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01-11-2012 | Original Article

Phase II study of irinotecan and cisplatin with concurrent split-course radiotherapy in limited-disease small cell lung cancer

Authors: Minoru Fukuda, Yoichi Nakamura, Akitoshi Kinoshita, Yoshifumi Soejima, Hiroyuki Yamaguchi, Takaya Ikeda, Koichi Izumikawa, Hiroshi Takatani, Masaaki Fukuda, Hiroshi Soda, Nobuyuki Hayashi, Kazuhiro Tsukamoto, Mikio Oka, Shigeru Kohno

Published in: Cancer Chemotherapy and Pharmacology | Issue 5/2012

Abstract

Background

Irinotecan and cisplatin are one of active regimens for patients with extensive-stage small cell lung cancer (SCLC). To determine the efficacy and toxicity of irinotecan and cisplatin with concurrent split-course thoracic radiotherapy in limited-disease (LD) SCLC, we conducted a phase II study.

Patients and methods

Thirty-four patients fulfilling the following eligibility criteria were enrolled: chemotherapy-naïve, good performance status (PS 0–1), age ≤75, LD-SCLC, and adequate organ function. The patients received irinotecan 40 mg/m² i.v. on days 1, 8, and 15, and cisplatin 60 mg/m² i.v. on day 1. Four cycles of chemotherapy were repeated every 4 weeks. Split-course thoracic radiotherapy of once-daily 2 Gy/day commenced on day 2 of each chemotherapy cycle, with 26 and 24 Gy administered in the first and second cycles, respectively.

Results

Thirty-four patients were eligible and assessable for response, toxicity, and survival. Patients’ characteristics were as follows: male/female = 29/5; PS 0/1 = 18/16; median age (range) = 67 (50–73); and stage IB/IIA/IIB/IIIA/IIIB = 2/2/3/16/11. The overall response was 100 % (CR 8, PR 26). Grade 4 leukopenia, neutropenia, grade 3–5 pneumonitis, diarrhea, and esophagitis occurred in 24, 38, 6, 3, and 0 %, respectively. There were 2 treatment-related deaths from pneumonitis. The median time to tumor progression was 14.3 months. The median overall survival time and the 2- and 5-year survival rates were 44.5 months, 66.7 and 46.1 %, respectively. No tumor progression was observed in patients with CR.

Conclusion

Irinotecan plus cisplatin with concurrent split-course thoracic radiotherapy was effective and tolerable in untreated LD-SCLC.

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Title: Phase II study of irinotecan and cisplatin with concurrent split-course radiotherapy in limited-disease small cell lung cancer
Authors: Minoru Fukuda
Yoichi Nakamura
Akitoshi Kinoshita
Yoshifumi Soejima
Hiroyuki Yamaguchi
Takaya Ikeda
Koichi Izumikawa
Hiroshi Takatani
Masaaki Fukuda
Hiroshi Soda
Nobuyuki Hayashi
Kazuhiro Tsukamoto
Mikio Oka
Shigeru Kohno
Publication date: 01-11-2012
Publisher: Springer-Verlag
Published in: Cancer Chemotherapy and Pharmacology / Issue 5/2012
Print ISSN: 0344-5704
Electronic ISSN: 1432-0843
DOI: https://doi.org/10.1007/s00280-012-1952-5

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Abstract

Background

Patients and methods

Results

Conclusion

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