Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
International Ophthalmology
Published in: International Ophthalmology 1/2024

01-12-2024 | Photodynamic Therapy | Review

Applications of photodynamic therapy in keratitis

Authors: Ayaz Anwar, Naveed Ahmed Khan, Ahmad M. Alharbi, Ayman Alhazmi, Ruqaiyyah Siddiqui

Published in: International Ophthalmology | Issue 1/2024

Login to get access

Abstract

Keratitis is corneal inflammatory disease which may be caused by several reason such as an injury, allergy, as well as a microbial infection. Besides these, overexposure to ultraviolet light and unhygienic practice of contact lenses are also associated with keratitis. Based on the cause of keratitis, different lines of treatments are recommended. Photodynamic therapy is a promising approach that utilizes light activated compounds to instigate either killing or healing mechanism to treat various diseases including both communicable and non-communicable diseases. This review focuses on clinically-important patent applications and the recent literature for the use of photodynamic therapy against keratitis.
Literature
1.
Cope JR, Collier SA, Rao MM, Chalmers R, Mitchell GL, Richdale K, Wagner H, Kinoshita BT, Lam DY, Sorbara L, Zimmerman A (2015) Contact lens wearer demographics and risk behaviors for contact lens-related eye infections—United States, 2014. Morb Mortal Wkly Rep 64(32):865CrossRef
2.
Keay L, Edwards K, Stapleton F (2009) Signs, symptoms, and comorbidities in contact lens-related microbial keratitis. Optom Vis Sci 86(7):803–809CrossRefPubMed
3.
Singh P, Gupta A, Tripathy K (2022) Keratitis. StatPearls Publishing, St. Petersburg
4.
Lakhundi S, Siddiqui R, Khan NA (2017) Pathogenesis of microbial keratitis. Microb Pathog 104:97–109CrossRefPubMed
5.
Randag AC, de Kroon L, Otten H, Arias Claro-Handgraaf C, Schimmer B, Kortbeek T, van Rooij J, Stelma FF (2023) In vitro effectiveness of soft contact lens solutions available on the Dutch market against Acanthamoeba species. Pathogens 12(2):214CrossRefPubMedPubMedCentral
6.
Siddiqui R, Lakhundi S, Khan NA (2015) Status of the effectiveness of contact lens solutions against keratitis-causing pathogens. Cont Lens Anterior Eye 38(1):34–38CrossRefPubMed
7.
Tjia KF, van Putten JP, Pels E, Zanen HC (1988) The interaction between Neisseria gonorrhoeae and the human cornea in organ culture. An electron microscopic study. Graefes Arch Clin Exp Ophthalmol 226(4):341–345CrossRefPubMed
8.
9.
Chatterjee S, Agrawal D (2016) Multi-drug resistant Pseudomonas aeruginosa keratitis and its effective treatment with topical colistimethate. Ind J Ophthalmol 64(2):153–157CrossRef
10.
Didier ES, Maddry JA, Brindley PJ, Stovall ME, Didier PJ (2005) Therapeutic strategies for human microsporidia infections. Expert Rev Anti Infect Ther 3(3):419–434CrossRefPubMed
11.
Wilhelmus KR (2015) Antiviral treatment and other therapeutic interventions for herpes simplex virus epithelial keratitis. Cochrane Database Syst Rev 1:CD002898PubMed
12.
Khan NA, Anwar A, Siddiqui R (2019) Acanthamoeba keratitis: current status and urgent research priorities. Curr Med Chem 26(30):5711–5726CrossRefPubMed
13.
Green MD, Apel AJ, Naduvilath T, Stapleton FJ (2007) Clinical outcomes of keratitis. Clin Exp Ophthalmol 35(5):421–426CrossRefPubMed
14.
Austin A, Lietman T, Rose-Nussbaumer J (2017) Update on the management of infectious keratitis. Ophthalmology 124(11):1678–1689CrossRefPubMed
15.
Tuft S, Somerville TF, Li JPO, Neal T, De S, Horsburgh MJ, Fothergill JL, Foulkes D, Kaye S (2022) Bacterial keratitis: identifying the areas of clinical uncertainty. Prog Retin Eye Res 89:101031CrossRefPubMed
16.
17.
Dolmans DE, Fukumura D, Jain RK (2003) Photodynamic therapy for cancer. Nat Rev Cancer 3(5):380–387CrossRefPubMed
18.
Correia JH, Rodrigues JA, Pimenta S, Dong T, Yang Z (2021) Photodynamic therapy review: principles, photosensitizers, applications, and future directions. Pharmaceutics 13(9):1332CrossRefPubMedPubMedCentral
19.
20.
Nwogu C, Kloc A, Attwood K, Bshara W, Durrani F, Pandey R (2021) Porfimer sodium versus PS785 for photodynamic therapy (PDT) of lung cancer xenografts in mice. J Surg Res 263:245–250CrossRefPubMed
21.
Kim M, Jung HY, Park HJ (2015) Topical PDT in the treatment of benign skin diseases: principles and new applications. Int J Mol Sci 16(10):23259–23278CrossRefPubMedPubMedCentral
22.
Pariser DM, Lowe NJ, Stewart DM, Jarratt MT, Lucky AW, Pariser RJ, Yamauchi PS (2003) Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: results of a prospective randomized multicenter trial. J Am Acad Dermatol 48(2):227–232CrossRefPubMed
23.
Akram Z, Al-Shareef SA, Daood U, Asiri FY, Shah AH, AlQahtani MA, Vohra F, Javed F (2016) Bactericidal efficacy of photodynamic therapy against periodontal pathogens in periodontal disease: a systematic review. Photomed Laser Surg 34(4):137–149CrossRefPubMed
24.
Hung JH, Lee CN, Hsu HW, Ng IS, Wu CJ, Yu CK, Lee NY, Chang Y, Wong TW (2021) Recent advances in photodynamic therapy against fungal keratitis. Pharmaceutics 13(12):2011CrossRefPubMedPubMedCentral
25.
de Paiva AD, da Costa Ferreira M, da Fonseca AD (2022) Photodynamic therapy for treatment of bacterial keratitis. Photodiagnosis Photodyn Ther 37:102717CrossRefPubMed
26.
Szentmáry N, Goebels S, Bischoff M, Seitz B (2012) Photodynamic therapy for infectious keratitis. Ophthalmologe 109:165–170CrossRefPubMed
27.
Han H, Gao Y, Chai M, Zhang X, Liu S, Huang Y, Jin Q, Grzybowski A, Ji J, Yao K (2020) Biofilm microenvironment activated supramolecular nanoparticles for enhanced photodynamic therapy of bacterial keratitis. J Control Rel 327:676–687CrossRef
28.
Bai Y, Hu Y, Gao Y, Wei X, Li J, Zhang Y, Wu Z, Zhang X (2021) Oxygen self-supplying nanotherapeutic for mitigation of tissue hypoxia and enhanced photodynamic therapy of bacterial keratitis. ACS Appl Mater Interfaces 13(29):33790–33801CrossRefPubMed
29.
Su G, Wei Z, Wang L, Shen J, Baudouin C, Labbé A, Liang Q (2020) Evaluation of toluidine blue-mediated photodynamic therapy for experimental bacterial keratitis in rabbits. Transl Vision Sci Technol 9(3):13CrossRef
30.
Arboleda A, Miller D, Cabot F, Taneja M, Aguilar MC, Alawa K, Amescua G, Yoo SH, Parel JM (2014) Assessment of rose bengal versus riboflavin photodynamic therapy for inhibition of fungal keratitis isolates. Amer J Ophthalmol 158(1):64–70CrossRefPubMed
31.
Shih MH, Huang FC (2011) Effects of photodynamic therapy on rapidly growing nontuberculous mycobacteria keratitis. Invest Ophthalmol Vis Sci 52(1):223–229CrossRefPubMed
32.
Aqeel Y, Siddiqui R, Anwar A, Shah MR, Khoja S, Khan NA (2015) Photochemotherapeutic strategy against Acanthamoeba infections. Antimicrob Agents Chemother 59(6):3031–3041CrossRefPubMedPubMedCentral
33.
Imran M, Muazzam AG, Habib A, Matin A (2016) Synthesis, characterization and amoebicidal potential of locally synthesized TiO2 nanoparticles against pathogenic Acanthamoeba trophozoites in vitro. J Photochem Photobiol B Biol 159:125–132CrossRef
34.
Gomart G, Denis J, Bourcier T, Dory A, Abou-Bacar A, Candolfi E, Sauer A (2018) In vitro amoebicidal activity of titanium dioxide/UV-A combination against Acanthamoeba. Invest Ophthalmol Vis Sci 59(11):4567–4571CrossRefPubMed
35.
Dwia Pertiwi Y, Chikama T, Sueoka K, Ko JA, Kiuchi Y, Onodera M, Sakaguchi T (2021) Efficacy of photodynamic anti-microbial chemotherapy for Acanthamoeba keratitis in vivo. Lasers Surg Med 53(5):695–702CrossRefPubMed
36.
Pertiwi YD, Chikama T, Sueoka K, Ko JA, Kiuchi Y, Onodera M, Sakaguchi T (2019) Antimicrobial photodynamic therapy with the photosensitizer TONS504 eradicates Acanthamoeba. Photodiagnosis Photodyn Ther 28:166–171CrossRefPubMed
37.
Atalay HT, Uysal BS, Sarzhanov F, Usluca S, Yeşilırmak N, Özmen MC, Erganiş S, Tefon AB, Dogruman-Al F, Bilgihan K (2020) Rose Bengal-mediated photodynamic antimicrobial treatment of Acanthamoeba keratitis. Curr Eye Res 45(10):1205–1210CrossRefPubMed
38.
Chen Z, Xuguang S, Zhiqun W, Ran L (2008) In vitro amoebacidal activity of photodynamic therapy on Acanthamoeba. Brit J Ophthalmol 92(9):1283–1286CrossRef
39.
Mito T, Suzuki T, Kobayashi T, Zheng X, Hayashi Y, Shiraishi A, Ohashi Y (2012) Effect of photodynamic therapy with methylene blue on Acanthamoeba in vitro. Invest Ophthalmol Vis Sci 53(10):6305–6313CrossRefPubMed
40.
Korea Institute of Science and Technology: KR20220158663A (2022).
41.
42.
Hangzhou Dac Biotech Co Ltd: AU2022206809A1 (2022).
43.
Aldeyra Therapeutics, Inc.: WO2023278816A1 (2023).
44.
Wenzhou Medical University: CN114907573A (2022).
45.
Eye and ENT Hospital of Fudan University: CN115054432A (2022).
46.
Wenzhou Medical University: CN114942530A (2022).
47.
Wenzhou Medical University: CN114588524A (2022).
48.
Allysta Pharmaceuticals Inc.: US20220331393A1 (2022).
49.
Desmond Christopher Adler, Jason Hill, David Usher, Mikhail Smirnov, Ahalya Viswanathan: US20220193439A1 (2021).
50.
51.
52.
Nisshang Santen Pharmaceutical Co., Ltd., Nisshang Phibotek Medical Equipment Co., Ltd.: TW202216153A (2022).
53.
Korea Advanced Institute of Science and Technology KAIST: US20210393723A1 (2021).
54.
University Of Miami: WO2021237131A1 (2021).
55.
University Of Miami: WO2021202398A1 (2021).
56.
Wenzhou Research Institute Of Chinese Academy Of Sciences, Wenzhou Institute Of Biomaterials And Engineering: CN113041348A (2021).
57.
58.
59.
60.
Universidade De São Paulo – Usp: BR102020025170A2 (2021).
61.
62.
Vision Engineering Italy Srl: WO2021009623A1 (2020).
63.
The University of Massachusetts, The General Hospital Corporation: WO2020251933A1 (2020).
64.
Harbin Normal University: CN111467490A (2020).
65.
Korea Institute of Science and Technology: KR20210093608A (2022).
66.
University of California, US Department of Veterans Affairs VA: JP2022503941A (2022)
67.
California Institute Of Technology: WO2020061079A1 (2020)
68.
Seoul Viosys Co., Ltd.: WO2019209063A1 (2019)
69.
Aleyegn Technologies LLC: US20200000638A1 (2020)
70.
Metadata
Title
Applications of photodynamic therapy in keratitis
Authors
Ayaz Anwar
Naveed Ahmed Khan
Ahmad M. Alharbi
Ayman Alhazmi
Ruqaiyyah Siddiqui
Publication date
01-12-2024
Publisher
Springer Netherlands
Published in
International Ophthalmology / Issue 1/2024
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI
https://doi.org/10.1007/s10792-024-03062-4

Other articles of this Issue 1/2024

International Ophthalmology 1/2024 Go to the issue

Original Paper

Ocular injuries associated with motor vehicle accidents: long term effects on quality of life

Original Paper

Glaucoma progression due to refraining examination amid the pandemic of COVID-19

Original Paper

Objective demonstration of eyelid spasm relief with smartphone and custom software in hemifacial spasm patients

Original Paper

Observation on the tilt and decentration of multifocal intraocular lens with optic capture in Berger space for pediatric cataract

Original Paper

Corneal endothelial changes seven years after phacoemulsification cataract surgery

Original Paper

Cataract surgery with new monofocal intraocular lens enhanced for intermediate vision and standard monofocal intraocular lens for retinal disorder