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01-12-2023 | Photodynamic Therapy | Original Article

Clinical efficacy of photodynamic therapy on halitosis: a systematic review and meta-analysis

Authors: Nini Wang, Siyuan Hao, Jinmei Zhang, Jingmei Yang

Published in: Lasers in Medical Science | Issue 1/2023

Abstract

Halitosis is a widespread health problem with complex factors, and therapeutic effects sometimes are unsatisfactory. Plenty of clinical trials have tried to prove the effectiveness of photodynamic therapy (PDT), but the results are indeterminate. This study aimed to evaluate the clinical efficacy of PDT on halitosis. We searched PubMed, Cochrane Library, Embase, Web of Science, and Scopus from inception to August 10, 2022, and only studies about the PDT on halitosis were included. The criteria for meta-analysis comprised randomized controlled trials (RCTs) comparing the treatment of PDT with tongue scraper (TS) immediately after the halitosis therapy and during a 7-, 14-, 30-, and 90-day follow-up. Eight eligible studies involving 345 patients were included in this study. It was shown that PDT (MD = − 34.49, 95% CI [− 66.34, − 2.64], P = 0.03) or PDT + TS (MD = − 67.72, 95% CI [− 101.17, − 34.28], P < 0.001) had better efficacy than TS on the H2S concentration reduction immediately after the halitosis therapy. No significant differences were observed in reducing the H2S among TS, PDT alone, and PDT + TS at the follow-up. Besides, no difference between PDT and TS was found in the reduction of CH3SCH3 and CH3SH. Based on the current evidence, PDT and PDT + TS demonstrate efficacy in the treatment of halitosis in the short term, and PDT was shown to be a beneficial and promising therapeutic method.

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Tonzetich J (1977) Production and origin of oral malodor: a review of mechanisms and methods of analysis. J Periodontol 48(1):13–20. https://doi.org/10.1902/jop.1977.48.1.13CrossRefPubMed

Mogilnicka I, Bogucki P, Ufnal M (2020) Microbiota and malodor-etiology and management. Int J Mol Sci 21(8):2886. https://doi.org/10.3390/ijms21082886CrossRefPubMedPubMedCentral

Chen X, Zhang Y, Lu HX, Feng XP (2016) Factors associated with halitosis in white-collar employees in Shanghai, China. PLoS One 11(5):e0155592. https://doi.org/10.1371/journal.pone.0155592CrossRefPubMedPubMedCentral

Elias MS, Ferriani M (2006) Historical and social aspects of halitosis. Rev Lat Am Enfermagem 14(5):821–823. https://doi.org/10.1590/s0104-11692006000500026CrossRefPubMed

Schertel Cassiano L, Abdullahi F, Leite FRM, López R, Peres MA, Nascimento GG (2021) The association between halitosis and oral-health-related quality of life: a systematic review and meta-analysis. J Clin Periodontol 48(11):1458–1469. https://doi.org/10.1111/jcpe.13530CrossRefPubMed

Krespi YP, Shrime MG, Kacker A (2006) The relationship between oral malodor and volatile sulfur compound-producing bacteria. Otolaryngol Head Neck Surg 135(5):671–676. https://doi.org/10.1016/j.otohns.2005.09.036CrossRefPubMed

Casu C, Nosotti MG (2021) Photodynamic therapy for halitosis: could be possible? Biointerface Res Appl Chem 11(1):7493–7500. https://doi.org/10.33263/briac111.74937500CrossRef

Tolentino Ede S, Chinellato LE, Tarzia O (2011) Saliva and tongue coating pH before and after use of mouthwashes and relationship with parameters of halitosis. J Appl Oral Sci 19(2):90–94. https://doi.org/10.1590/s1678-77572011000200002CrossRefPubMed

Ye W, Zhang Y, He M, Zhu C, Feng XP (2019) Relationship of tongue coating microbiome on volatile sulfur compounds in healthy and halitosis adults. J Breath Res 14(1):016005. https://doi.org/10.1088/1752-7163/ab47b4CrossRefPubMed

10.

Motta PB, Motta LJ, Campos TM, Goncalves MLL, Santos EM, Martimbianco ALC, de Andrade DJC, Mesquita-Ferrari RA, Fernandes KPS, Horliana A, Bussadori SK (2022) Effect of photodynamic therapy on halitosis: a systematic review of randomized controlled trials. Sensors (Basel) 22(2):469. https://doi.org/10.3390/s22020469CrossRefPubMed

11.

Jones CG (2000) (1997) Chlorhexidine: is it still the gold standard? Periodontol 15:55–62. https://doi.org/10.1111/j.1600-0757.1997.tb00105.xCrossRef

12.

Liu PF, Zhu WH, Huang CM (2009) Vaccines and photodynamic therapies for oral microbial-related diseases. Curr Drug Metab 10(1):90–94. https://doi.org/10.2174/138920009787048365CrossRefPubMedPubMedCentral

13.

Choi HN, Cho YS, Koo JW (2021) The effect of mechanical tongue cleaning on oral malodor and tongue coating. Int J Environ Res Public Health 19(1):108. https://doi.org/10.3390/ijerph19010108CrossRefPubMedPubMedCentral

14.

Quirynen M, Avontroodt P, Soers C, Zhao H, Pauwels M, van Steenberghe D (2004) Impact of tongue cleansers on microbial load and taste. J Clin Periodontol 31(7):506–510. https://doi.org/10.1111/j.0303-6979.2004.00507.xCrossRefPubMed

15.

Collins LM, Dawes C (1987) The surface area of the adult human mouth and thickness of the salivary film covering the teeth and oral mucosa. J Dent Res 66(8):1300–1302. https://doi.org/10.1177/00220345870660080201CrossRefPubMed

16.

Hope CK, Wilson M (2006) Induction of lethal photosensitization in biofilms using a confocal scanning laser as the excitation source. J Antimicrob Chemother 57(6):1227–1230. https://doi.org/10.1093/jac/dkl096CrossRefPubMed

17.

Wilson M (2004) Lethal photosensitisation of oral bacteria and its potential application in the photodynamic therapy of oral infections. Photochem Photobiol Sci 3(5):412–418. https://doi.org/10.1039/b211266cCrossRefPubMed

18.

Seemann R, Conceicao MD, Filippi A, Greenman J, Lenton P, Nachnani S, Quirynen M, Roldan S, Schulze H, Sterer N, Tangerman A, Winkel EG, Yaegaki K, Rosenberg M (2014) Halitosis management by the general dental practitioner–results of an international consensus workshop. J Breath Res 8(1):017101. https://doi.org/10.1088/1752-7155/8/1/017101CrossRefPubMed

19.

Prażmo EJ, Kwaśny M, Łapiński M, Mielczarek A (2016) Photodynamic therapy as a promising method used in the treatment of oral diseases. Adv Clin Exp Med 25(4):799–807. https://doi.org/10.17219/acem/32488CrossRefPubMed

20.

Soukos NS (2000) Goodson J M (2011) Photodynamic therapy in the control of oral biofilms. Periodontol 55(1):143–166. https://doi.org/10.1111/j.1600-0757.2010.00346.xCrossRef

21.

Kellesarian SV, Malignaggi VR, Al-Kheraif AA, Al-Askar M, Yunker M, Javed F (2017) Effect of antimicrobial photodynamic therapy and laser alone as adjunct to mechanical debridement in the management of halitosis: a systematic review. Quintessence Int 48(7):575–583. https://doi.org/10.3290/j.qi.a38264CrossRefPubMed

22.

Costa da Mota AC, Franca CM, Prates R, Deana AM, Costa Santos L, Lopes Garcia R, Leal Goncalves ML, Mesquita Ferrari RA, Porta Santos Fernandes K, Kalil Bussadori S (2016) Effect of photodynamic therapy for the treatment of halitosis in adolescents-a controlled, microbiological, clinical trial. J Biophotonics 9(11–12):1337–1343. https://doi.org/10.1002/jbio.201600067CrossRefPubMed

23.

Llanos do Vale K, RattoTempestiniHorliana AC, Romero Dos Santos S, Oppido Schalch T, Melo de Ana A, AgnelliMesquita Ferrari R, KalilBussadori S, Porta Santos Fernandes K (2021) Treatment of halitosis with photodynamic therapy in older adults with complete dentures: a randomized, controlled, clinical trial. Photodiagnosis Photodyn Ther 33:102128. https://doi.org/10.1016/j.pdpdt.2020.102128CrossRefPubMed

24.

da Mota ACC, Goncalves MLL, Horliana A, Deana AM, de Souza CLA, Gomes AO, Mayer MPA, Suguimoto ESA, Fernandes KPS, Mesquita-Ferrari RA, Prates RA, Motta LJ, Bussadori SK (2021) Effect of antimicrobial photodynamic therapy with red led and methylene blue on the reduction of halitosis: controlled microbiological clinical trial. Lasers Med Sci 37(2):877–886. https://doi.org/10.1007/s10103-021-03325-xCrossRefPubMed

25.

Goncalves MLL, da Mota ACC, Deana AM, Cavalcante LAS, Horliana A, Pavani C, Motta LJ, Fernandes KPS, Mesquita-Ferrari RA, da Silva DFT, Motta PB, Araujo Prates R, Bussadori SK (2020) Antimicrobial photodynamic therapy with Bixa orellana extract and blue LED in the reduction of halitosis-A randomized, controlled clinical trial. Photodiagnosis Photodyn Ther 30:101751. https://doi.org/10.1016/j.pdpdt.2020.101751CrossRefPubMed

26.

Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D (2009) The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med 151(4):W65-94. https://doi.org/10.7326/0003-4819-151-4-200908180-00136CrossRefPubMed

27.

Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Bmj 327(7414):557–560. https://doi.org/10.1136/bmj.327.7414.557CrossRefPubMedPubMedCentral

28.

Parmar MK, Torri V, Stewart L (1998) Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 17(24):2815–2834. https://doi.org/10.1002/(sici)1097-0258(19981230)17:24%3c2815::aid-sim110%3e3.0.co;2-8CrossRefPubMed

29.

Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27(6):1785–1805. https://doi.org/10.1177/0962280216669183CrossRefPubMed

30.

Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol 14:135. https://doi.org/10.1186/1471-2288-14-135CrossRefPubMedPubMedCentral

31.

Alshahrani AA, Alhaizaey A, Kamran MA, Alshahrani I (2020) Efficacy of antimicrobial photodynamic therapy against halitosis in adolescent patients undergoing orthodontic treatment. Photodiagnosis Photodyn Ther 32:102019. https://doi.org/10.1016/j.pdpdt.2020.102019CrossRefPubMed

32.

Labban N, Assery MK, Al-Kattan R, Al-Shibani N, Alfouzan AF, Al Taweel SM (2020) Antimicrobial capacity of photodynamic therapy on oral health-related quality of life and halitosis among elderly patients wearing removal dentures. Photodiagnosis Photodyn Ther 32:102059. https://doi.org/10.1016/j.pdpdt.2020.102059CrossRefPubMed

33.

Lopes RG, da Mota AC, Soares C, Tarzia O, Deana AM, Prates RA, Franca CM, Fernandes KP, Ferrari RA, Bussadori SK (2016) Immediate results of photodynamic therapy for the treatment of halitosis in adolescents: a randomized, controlled, clinical trial. Lasers Med Sci 31(1):41–47. https://doi.org/10.1007/s10103-015-1822-6CrossRefPubMed

34.

Romero SS, do Vale KL, Remolina VG, Silva TG, Schalch TO, Ramalho KM, Negreiros RM, Ando ES, Mayer MPA, Mesquita Ferrari RA, Motta LJ, Fernandes KPS, Bussadori SK, Horliana A (2021) Oral hygiene associated with antimicrobial photodynamic therapy or lingual scraper in the reduction of halitosis after 90 days follow up: a randomized, controlled, single-blinded trial. Photodiagnosis Photodyn Ther 33:102057. https://doi.org/10.1016/j.pdpdt.2020.102057CrossRefPubMed

35.

Al Deeb M, Alresayes S, Mokeem SA, Alhenaki AM, AlHelal A, Shafqat SS, Vohra F, Abduljabbar T (2020) Clinical and immunological peri-implant parameters among cigarette and electronic smoking patients treated with photochemotherapy: a randomized controlled clinical trial. Photodiagnosis Photodyn Ther 31:101800. https://doi.org/10.1016/j.pdpdt.2020.101800CrossRefPubMed

36.

Stephen AS, Dhadwal N, Nagala V, Gonzales-Marin C, Gillam DG, Bradshaw DJ, Burnett GR, Allaker RP (2021) Interdental and subgingival microbiota may affect the tongue microbial ecology and oral malodour in health, gingivitis and periodontitis. J Periodontal Res 56(6):1174–1184. https://doi.org/10.1111/jre.12931CrossRefPubMed

37.

Porter SR, Scully C (2006) Oral malodour (halitosis). Br Med J 333(7569):632–635. https://doi.org/10.1136/bmj.38954.631968.AECrossRef

38.

Lopes RG, de Santi ME, Franco BE, Deana AM, Prates RA, França CM, Fernandes KP, Ferrari RA, Bussadori SK (2014) Photodynamic therapy as novel treatment for halitosis in adolescents: a case series study. J Lasers Med Sci 5(3):146–152PubMedPubMedCentral

39.

Jori G, Fabris C, Soncin M, Ferro S, Coppellotti O, Dei D, Fantetti L, Chiti G, Roncucci G (2006) Photodynamic therapy in the treatment of microbial infections: basic principles and perspective applications. Lasers Surg Med 38(5):468–481. https://doi.org/10.1002/lsm.20361CrossRefPubMed

40.

Mongardini C, Di Tanna GL, Pilloni A (2014) Light-activated disinfection using a light-emitting diode lamp in the red spectrum: clinical and microbiological short-term findings on periodontitis patients in maintenance. A randomized controlled split-mouth clinical trial. Lasers Med Sci 29(1):1–8. https://doi.org/10.1007/s10103-012-1225-xCrossRefPubMed

41.

Rohrbach DJ, Rigual N, Tracy E, Kowalczewski A, Keymel KL, Cooper MT, Mo W, Baumann H, Henderson BW, Sunar U (2012) Interlesion differences in the local photodynamic therapy response of oral cavity lesions assessed by diffuse optical spectroscopies. Biomed Opt Express 3(9):2142–2153. https://doi.org/10.1364/boe.3.002142CrossRefPubMedPubMedCentral

42.

Zhao R, Huang R, Long H, Li Y, Gao M, Lai W (2020) The dynamics of the oral microbiome and oral health among patients receiving clear aligner orthodontic treatment. Oral Dis 26(2):473–483. https://doi.org/10.1111/odi.13175CrossRefPubMed

43.

Mantzourani M, Gilbert SC, Fenlon M, Beighton D (2010) Non-oral bifidobacteria and the aciduric microbiota of the denture plaque biofilm. Mol Oral Microbiol 25(3):190–199. https://doi.org/10.1111/j.2041-1014.2009.00565.xCrossRefPubMed

44.

Lucchese A, Nocini R, Lo Giudice A, Asperio P, Guglietta F, Carenzi L, Bertacci A, Donadello D, Farronato M, Maspero C, Zerman N (2022) Oral and throat microbiological changes after orthodontic debonding. New Microbiol 45(4):278–283PubMed

45.

Li M, Wang S, Li R, Wang Y, Fan X, Gong W, Ma Y (2022) The mechanical and antibacterial properties of boron nitride/silver nanocomposite enhanced polymethyl methacrylate resin for application in oral denture bases. Biomimetics (Basel) 7(3):138. https://doi.org/10.3390/biomimetics7030138CrossRefPubMed

Title: Clinical efficacy of photodynamic therapy on halitosis: a systematic review and meta-analysis
Authors: Nini Wang
Siyuan Hao
Jinmei Zhang
Jingmei Yang
Publication date: 01-12-2023
Publisher: Springer London
Keywords: Photodynamic Therapy
Halitosis
Halitosis
Published in: Lasers in Medical Science / Issue 1/2023
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-022-03700-2

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Clinical efficacy of photodynamic therapy on halitosis: a systematic review and meta-analysis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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