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Translational Neurodegeneration
Published in: Translational Neurodegeneration 1/2017

Open Access 01-12-2017 | Review

Photophobia in neurologic disorders

Authors: Yiwen Wu, Mark Hallett

Published in: Translational Neurodegeneration | Issue 1/2017

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Abstract

Photophobia is a common symptom seen in many neurologic disorders, however, its pathophysiology remains unclear. Even the term is ambiguous. In this paper, we review the epidemiology and clinical manifestations of photophobia in neurological disorders, including primary headache, blepharospasm, progressive supranuclear palsy, and traumatic brain injury, discuss the definition, etiology and pathogenesis, and summarize practical methods of diagnosis and treatment.
Literature
1.
2.
3.
4.
Hattar S, Kumar M, Park A, et al. Central projections of melanopsin-expressing retinal ganglion cells in the mouse. J Comp Neurol. 2006;497(3):326–49.CrossRefPubMedPubMedCentral
5.
Fine PG, Digre KBA. Controlled trial of regional sympatholysis in the treatment of photo-oculodynia syndrome. J Neuroophthalmol. 1995;15(2):90–4.CrossRefPubMed
6.
7.
Katz BJ, Digre KB. Diagnosis, pathophysiology, and treatment of photophobia. Surv Ophthalmol. 2016;61(4):466–77.CrossRefPubMed
8.
The International Classification of Headache Disorders, 3rd edition (beta version). Cephalalgia, 2013, 33(9): 629–808.
9.
Cvetkovic VV, Plavec D, Lovrencic-Huzjan A, et al. Prevalence and clinical characteristics of headache in adolescents: a Croatian epidemiological study. Cephalalgia. 2014;34(4):289–97.CrossRefPubMed
10.
Rasmussen BK, Jensen R, Olesen JA. Population-based analysis of the diagnostic criteria of the international headache society. Cephalalgia. 1991;11(3):129–34.CrossRefPubMed
11.
Russell MB, Rasmussen BK, Fenger K, et al. Migraine without aura and migraine with aura are distinct clinical entities: a study of four hundred and eighty-four male and female migraineurs from the general population. Cephalalgia. 1996;16(4):239–45.CrossRefPubMed
12.
Drummond PD, Woodhouse A. Painful stimulation of the forehead increases photophobia in migraine sufferers. Cephalalgia. 1993;13(5):321–4.CrossRefPubMed
13.
Vanagaite J, Pareja JA, Storen O, et al. Light-induced discomfort and pain in migraine. Cephalalgia. 1997;17(7):733–41.CrossRefPubMed
14.
Lovati C, Mariotti C, Giani L, et al. Central sensitization in photophobic and non-photophobic migraineurs: possible role of retino nuclear way in the central sensitization process. Neurol Sci. 2013;34(Suppl 1):S133–5.CrossRefPubMed
15.
Baykan B, Ekizoglu E, Karli N, et al. Characterization of Migraineurs having allodynia: results of a large population-based study. Clin J Pain. 2016;32(7):631–5.CrossRefPubMed
16.
Drummond PDA. Quantitative assessment of photophobia in migraine and tension headache. Headache. 1986;26(9):465–9.CrossRefPubMed
17.
Vingen JV, Pareja JA, Stovner LJ. Quantitative evaluation of photophobia and phonophobia in cluster headache. Cephalalgia. 1998;18(5):250–6.CrossRefPubMed
18.
Main A, Vlachonikolis I, Dowson A. The wavelength of light causing photophobia in migraine and tension-type headache between attacks. Headache. 2000;40(3):194–9.CrossRefPubMed
19.
Irimia P, Cittadini E, Paemeleire K, et al. Unilateral photophobia or phonophobia in migraine compared with trigeminal autonomic cephalalgias. Cephalalgia. 2008;28(6):626–30.CrossRefPubMed
20.
Cittadini E, Goadsby PJ. Hemicrania continua: a clinical study of 39 patients with diagnostic implications. Brain. 2010;133(Pt 7):1973–86.CrossRefPubMed
21.
Cohen AS, Matharu MS, Goadsby PJ. Short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) or cranial autonomic features (SUNA)--a prospective clinical study of SUNCT and SUNA. Brain. 2006;129(Pt 10):2746–60.CrossRefPubMed
22.
23.
Adams WH, Digre KB, Patel BC, et al. The evaluation of light sensitivity in benign essential blepharospasm. Am J Ophthalmol. 2006;142(1):82–7.CrossRefPubMed
24.
Judd RA, Digre KB, Warner JE, et al. Shedding light on Blepharospasm: a patient–researcher partnership approach to assessment of photophobia and impact on activities of daily living. Neuro-Ophthalmology. 2009;31(3):49–54.CrossRef
25.
Peckham EL, Lopez G, Shamim EA, et al. Clinical features of patients with Blepharospasm: a report of 240 cases. European journal of neurology the official journal of the European Federation of Neurological. For Soc. 2011;18(3):382.
26.
Herz NL, Yen MT. Modulation of sensory photophobia in essential blepharospasm with chromatic lenses. Ophthalmology. 2005;112(12):2208–11.CrossRefPubMed
27.
Nath U, Ben-Shlomo Y, Thomson RG, et al. Clinical features and natural history of progressive supranuclear palsy: a clinical cohort study. Neurology. 2003;60(6):910–6.CrossRefPubMed
28.
Cooper AD, Josephs KA. Photophobia, visual hallucinations, and REM sleep behavior disorder in progressive supranuclear palsy and corticobasal degeneration: a prospective study. Parkinsonism Relat Disord. 2009;15(1):59–61.CrossRefPubMed
29.
Sihlbom C, Van DHI, Lidell ME, et al. Current treatment options in neurology. Le J Médical Libanais the Lebanese Med J. 2004;52(52):33–8.
30.
Kapoor N, Ciuffreda KJ. Vision disturbances following traumatic brain injury. Curr Treat Options Neurol. 2002;4(4):271–80.CrossRefPubMed
31.
Vos PE, Battistin L, Birbamer G, et al. EFNS guideline on mild traumatic brain injury: report of an EFNS task force. Eur J Neurol. 2002;9(3):207–19.CrossRefPubMed
32.
Capo-Aponte JE, Urosevich TG, Temme LA, et al. Visual dysfunctions and symptoms during the subacute stage of blast-induced mild traumatic brain injury. Mil Med. 2012;177(7):804–13.CrossRefPubMed
33.
Truong JQ, Ciuffreda KJ, Han MH, et al. Photosensitivity in mild traumatic brain injury (mTBI): a retrospective analysis. Brain Inj. 2014;28(10):1283–7.CrossRefPubMed
34.
Ksendzovsky A, Pomeraniec IJ, Zaghloul KA, et al. Clinical implications of the melanopsin-based non-image-forming visual system. Neurology. 2017;88(13):1282–90.CrossRefPubMed
35.
36.
Berson DM, Dunn FA, Takao M. Phototransduction by retinal ganglion cells that set the circadian clock. Science. 2002;295(5557):1070–3.CrossRefPubMed
37.
Kawasaki A, Kardon RH. Intrinsically photosensitive retinal ganglion cells. J Neuroophthalmol. 2007;27(3):195–204.CrossRefPubMed
38.
39.
Matynia A, Parikh S, Chen B, et al. Intrinsically photosensitive retinal ganglion cells are the primary but not exclusive circuit for light aversion. Exp Eye Res. 2012;105:60–9.CrossRefPubMed
40.
41.
Kardon R. Melanopsin and its role in photophobia. Acta Ophthalmol. 2012;90(Supplement s249):0–0.
42.
Okamoto K, Thompson R, Tashiro A, et al. Bright light produces Fos-positive neurons in caudal trigeminal brainstem. Neuroscience. 2009;160(4):858–64.CrossRefPubMed
43.
Noseda R, Constandil L, Bourgeais L, et al. Changes of meningeal excitability mediated by corticotrigeminal networks: a link for the endogenous modulation of migraine pain. J Neurosci. 2010;30(43):14420–9.CrossRefPubMed
44.
Dolgonos S, Ayyala H, Evinger C. Light-induced trigeminal sensitization without central visual pathways: another mechanism for photophobia. Invest Ophthalmol Vis Sci. 2011;52(11):7852–8.CrossRefPubMedPubMedCentral
45.
46.
47.
Recober A, Kaiser EA, Kuburas A, et al. Induction of multiple photophobic behaviors in a transgenic mouse sensitized to CGRP. Neuropharmacology. 2010;58(1):156–65.CrossRefPubMed
48.
Evans RW, Seifert T, Kailasam J, et al. The use of questions to determine the presence of photophobia and phonophobia during migraine. Headache. 2008;48(3):395–7.CrossRefPubMed
49.
Bossini L. Sensibilità alla luce e psicopatologia: validazione del Questionario per la Valutazione della Fotosensibilità (QVF). Headache. 1988;28:124–34.CrossRef
50.
Choi JY. Oh K, Kim BJ, et al. usefulness of a photophobia questionnaire in patients with migraine. Cephalalgia. 2009;29(9):953–9.CrossRefPubMed
51.
52.
Edvinsson L, Villalon CM, MaassenVanDenBrink A. Basic mechanisms of migraine and its acute treatment. Pharmacol Ther. 2012;136(3):319–33.CrossRefPubMed
53.
Negro A, Lionetto L, Simmaco M, et al. CGRP receptor antagonists: an expanding drug class for acute migraine? Expert Opin Investig Drugs. 2012;21(6):807–18.CrossRefPubMed
54.
Yerry JA, Kuehn D, Finkel AG. Onabotulinum toxin a for the treatment of headache in service members with a history of mild traumatic brain injury: a cohort study. Headache. 2015;55(3):395–406.CrossRefPubMed
55.
Blackburn MK, Lamb RD, Digre KB, et al. FL-41 tint improves blink frequency, light sensitivity, and functional limitations in patients with benign essential blepharospasm. Ophthalmology. 2009;116(5):997–1001.CrossRefPubMedPubMedCentral
Metadata
Title
Photophobia in neurologic disorders
Authors
Yiwen Wu
Mark Hallett
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Translational Neurodegeneration / Issue 1/2017
Electronic ISSN: 2047-9158
DOI
https://doi.org/10.1186/s40035-017-0095-3

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