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Current Dermatology Reports

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01-12-2019 | Pityriasis Versicolor | Infectious Disease and Dermatology (K Krishnamurthy and C Beard), Section Editors)

A Review of Botanicals Exhibiting Antifungal Activity Against Malassezia spp. Implicated in Common Skin Conditions

Authors: Stephanie K. Pintas, Cassandra L. Quave

Published in: Current Dermatology Reports | Issue 4/2019

Abstract

Purpose of Review

The integration of botanicals in commercial cosmeceuticals, personal care products, and home remedies has fostered a need for a better understanding of the potential efficacies of these interventions. This review identified plants with antifungal activity against Malassezia, a commensal yeast implicated in inflammatory skin conditions. We sought to discover plants with potent activity comparable or superior to current antifungal agents.

Recent Findings

Malassezia plays a unique role in the pathology of skin disease, encoding for extracellular lipases that initiate an inflammatory response on the surface of the skin and prevent attack through the creation of biofilms. Antifungal resistance is on the rise, with current agents demonstrating increasing minimum inhibitory concentrations when tested in vitro.

Summary

Several plant species exhibited anti-Malassezia activity, including Nyctanthes arbor-tristis, Allium sativum, and Hypericum perforatum, among others. We recommend further research aimed at identification of the plant secondary metabolites responsible for this activity.

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Title: A Review of Botanicals Exhibiting Antifungal Activity Against Malassezia spp. Implicated in Common Skin Conditions
Authors: Stephanie K. Pintas
Cassandra L. Quave
Publication date: 01-12-2019
Publisher: Springer US
Keywords: Pityriasis Versicolor
Malassezia
Atopic Dermatitis
Ketoconazole
St. John's Wort
Published in: Current Dermatology Reports / Issue 4/2019
Electronic ISSN: 2162-4933
DOI: https://doi.org/10.1007/s13671-019-00274-1

At a glance: The STEP trials

Springer Medicine

A Review of Botanicals Exhibiting Antifungal Activity Against Malassezia spp. Implicated in Common Skin Conditions

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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