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Journal of Cancer Research and Clinical Oncology

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Open Access 01-08-2017 | Review – Cancer Research

Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics

Authors: Hirota Fujiki, Maitree Suttajit, Anchalee Rawangkan, Keisuke Iida, Pornngarm Limtrakul, Sonthaya Umsumarng, Masami Suganuma

Published in: Journal of Cancer Research and Clinical Oncology | Issue 8/2017

Abstract

Purpose

In 1988, we first reported the complete chemical structure of a new type of phorbol ester, abbreviated to DHPB, found in seed oil of Jatropha curcas L. (Saboodam in Thai) and its tumor-promoting activity on mouse skin. Although this seed oil contains toxic phorbol ester, it was planned to use it as a feasible renewable oil and the extracted seed cake as fertilizer. This utilization value opened a new science of Jatropha curcas.

Methods

The main experimental results are cited from our publications, and the relevant literature screened from journals and PubMed.

Results and discussion

This paper begins with our original work on the structural elucidation of a new phorbol ester, 12-deoxy-16-hydroxyphorbol (DHPB): its tumor-promoting activity was compared with that of TPA. We think that it is timely to review the following research advances with Jatropha curcas, so numerous topics are classified as follows: (1) historical development of phorbol esters in seed oil; (2) toxicity of phorbol ester based on various bioassays; (3) degradation of phorbol ester; (4) a new pharmaceutical compound in seed; and (5) tumor promotion and progression with endogeneous tumor promoters in human carcinogenesis. The discovery of phorbol ester in seed oil raised awareness of the danger of public use of seed oil and seed cake in Thailand, and also indicated the necessity of discussing the concept of primary and tertiary cancer preventions.

Conclusion

It is worthwhile to study the future benefits and cancer risks of globally distributed Jatropha curcas L.

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Title: Phorbol esters in seed oil of Jatropha curcas L. (saboodam in Thai) and their association with cancer prevention: from the initial investigation to the present topics
Authors: Hirota Fujiki
Maitree Suttajit
Anchalee Rawangkan
Keisuke Iida
Pornngarm Limtrakul
Sonthaya Umsumarng
Masami Suganuma
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Journal of Cancer Research and Clinical Oncology / Issue 8/2017
Print ISSN: 0171-5216
Electronic ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-017-2341-6

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