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01-08-2018 | Original Article

Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats

Authors: Abdulaziz S. Saeedan, Indu Singh, Mohd. Nazam Ansari, Manjari Singh, Jitendra K. Rawat, Uma Devi, Swetlana Gautam, Rajnish K. Yadav, Gaurav Kaithwas

Published in: Inflammopharmacology | Issue 4/2018

Abstract

The present study was aimed to test the hypothesis that paracetamol (PCM) can precipitate autistic like features when used to counteract vaccine-induced fever using experimental rat pups. The pups were treated with measles mumps rubella (MMR) vaccine, diphtheria tetanus and pertussis (DPT) vaccines and lipopolysaccharide (LPS) with subsequent PCM treatment. The pups were evaluated for postnatal growth (weight gain, eye opening) and behavior alterations (swimming performance, olfactory discrimination, negative geotaxis, nociception, and locomotor activity) by performing battery of neurobehavioral test. Significant correlation was observed between social behavioral domains (nociception, anxiety and motor coordination) and pro-inflammatory load in the pups when treated with MMR/LPS along with PCM. A significant change in pro and anti-inflammatory (IL-4, IL-6, IL-10) markers were observed in rats treated with PCM, MMR, LPS, DPS alone or in combination with MMR, LPS and DPT (5128.6 ± 0.000, 15,488 ± 0.000^***, 9661.1 ± 157.29^***a, 15,312 ± 249.29^***, 10,471 ± 0.00^***a, 16,789 ± 273.34^*** and 12,882 ± 0.00^***a). Pups were also scrutinized for the markers of oxidative stress, inflammation and histopathologically. All the treatment groups showed significant alteration in the behavioral changes, oxidative markers (TBARS-in control-4.33 ± 0.02, PCM-9.42 ± 0.18^***, MMR-5.27 ± 0.15^***, MMR + PCM-8.57 ± 0.18^{*** a}, LPS-6.84 ± 0.10^***, LPS + PCM-4.51 ± 0.30^***a, DPT-5.68 ± 0.12^***, DPT + PCM-7.26 ± 0.18^***a) and inflammatory markers without following any specific treatment. These observation could be accorded to variable phenotypes of autistic spectrum disorders (ASDs).

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Title: Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats
Authors: Abdulaziz S. Saeedan
Indu Singh
Mohd. Nazam Ansari
Manjari Singh
Jitendra K. Rawat
Uma Devi
Swetlana Gautam
Rajnish K. Yadav
Gaurav Kaithwas
Publication date: 01-08-2018
Publisher: Springer International Publishing
Published in: Inflammopharmacology / Issue 4/2018
Print ISSN: 0925-4692
Electronic ISSN: 1568-5608
DOI: https://doi.org/10.1007/s10787-017-0440-2

At a glance: The STEP trials

Springer Medicine

Effect of early natal supplementation of paracetamol on attenuation of exotoxin/endotoxin induced pyrexia and precipitation of autistic like features in albino rats

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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