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BMC Pulmonary Medicine
Published in: BMC Pulmonary Medicine 1/2009

Open Access 01-12-2009 | Research article

Persistence of oxidant and protease burden in the airways after smoking cessation

Authors: Noora Louhelainen, Paula Rytilä, Tari Haahtela, Vuokko L Kinnula, Ratko Djukanović

Published in: BMC Pulmonary Medicine | Issue 1/2009

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Abstract

Background

Oxidative stress is associated with the pathogenesis of cigarette smoke related lung diseases, but longitudinal effects of smoking cessation on oxidant markers in the airways are unknown.

Methods

This study included 61 smokers; 21 with chronic bronchitis or COPD, 15 asthmatics and 25 asymptomatic smokers followed up for 3 months after smoking cessation. Fractional exhaled nitric oxide (FeNO), sputum neutrophil counts, sputum 8-isoprostane, nitrotyrosine and matrix metalloproteinase-8 (MMP-8) were investigated at baseline and 1 and 3 months after smoking cessation.

Results

After 3 months 15 subjects had succeeded in quitting of smoking and in these subjects symptoms improved significantly. Unexpectedly, however, sputum neutrophils increased (p = 0.046) after smoking cessation in patients with chronic bronchitis/COPD. At baseline, the other markers did not differ between the three groups so these results were combined for further analysis. Sputum 8-isoprostane declined significantly during the follow-up at 3 months (p = 0.035), but levels still remained significantly higher than in non-smokers. The levels of FeNO, nitrotyrosine and MMP-8 did not change significantly during the 3 months after smoking cessation.

Conclusion

Whilst symptoms improve after smoking cessation, the oxidant and protease burden in the airways continues for months.
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Metadata
Title
Persistence of oxidant and protease burden in the airways after smoking cessation
Authors
Noora Louhelainen
Paula Rytilä
Tari Haahtela
Vuokko L Kinnula
Ratko Djukanović
Publication date
01-12-2009
Publisher
BioMed Central
Published in
BMC Pulmonary Medicine / Issue 1/2009
Electronic ISSN: 1471-2466
DOI
https://doi.org/10.1186/1471-2466-9-25

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