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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2004

01-08-2004 | Commentary

Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal

Author: Marina Botto

Published in: Arthritis Research & Therapy | Issue 4/2004

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Abstract

Apoptosis, a physiological process of controlled cell death, is essential during embryonic development and for the maintenance of tissue homeostasis. In recent years the view has emerged that dying cells can provide specific signals that enable recruitment and recognition by phagocytes. Exposure of phosphatidylserine, the best characterized of such signals, allows safe clearance of apoptotic waste without induction of inflammation. Here I re-examine some of the arguments that underpin the importance of these clearance mechanisms in light of recent observations from an animal model that lacks the receptor specific for phosphatidylserine.
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Metadata
Title
Phosphatidylserine receptor and apoptosis: consequences of a non-ingested meal
Author
Marina Botto
Publication date
01-08-2004
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2004
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1191

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