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Endocrine Pathology
Published in: Endocrine Pathology 2/2013

01-06-2013

Pituitary Adenoma with Mucin Cells in a Man with an Unusual Presentation of Carney Complex

Authors: Gabrielle A. Yeaney, Jillene M. Brathwaite, Matthew L. Dashnaw, G. Edward Vates, Laura M. Calvi

Published in: Endocrine Pathology | Issue 2/2013

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Abstract

We describe a 44-year-old man with infertility, acromegaly, and hypergonadotropic hypogonadism. Clinical examination of the patient revealed hyperpigmented macules on the lips, buccal mucosa, and face which were histologically confirmed as cutaneous myxomas and blue nevi. Ultrasound revealed testicular calcifications and multiple hypoechoic thyroid nodules. MR imaging showed a pituitary microadenoma and resection revealed it to be a growth hormone and prolactin-secreting adenoma with the unusual finding of admixed individual mucin-producing cells. We discuss mucin cells in pituitary adenoma, an unreported pathologic finding in a patient with Carney complex.
Literature
1.
Boikos SA, Stratakis CA. Carney complex: pathology and molecular genetics. Neuroendocrinology 2006; 83:189–199.PubMedCrossRef
2.
Casey M, Mah C, Merliss AD, Kirschner LS, Taymans SE, Denio AE, Korf B, Irvine AD, Hughes A, Carney JA, Stratakis CA, Basson CT. Identification of a novel genetic locus for familial cardiac myxomas and Carney complex. Circulation. 1998; 98: 2560–2566.PubMedCrossRef
3.
Stratakis CA, Carney JA, Lin J-P, et al. Carney complex, a familial multiple neoplasia and lentiginosis syndrome. Analysis of 11 kindreds and linkage to the short arm of chromosome 2. J Clin Invest. 1996; 97:699–705.PubMedCrossRef
4.
Stratakis CA, Kirschner LS, Carney JA. Clinical and molecular features of the Carney complex: diagnostic criteria and recommendations for patient evaluation. J Clin Endocrinol Metab. 2001; 86:4041–4046.PubMedCrossRef
5.
Stergiopoulos SG, Abu-Asab MS, Tsokos M, and Stratakis CA. Pituitary pathology in Carney complex patients. Pituitary. 2004; 7(2):73–82.PubMedCrossRef
6.
Pack SD, Kirschner LS, Pak E, Zhuang Z, Carney JA, Stratakis CA. Genetic and histologic studies of somatomammotropic pituitary tumors in patients with the “complex of spotty skin pigmentation, myxomas, endocrine overactivity and schwannomas” (Carney complex). J Clin Endocrinol Metab 2000;85:3860–3865.PubMedCrossRef
7.
Burger PC, Scheithauer BW, Vogel FS. Region of the sella turcica: adenomas producing both growth hormone and prolactin. In: Surgical pathology of the nervous system and its coverings; 4th edition. Philadelphia: Churchill Livingston; 2002:457–459.
8.
Kepes JJ. Transitional cell tumor of the pituitary gland developing from a Rathke’s cleft cyst. Cancer. 1978; 41(1):337–43.PubMedCrossRef
9.
Pearl GS, Takei Y, Kurisaka M, Seyama S, Tindall GT. Cystic prolactinoma: a variant of “transitional cell tumor” of the pituitary. Am J Surg Pathol. 1981; 5(1):85–90.PubMedCrossRef
10.
Ikeda H, Yoshimoto T, Katakura R. A case of Rathke’s cleft cyst within a pituitary adenoma presenting with acromegaly—do “transitional cell tumors of the pituitary gland” really exist? Acta Neuropathol. 1992; 83(2):211–5.PubMedCrossRef
11.
Min HS, Lee SJ, Kim SK, Park SH. Pituitary pathology with rich folliculo-stellate cells and mucin-producing epithelia arising in a 2-year-old-girl. Pathol Int. 2007; 57(9):600–5.PubMedCrossRef
12.
Scheithauer BW, Horvath E, Abel TW, Robital Y, Park SH, Osamura RY, Deal C, Lloyd RV, Kovacs K. Pituitary blastoma: a unique embryonal tumor. Pituitary. 2012;15(3):365–73.PubMedCrossRef
13.
Devnath S, Inoue K. An insight to pituitary folliculo-stellate cells. J Neuroendocrinol. 2008; 20(6):687–91.PubMedCrossRef
14.
Pery C Jr, Avallone S, Regenet N, Coron E, Le Borgne J. Intraductal papillary mucinous tumor of the pancreas in 2 twin brothers diagnosed as having the Carney complex. Pancreas. 2009; 38(2):237–9.PubMedCrossRef
15.
Gaujoux S, Tissier F, Ragazzon B, Rebours V, Saloustros E, Perlemoine K, Vincent-Dejean C, Meurette G, Cassagnau E, Dousset B, Bertagna X, Horvath A, Terris B, Carney JA, Stratakis CA, Bertherat J. Pancreatic ductal and acinar cell neoplasms in Carney complex: a possible new association. J Clin Endocrinol Metab. 2011; 96(11):E1888-95.PubMedCrossRef
Metadata
Title
Pituitary Adenoma with Mucin Cells in a Man with an Unusual Presentation of Carney Complex
Authors
Gabrielle A. Yeaney
Jillene M. Brathwaite
Matthew L. Dashnaw
G. Edward Vates
Laura M. Calvi
Publication date
01-06-2013
Publisher
Springer US
Published in
Endocrine Pathology / Issue 2/2013
Print ISSN: 1046-3976
Electronic ISSN: 1559-0097
DOI
https://doi.org/10.1007/s12022-013-9247-x

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