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Open Access 01-12-2022 | Pituitary Adenoma | Research article

Intrasellar pressure in patients with pituitary adenoma – relation to tumour size and growth pattern

Authors: Gabriel Simander, Per Olof Eriksson, Peter Lindvall, Lars-Owe D. Koskinen

Published in: BMC Neurology | Issue 1/2022

Abstract

Background

Only a few earlier publications on intrasellar pressure (ISP) have not been able to fully clarify any association between ISP and pituitary adenoma size and growth pattern. The aim of the study was to determine if intrasellar pressure (ISP) is elevated in patients with pituitary adenoma, and if the pressure is associated with tumour size and growth pattern.

Methods

The study included 100 patients operated for suspected pituitary adenoma, who have had their ISP measured intraoperatively. All adenomas were classified on the basis of Knosp and SIPAP, from which further classification of invasiveness was performed. MRT examinations were used to calculate the tumour volume and diameter in three axes.

Results

After exclusions, 93 cases were analysed. The mean ISP was 23.0 ± 8.4 mmHg. There were positive correlations between ISP and tumour volume and tumour diameters along all three axes. Coronal tumour diameter showed the strongest correlation with ISP elevation in a multivariate effect test. Adenomas classified as parasellar invasive (Knosp grade 3–4) showed higher mean ISP than adenomas considered as non-invasive (Knosp 0–2).

Conclusions

ISP is affected by tumour anatomy and correlates positively with tumour volume. Tumour width, i.e. diameter in the coronal plane, appears to be the measure that most strongly affects the ISP. This is confirmed by the association between ISP elevation and parasellar growth.

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Title: Intrasellar pressure in patients with pituitary adenoma – relation to tumour size and growth pattern
Authors: Gabriel Simander
Per Olof Eriksson
Peter Lindvall
Lars-Owe D. Koskinen
Publication date: 01-12-2022
Publisher: BioMed Central
Keyword: Pituitary Adenoma
Published in: BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-022-02601-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Intrasellar pressure in patients with pituitary adenoma – relation to tumour size and growth pattern

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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