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European Journal of Nuclear Medicine and Molecular Imaging

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01-10-2013 | Image of the Month

PET/MRI with a ⁶⁸Ga-PSMA ligand for the detection of prostate cancer

Authors: Ali Afshar-Oromieh, Uwe Haberkorn, Boris Hadaschik, Gregor Habl, Matthias Eder, Michael Eisenhut, Heinz-Peter Schlemmer, Matthias C. Roethke

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 10/2013

Excerpt

In the past few months, several reports have been published about a novel and highly promising method involving PET imaging with radiolabelled prostate-specific membrane antigen (PSMA) ligands [1‐4]. Here, we present the first case of a whole-body PET/MRI with the ⁶⁸Ga-labelled PSMA ligand Glu-NH-CO-NH-Lys(Ahx)-HBED-CC. …

Eder M, Schäfer M, Bauder-Wüst U, Hull WE, Wangler C, Mier W, et al. 68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging. Bioconjug Chem. 2012;23:688–97.PubMedCrossRef

Afshar-Oromieh A, Haberkorn U, Eder M, Eisenhut M, Zechmann C. [68Ga]Gallium-labelled PSMA ligand as superior PET tracer for the diagnosis of prostate cancer: comparison with 18F-FECH. Eur J Nucl Med Mol Imaging. 2012;39(6):1085–6.PubMedCrossRef

Afshar-Oromieh A, Malcher A, Eder M, Eisenhut M, Linhart HG, Hadaschik BA, et al. PET imaging with a [68Ga]Gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging. 2013;40(4):486–95.PubMedCrossRef

Barrett JA, Coleman RE, Goldsmith SJ, Vallabhajosula S, Petry NA, Cho S, et al. First-in-man evaluation of 2 high-affinity PSMA-avid small molecules for imaging prostate cancer. J Nucl Med 2013;54(3):380–7.PubMedCrossRef

Title: PET/MRI with a 68Ga-PSMA ligand for the detection of prostate cancer
Authors: Ali Afshar-Oromieh
Uwe Haberkorn
Boris Hadaschik
Gregor Habl
Matthias Eder
Michael Eisenhut
Heinz-Peter Schlemmer
Matthias C. Roethke
Publication date: 01-10-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 10/2013
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2489-5

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PET/MRI with a ⁶⁸Ga-PSMA ligand for the detection of prostate cancer

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