schüler H, Kursula I (2011) Crystal structures explain functional differences in the two actin depolymerization factors of the malaria parasite. J Biol Chem 286:28256–28264PubMedCentralPubMedCrossRef
22.
Makkonen M, Bertling E, Chebotareva NA, Baum J, Lappalainen P (2013) Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism. J Biol Chem 288:984–994PubMedCentralPubMedCrossRef
23.
Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R et al (2010) Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector. J Biol Chem 285:11572–11583PubMedCentralPubMedCrossRef
24.
Ganter M, Rizopoulos Z, Schuler H, Matuschewski K (2015) Pivotal and distinct role for Plasmodium actin capping protein alpha during blood infection of the malaria parasite. Mol Microbiol 96:84–94PubMedCentralPubMedCrossRef
25.
Tardieux I, Liu X, Poupel O, Parzy D, Dehoux P, Langsley G (1998) A Plasmodium falciparum novel gene encoding a coronin-like protein which associates with actin filaments. FEBS Lett 441:251–256PubMedCrossRef
26.
27.
Eckert C, Hammesfahr B, Kollmar M (2011) A holistic phylogeny of the coronin gene family reveals an ancient origin of the tandem-coronin, defines a new subfamily, and predicts protein function. BMC Evol Biol 11:268PubMedCentralPubMedCrossRef
28.
Chan KT, Creed SJ, Bear JE (2011) Unraveling the enigma: progress towards understanding the coronin family of actin regulators. Trends Cell Biol 21:481–488PubMedCentralPubMedCrossRef
29.
Appleton BA, Wu P, Wiesmann C (2006) The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Structure 14:87–96PubMedCrossRef
30.
Gatfield J, Albrecht I, Zanolari B, Steinmetz MO, Pieters J (2005) Association of the leukocyte plasma membrane with the actin cytoskeleton through coiled coil-mediated trimeric coronin 1 molecules. Mol Biol Cell 16:2786–2798PubMedCentralPubMedCrossRef
31.
Kammerer RA, Kostrewa D, Progias P, Honnappa S, Avila D, Lustig A et al (2005) A conserved trimerization motif controls the topology of short coiled coils. Proc Natl Acad Sci USA 102:13891–13896PubMedCentralPubMedCrossRef
32.
Salamun J, Kallio JP, Daher W, Soldati-Favre D, Kursula I (2014) Structure of Toxoplasma gondii coronin, an actin-binding protein that relocalizes to the posterior pole of invasive parasites and contributes to invasion and egress. FASEB J 28:4729–4747PubMedCrossRef
33.
Spudich JA, Watt S (1971) The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J Biol Chem 246:4866–4871PubMed
34.
Wachsstock DH, Schwartz WH, Pollard TD (1993) Affinity of alpha-actinin for actin determines the structure and mechanical properties of actin filament gels. Biophys J 65:205–214PubMedCentralPubMedCrossRef
35.
Neirynck K, Waterschoot D, Vandekerckhove J, Ampe C, Rommelaere H (2006) Actin interacts with CCT via discrete binding sites: a binding transition-release model for CCT-mediated actin folding. J Mol Biol 355:124–138PubMedCrossRef
36.
de Chaumont F, Dallongeville S, Chenouard N, Herve N, Pop S, Provoost T et al (2012) Icy: an open bioimage informatics platform for extended reproducible research. Nat Methods 9:690–696PubMedCrossRef
37.
Kovar DR, Kuhn JR, Tichy AL, Pollard TD (2003) The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin. J Cell Biol 161:875–887PubMedCentralPubMedCrossRef
38.
Neidt EM, Skau CT, Kovar DR (2008) The cytokinesis formins from the nematode worm and fission yeast differentially mediate actin filament assembly. J Biol Chem 283:23872–23883PubMedCentralPubMedCrossRef
39.
Boyle MJ, Wilson DW, Richards JS, Riglar DT, Tetteh KK, Conway DJ et al (2010) Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development. Proc Natl Acad Sci USA 107:14378–14383PubMedCentralPubMedCrossRef
40.
Baum J, Richard D, Healer J, Rug M, Krnajski Z, Gilberger T-W et al (2006) A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites. J Biol Chem 281:5197–5208PubMedCrossRef
41.
Riglar DT, Richard D, Wilson DW, Boyle MJ, Dekiwadia C, Turnbull L et al (2011) Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte. Cell Host Microbe 9:9–20PubMedCrossRef
42.
Lambros C, Vanderberg JP (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65:418–420PubMedCrossRef
43.
Boyle MJ, Richards JS, Gilson PR, Chai W, Beeson JG (2010) Interactions with heparin-like molecules during erythrocyte invasion by Plasmodium falciparum merozoites. Blood 115:4559–4568PubMedCrossRef
44.
Richard D, MacRaild CA, Riglar DT, Chan J-A, Foley M, Baum J et al (2010) Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites. J Biol Chem 285:14815–14822PubMedCentralPubMedCrossRef
45.
Conway SJ, Gardiner J, Grove SJ, Johns MK, Lim ZY, Painter GF et al (2010) Synthesis and biological evaluation of phosphatidylinositol phosphate affinity probes. Org Biomol Chem 8:66–76PubMedCrossRef
46.
Catimel B, Kapp E, Yin MX, Gregory M, Wong LS, Condron M et al (2013) The PI(3)P interactome from a colon cancer cell. J Proteomics 82:35–51PubMedCrossRef
47.
Diaz SA, Martin SR, Grainger M, Howell SA, Green JL, Holder AA (2014) Plasmodium falciparum aldolase and the C-terminal cytoplasmic domain of certain apical organellar proteins promote actin polymerization. Mol Biochem Parasitol 197:9–14PubMedCentralPubMedCrossRef
48.
Chan KT, Roadcap DW, Holoweckyj N, Bear JE (2012) Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin. Biochem J 444:89–96PubMedCentralPubMedCrossRef
49.
Gandhi M, Jangi M, Goode BL (2010) Functional surfaces on the actin-binding protein coronin revealed by systematic mutagenesis. J Biol Chem 285:34899–34908PubMedCentralPubMedCrossRef
50.
Skau CT, Courson DS, Bestul AJ, Winkelman JD, Rock RS, Sirotkin V et al (2011) Actin filament bundling by fimbrin is important for endocytosis, cytokinesis, and polarization in fission yeast. J Biol Chem 286:26964–26977PubMedCentralPubMedCrossRef
51.
Xu J, Wirtz D, Pollard TD (1998) Dynamic cross-linking by alpha-actinin determines the mechanical properties of actin filament networks. J Biol Chem 273:9570–9576PubMedCrossRef
52.
Falzone TT, Lenz M, Kovar DR, Gardel ML (2012) Assembly kinetics determine the architecture of alpha-actinin crosslinked F-actin networks. Nat Commun 3:861PubMedCentralPubMedCrossRef
53.
Goode BL, Wong JJ, Butty AC, Peter M, McCormack AL, Yates JR et al (1999) Coronin promotes the rapid assembly and cross-linking of actin filaments and may link the actin and microtubule cytoskeletons in yeast. J Cell Biol 144:83–98PubMedCentralPubMedCrossRef
54.
Asano S, Mishima M, Nishida E (2001) Coronin forms a stable dimer through its C-terminal coiled coil region: an implicated role in its localization to cell periphery. Genes Cells 6:225–235PubMedCrossRef
55.
Tempel M, Isenberg G, Sackmann E (1996) Temperature-induced sol-gel transition and microgel formation in alpha-actinin cross-linked actin networks: a rheological study. Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics 54:1802–1810PubMed
56.
Higaki T, Kutsuna N, Sano T, Kondo N, Hasezawa S (2010) Quantification and cluster analysis of actin cytoskeletal structures in plant cells: role of actin bundling in stomatal movement during diurnal cycles in Arabidopsis guard cells. Plant J 61:156–165PubMedCrossRef
57.
Khurana P, Henty JL, Huang S, Staiger AM, Blanchoin L, Staiger CJ (2010) Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Plant Cell 22:2727–2748PubMedCentralPubMedCrossRef
58.
Bozdech Z, Zhu J, Joachimiak MP, Cohen FE, Pulliam B, DeRisi JL (2003) Expression profiling of the schizont and trophozoite stages of Plasmodium falciparum with a long-oligonucleotide microarray. Genome Biol 4:R9PubMedCentralPubMedCrossRef
59.
Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW et al (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419:498–511PubMedCrossRef
60.
61.
Crewther PE, Culvenor JG, Silva A, Cooper JA, Anders RF (1990) Plasmodium falciparum: two antigens of similar size are located in different compartments of the rhoptry. Exp Parasitol 70:193–206PubMedCrossRef
62.
Triglia T, Healer J, Caruana SR, Hodder AN, Anders RF, Crabb BS et al (2000) Apical membrane antigen 1 plays a central role in erythrocyte invasion by Plasmodium species. Mol Microbiol 38:706–718PubMedCrossRef
63.
Wong W, Skau CT, Marapana DS, Hanssen E, Taylor NL, Riglar DT et al (2011) Minimal requirements for actin filament disassembly revealed by structural analysis of malaria parasite actin-depolymerizing factor 1. Proc Natl Acad Sci USA 108:9869–9874PubMedCentralPubMedCrossRef
64.
Kauth CW, Woehlbier U, Kern M, Mekonnen Z, Lutz R, Mucke N et al (2006) Interactions between merozoite surface proteins 1, 6, and 7 of the malaria parasite Plasmodium falciparum. J Biol Chem 281:31517–31527PubMedCrossRef
65.
Tsujita K, Itoh T, Kondo A, Oyama M, Kozuka-Hata H, Irino Y et al (2010) Proteome of acidic phospholipid-binding proteins: spatial and temporal regulation of Coronin 1A by phosphoinositides. J Biol Chem 285:6781–6789PubMedCentralPubMedCrossRef
66.
Catimel B, Schieber C, Condron M, Patsiouras H, Connolly L, Catimel J et al (2008) The PI(3,5)P2 and PI(4,5)P2 interactomes. J Proteome Res 7:5295–5313PubMedCrossRef
67.
Schüler H, Mueller A-K, Matuschewski K (2005) Unusual properties of Plasmodium falciparum actin: new insights into microfilament dynamics of apicomplexan parasites. FEBS Lett 579:655–660PubMedCrossRef
68.
Schmitz S, Schaap IA, Kleinjung J, Harder S, Grainger M, Calder L et al (2010) Malaria parasite actin polymerization and filament structure. J Biol Chem 285:36577–36585PubMedCentralPubMedCrossRef
69.
Schmitz S, Grainger M, Howell S, Calder LJ, Gaeb M, Pinder JC et al (2005) Malaria parasite actin filaments are very short. J Mol Biol 349:113–125PubMedCrossRef
70.
Vahokoski J, Bhargav SP, Desfosses A, Andreadaki M, Kumpula EP, Martinez SM et al (2014) Structural differences explain diverse functions of Plasmodium actins. PLoS Pathog 10:e1004091PubMedCentralPubMedCrossRef
71.
Skillman KM, Ma CI, Fremont DH, Diraviyam K, Cooper JA, Sept D et al (2013) The unusual dynamics of parasite actin result from isodesmic polymerization. Nat Commun 4:2285PubMedCentralPubMedCrossRef
72.
Skillman KM, Diraviyam K, Khan A, Tang K, Sept D, Sibley LD (2011) Evolutionarily divergent, unstable filamentous actin is essential for gliding motility in apicomplexan parasites. PLoS Pathog 7:e1002280PubMedCentralPubMedCrossRef
73.
Sahoo N, Beatty W, Heuser J, Sept D, Sibley LD (2006) Unusual kinetic and structural properties control rapid assembly and turnover of actin in the parasite Toxoplasma gondii. Mol Biol Cell 17:895–906PubMedCentralPubMedCrossRef
74.
Field SJ, Pinder JC, Clough B, Dluzewski AR, Wilson RJ, Gratzer WB (1993) Actin in the merozoite of the malaria parasite, Plasmodium falciparum. Cell Motil Cytoskelet 25:43–48CrossRef
75.
Dobrowolski JM, Sibley LD (1996) Toxoplasma invasion of mammalian cells is powered by the actin cytoskeleton of the parasite. Cell 84:933–939PubMedCrossRef
76.
Wetzel DM, Håkansson S, Hu K, Roos D, Sibley LD (2003) Actin filament polymerization regulates gliding motility by apicomplexan parasites. Mol Biol Cell 14:396–406PubMedCentralPubMedCrossRef
77.
Bosch J, Turley S, Roach CM, Daly TM, Bergman LW, Hol WG (2007) The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery. J Mol Biol 372:77–88PubMedCentralPubMedCrossRef
78.
Sheiner L, Santos JM, Klages N, Parussini F, Jemmely N, Friedrich N et al (2010) Toxoplasma gondii transmembrane microneme proteins and their modular design. Mol Microbiol 77:912–929PubMedCentralPubMed
79.
Oku T, Itoh S, Ishii R, Suzuki K, Nauseef WM, Toyoshima S et al (2005) Homotypic dimerization of the actin-binding protein p57/coronin-1 mediated by a leucine zipper motif in the C-terminal region. Biochem J 387:325–331PubMedCentralPubMedCrossRef
80.
Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH (2008) Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. J Mol Biol 376:607–613PubMedCentralPubMedCrossRef
Metadata
Title
Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites
Authors
Maya A Olshina
Fiona Angrisano
Danushka S Marapana
David T Riglar
Kartik Bane
Wilson Wong
Bruno Catimel
Meng-Xin Yin
Andrew B Holmes
Friedrich Frischknecht
David R Kovar
Jake Baum
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2015
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-015-0801-5

Other articles of this Issue 1/2015

Malaria Journal 1/2015 Go to the issue

Research

Diagnostic performance of a novel loop-mediated isothermal amplification (LAMP) assay targeting the apicoplast genome for malaria diagnosis in a field setting in sub-Saharan Africa

Research

Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013

Research

Malaria prevalence in Bata district, Equatorial Guinea: a cross-sectional study

Review

Monitoring of efficacy and safety of artemisinin-based anti-malarials for treatment of uncomplicated malaria: a review of evidence of implementation of anti-malarial therapeutic efficacy trials in Tanzania

Meeting report

Disruptive technology for vector control: the Innovative Vector Control Consortium and the US Military join forces to explore transformative insecticide application technology for mosquito control programmes

Research

Surveillance for the safety and effectiveness of artemether-lumefantrine in patients with uncomplicated Plasmodium falciparum malaria in the USA: a descriptive analysis
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits