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01-08-2018 | Original Article

Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats

Authors: Mohammad Ibrahim, Musadiq Ibrahim, Niaz Muhammad, Muhammad Ishaq Ali Shah, Gerlânia de Oliveira Leite, Joao B. T. Rocha

Published in: Inflammopharmacology | Issue 4/2018

Abstract

Selenium (Se) is a dietary essential trace element with important biological roles. It is a nutrient related to the complex metabolic and enzymatic functions. Organoselenium compounds have been reported to have anti-ulcer activity and used as drug for the treatment of gastrointestinal disorders. The antiulcer activity of binapthyl diselenide (NapSe)2 was investigated in ethanol-induced gastric lesions in rats. A number of markers of oxidative stress were examined in rats stomach including thiobarbituric acid reactive species (TBARS), catalase (CAT), superoxide dismutase (SOD), non-protein thiol groups (NPSH) and ascorbic acid. (NapSe)2 was found to be significantly restoring the deficits in the antioxidant defense mechanisms (CAT, SOD, NPSH and ascorbic acid), and suppressed lipid peroxidation in rat stomach resulting from EtOH administration. It is experimentally concluded that ethanol exposure causes alterations in the antioxidant defense system and induces oxidative stress in rat stomach. These studies establish a promising foundation for investigating and understanding the beneficial effects of organoselenium compounds on human health. Moreover, (NaPSe)₂ deserves further investigation as a therapeutic and preventive agent against gastric ulcer in humans.

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Title: Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats
Authors: Mohammad Ibrahim
Musadiq Ibrahim
Niaz Muhammad
Muhammad Ishaq Ali Shah
Gerlânia de Oliveira Leite
Joao B. T. Rocha
Publication date: 01-08-2018
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 4/2018
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-018-0451-7

At a glance: The STEP trials

Springer Medicine

Pharmacological mechanisms underlying gastroprotective activities of binapthyl diselenide in Wistar rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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