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Fibrogenesis & Tissue Repair
Published in: Fibrogenesis & Tissue Repair 1/2011

Open Access 01-12-2011 | Review

Plasma and cellular fibronectin: distinct and independent functions during tissue repair

Authors: Wing S To, Kim S Midwood

Published in: Fibrogenesis & Tissue Repair | Issue 1/2011

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Abstract

Fibronectin (FN) is a ubiquitous extracellular matrix (ECM) glycoprotein that plays vital roles during tissue repair. The plasma form of FN circulates in the blood, and upon tissue injury, is incorporated into fibrin clots to exert effects on platelet function and to mediate hemostasis. Cellular FN is then synthesized and assembled by cells as they migrate into the clot to reconstitute damaged tissue. The assembly of FN into a complex three-dimensional matrix during physiological repair plays a key role not only as a structural scaffold, but also as a regulator of cell function during this stage of tissue repair. FN fibrillogenesis is a complex, stepwise process that is strictly regulated by a multitude of factors. During fibrosis, there is excessive deposition of ECM, of which FN is one of the major components. Aberrant FN-matrix assembly is a major contributing factor to the switch from normal tissue repair to misregulated fibrosis. Understanding the mechanisms involved in FN assembly and how these interplay with cellular, fibrotic and immune responses may reveal targets for the future development of therapies to regulate aberrant tissue-repair processes.
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Metadata
Title
Plasma and cellular fibronectin: distinct and independent functions during tissue repair
Authors
Wing S To
Kim S Midwood
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Fibrogenesis & Tissue Repair / Issue 1/2011
Electronic ISSN: 1755-1536
DOI
https://doi.org/10.1186/1755-1536-4-21

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