Skip to main content
Top
Published in: Italian Journal of Pediatrics 1/2023

Open Access 01-12-2023 | Pharyngitis | Research

Nationwide survey on the management of pediatric pharyngitis in Italian emergency units

Authors: Gregorio P. Milani, Claudio Rosa, Naz Tuzger, Ilaria Alberti, Chiara Ghizzi, Stefania Zampogna, Angela Amigoni, Carlo Agostoni, Diego Peroni, Paola Marchisio, Elena Chiappini, IPSE study group

Published in: Italian Journal of Pediatrics | Issue 1/2023

Login to get access

Abstract

Background

Acute pharyngitis is a frequent reason for primary care or emergency unit visits in children. Most available data on pharyngitis management come from primary care studies that demonstrate an underuse of microbiological tests, a tendency to over-prescribe antibiotics and a risk of antimicrobial resistance increase. However, a comprehensive understanding of acute pharyngitis management in emergency units is lacking. This study aimed to investigate the frequency of rapid antigen test use to diagnose acute pharyngitis, as well as other diagnostic approaches, the therapeutic attitude, and follow-up of children with this condition in the emergency units.

Methods

A multicentric national study was conducted in Italian emergency departments between April and June 2022.

Results

A total of 107 out of 131 invited units (response rate 82%), participated in the survey. The results showed that half of the units use a scoring system to diagnose pharyngitis, with the McIsaac score being the most commonly used. Most emergency units (56%) were not provided with a rapid antigen diagnostic test by their hospital, but the test was more frequently available in units visiting more than 10,000 children yearly (57% vs 33%, respectively, p = 0.02). Almost half (47%) of the units prescribe antibiotics in children with pharyngitis despite the lack of microbiologically confirmed cases of Group A β-hemolytic streptococcus. Finally, about 25% of units prescribe amoxicillin-clavulanic acid to treat Group A β-hemolytic streptococcus pharyngitis.

Conclusions

The study sheds light on the approach to pharyngitis in emergency units, providing valuable information to improve the appropriate management of acute pharyngitis in this setting. The routinary provision of rapid antigen tests in the hospitals could enhance the diagnostic and therapeutic approach to pharyngitis.
Appendix
Available only for authorised users
Literature
1.
go back to reference Dooling KL, Shapiro DJ, Van Beneden C, Hersh AL, Hicks LA. Overprescribing and inappropriate antibiotic selection for children with pharyngitis in the United States, 1997–2010. JAMA Pediatr. 2014;168(11):1073–4.CrossRefPubMed Dooling KL, Shapiro DJ, Van Beneden C, Hersh AL, Hicks LA. Overprescribing and inappropriate antibiotic selection for children with pharyngitis in the United States, 1997–2010. JAMA Pediatr. 2014;168(11):1073–4.CrossRefPubMed
3.
go back to reference Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010;126(3):e557-564.CrossRefPubMed Shaikh N, Leonard E, Martin JM. Prevalence of streptococcal pharyngitis and streptococcal carriage in children: a meta-analysis. Pediatrics. 2010;126(3):e557-564.CrossRefPubMed
4.
go back to reference Chiappini E, Principi N, Mansi N, Serra A, De Masi S, Camaioni A, Esposito S, Felisati G, Galli L, Landi M, et al. Management of acute pharyngitis in children: summary of the Italian National Institute of Health guidelines. Clin Ther. 2012;34(6):1442-1458.e1442.CrossRefPubMed Chiappini E, Principi N, Mansi N, Serra A, De Masi S, Camaioni A, Esposito S, Felisati G, Galli L, Landi M, et al. Management of acute pharyngitis in children: summary of the Italian National Institute of Health guidelines. Clin Ther. 2012;34(6):1442-1458.e1442.CrossRefPubMed
5.
go back to reference Mustafa Z, Ghaffari M. Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review. Front Cell Infect Microbiol. 2020;10: 563627.CrossRefPubMedPubMedCentral Mustafa Z, Ghaffari M. Diagnostic Methods, Clinical Guidelines, and Antibiotic Treatment for Group A Streptococcal Pharyngitis: A Narrative Review. Front Cell Infect Microbiol. 2020;10: 563627.CrossRefPubMedPubMedCentral
6.
go back to reference Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM Jr, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, et al. Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010–2011. JAMA. 2016;315(17):1864–73.CrossRefPubMed Fleming-Dutra KE, Hersh AL, Shapiro DJ, Bartoces M, Enns EA, File TM Jr, Finkelstein JA, Gerber JS, Hyun DY, Linder JA, et al. Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010–2011. JAMA. 2016;315(17):1864–73.CrossRefPubMed
7.
go back to reference Goossens H, Ferech M, Vander Stichele R, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet. 2005;365(9459):579–87.CrossRefPubMed Goossens H, Ferech M, Vander Stichele R, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet. 2005;365(9459):579–87.CrossRefPubMed
8.
go back to reference Cenzato F, Milani GP, Amigoni A, Sperotto F, Bianchetti MG, Agostoni C, Montini G. Diagnosis and management of urinary tract infections in children aged 2 months to 3 years in the Italian emergency units: the ItaUTI study. Eur J Pediatr. 2022;181(7):2663–71.CrossRefPubMedPubMedCentral Cenzato F, Milani GP, Amigoni A, Sperotto F, Bianchetti MG, Agostoni C, Montini G. Diagnosis and management of urinary tract infections in children aged 2 months to 3 years in the Italian emergency units: the ItaUTI study. Eur J Pediatr. 2022;181(7):2663–71.CrossRefPubMedPubMedCentral
9.
go back to reference Principi N, Marchisio P, Calanchi A, Onorato J, Plebani A, Reali E, Rancilio L, Grasso E, Magni L, Caramia G, et al. Streptococcal pharyngitis in Italian children: epidemiology and treatment with miocamycin. Drugs Exp Clin Res. 1990;16(12):639–47.PubMed Principi N, Marchisio P, Calanchi A, Onorato J, Plebani A, Reali E, Rancilio L, Grasso E, Magni L, Caramia G, et al. Streptococcal pharyngitis in Italian children: epidemiology and treatment with miocamycin. Drugs Exp Clin Res. 1990;16(12):639–47.PubMed
10.
go back to reference Cohen JF, Pauchard JY, Hjelm N, Cohen R, Chalumeau M. Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat. Cochrane Database Syst Rev. 2020;6(6):Cd012431.PubMed Cohen JF, Pauchard JY, Hjelm N, Cohen R, Chalumeau M. Efficacy and safety of rapid tests to guide antibiotic prescriptions for sore throat. Cochrane Database Syst Rev. 2020;6(6):Cd012431.PubMed
11.
go back to reference Cohen JF, Bertille N, Cohen R, Chalumeau M. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016;7(7):Cd010502.PubMed Cohen JF, Bertille N, Cohen R, Chalumeau M. Rapid antigen detection test for group A streptococcus in children with pharyngitis. Cochrane Database Syst Rev. 2016;7(7):Cd010502.PubMed
12.
go back to reference Cardoso DM, Gilio AE, Hsin SH, Machado BM, de Paulis M, Lotufo JP, Martinez MB, Grisi SJ. Impact of the rapid antigen detection test in diagnosis and treatment of acute pharyngotonsillitis in a pediatric emergency room. Rev Paul Pediatr. 2013;31(1):4–9.CrossRefPubMed Cardoso DM, Gilio AE, Hsin SH, Machado BM, de Paulis M, Lotufo JP, Martinez MB, Grisi SJ. Impact of the rapid antigen detection test in diagnosis and treatment of acute pharyngotonsillitis in a pediatric emergency room. Rev Paul Pediatr. 2013;31(1):4–9.CrossRefPubMed
13.
go back to reference Robinson JL. Paediatrics: how to manage pharyngitis in an era of increasing antimicrobial resistance. Drugs Context. 2020;2021:10. Robinson JL. Paediatrics: how to manage pharyngitis in an era of increasing antimicrobial resistance. Drugs Context. 2020;2021:10.
14.
go back to reference Cohen R, Levy C, Doit C, De La Rocque F, Boucherat M, Fitoussi F, Langue J, Bingen E. Six-day amoxicillin vs. ten-day penicillin V therapy for group A streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 1996;15(8):678–82.CrossRefPubMed Cohen R, Levy C, Doit C, De La Rocque F, Boucherat M, Fitoussi F, Langue J, Bingen E. Six-day amoxicillin vs. ten-day penicillin V therapy for group A streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 1996;15(8):678–82.CrossRefPubMed
15.
go back to reference Salvo F, Polimeni G, Moretti U, Conforti A, Leone R, Leoni O, Motola D, Dusi G, Caputi AP. Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy. J Antimicrob Chemother. 2007;60(1):121–6.CrossRefPubMed Salvo F, Polimeni G, Moretti U, Conforti A, Leone R, Leoni O, Motola D, Dusi G, Caputi AP. Adverse drug reactions related to amoxicillin alone and in association with clavulanic acid: data from spontaneous reporting in Italy. J Antimicrob Chemother. 2007;60(1):121–6.CrossRefPubMed
16.
go back to reference Kuehn J, Ismael Z, Long PF, Barker CI, Sharland M. Reported rates of diarrhea following oral penicillin therapy in pediatric clinical trials. J Pediatr Pharmacol Ther. 2015;20(2):90–104.PubMedPubMedCentral Kuehn J, Ismael Z, Long PF, Barker CI, Sharland M. Reported rates of diarrhea following oral penicillin therapy in pediatric clinical trials. J Pediatr Pharmacol Ther. 2015;20(2):90–104.PubMedPubMedCentral
17.
18.
go back to reference de Bie S, Kaguelidou F, Verhamme KM, De Ridder M, Picelli G, Straus SM, Giaquinto C, Stricker BH, Bielicki J, Sharland M, et al. Using Prescription Patterns in Primary Care to Derive New Quality Indicators for Childhood Community Antibiotic Prescribing. Pediatr Infect Dis J. 2016;35(12):1317–23.CrossRefPubMed de Bie S, Kaguelidou F, Verhamme KM, De Ridder M, Picelli G, Straus SM, Giaquinto C, Stricker BH, Bielicki J, Sharland M, et al. Using Prescription Patterns in Primary Care to Derive New Quality Indicators for Childhood Community Antibiotic Prescribing. Pediatr Infect Dis J. 2016;35(12):1317–23.CrossRefPubMed
19.
go back to reference Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D. Why do paediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2009;9:69.CrossRefPubMedPubMedCentral Moro ML, Marchi M, Gagliotti C, Di Mario S, Resi D. Why do paediatricians prescribe antibiotics? Results of an Italian regional project. BMC Pediatr. 2009;9:69.CrossRefPubMedPubMedCentral
20.
go back to reference Barbieri E, Donà D, Cantarutti A, Lundin R, Scamarcia A, Corrao G, Cantarutti L, Giaquinto C. Antibiotic prescriptions in acute otitis media and pharyngitis in Italian pediatric outpatients. Ital J Pediatr. 2019;45(1):103.CrossRefPubMedPubMedCentral Barbieri E, Donà D, Cantarutti A, Lundin R, Scamarcia A, Corrao G, Cantarutti L, Giaquinto C. Antibiotic prescriptions in acute otitis media and pharyngitis in Italian pediatric outpatients. Ital J Pediatr. 2019;45(1):103.CrossRefPubMedPubMedCentral
21.
go back to reference Flood SM, Desai NM, Leonard JE, Mistry RD. Emergency Department Prescribing Patterns for Pharyngitis in Children. Clin Pediatr (Phila). 2020;59(11):995–1003.CrossRefPubMed Flood SM, Desai NM, Leonard JE, Mistry RD. Emergency Department Prescribing Patterns for Pharyngitis in Children. Clin Pediatr (Phila). 2020;59(11):995–1003.CrossRefPubMed
22.
go back to reference Alberio AMQ, Pieroni F, Di Gangi A, Cappelli S, Bini G, Abu-Rumeileh S, Orsini A, Bonuccelli A, Peroni D, Assanta N, et al. Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy. Front Pediatr. 2021;9: 746505.CrossRefPubMedPubMedCentral Alberio AMQ, Pieroni F, Di Gangi A, Cappelli S, Bini G, Abu-Rumeileh S, Orsini A, Bonuccelli A, Peroni D, Assanta N, et al. Toward the Knowledge of the Epidemiological Impact of Acute Rheumatic Fever in Italy. Front Pediatr. 2021;9: 746505.CrossRefPubMedPubMedCentral
Metadata
Title
Nationwide survey on the management of pediatric pharyngitis in Italian emergency units
Authors
Gregorio P. Milani
Claudio Rosa
Naz Tuzger
Ilaria Alberti
Chiara Ghizzi
Stefania Zampogna
Angela Amigoni
Carlo Agostoni
Diego Peroni
Paola Marchisio
Elena Chiappini
IPSE study group
Publication date
01-12-2023
Publisher
BioMed Central
Published in
Italian Journal of Pediatrics / Issue 1/2023
Electronic ISSN: 1824-7288
DOI
https://doi.org/10.1186/s13052-023-01514-8

Other articles of this Issue 1/2023

Italian Journal of Pediatrics 1/2023 Go to the issue