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Published in: BMC Nephrology 1/2024

Open Access 01-12-2024 | Peritoneal Dialysis | Research

Risk factors for short-term all-cause mortality in patients with end stage renal disease: a scoping review

Authors: Wanfen Yip, Sheryl Hui Xian Ng, Palvinder Kaur, Pradeep Paul George, Jennifer Huey Chen Guan, Guozhang Lee, Timothy Jee Kam Koh, Woan Shin Tan, Allyn Yin Mei Hum

Published in: BMC Nephrology | Issue 1/2024

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Abstract

Objectives

There is a lack of prognostic information to guide the prediction of short-term all-cause mortality in patients with end-stage renal disease (ESRD). The aim was to review the risk factors that influenced the risk of short-term all-cause mortality in patients with ESRD.

Methods

MEDLINE, Embase, PubMed, CINAHL, the Cochrane Library and Web of Science databases were searched for articles published between 2000 and 2020. Articles describing risk factors predicting short-term mortality (≤ 3 years) in patients with ESRD were included. Four reviewers independently performed title, abstract, full text screening and data extraction. Assessment of risk of bias was assessed using the Quality In Prognosis Studies (QUIPS) tool checklist.

Results

20,840 articles were identified and 113 papers were included for this review. Of the 113 papers, 6.2% included only peritoneal dialysis (PD) patients, 67.3% included only hemodialysis (HD) patients, 20.4% included both PD and HD patients, with the remaining papers featuring patients on conservative management or awaiting renal transplant. Risk factors were categorised into 13 domains: 1)demographics/ lifestyle, 2) comorbidities 3)intradialytic blood pressure, 4)biomarkers, 5)cardiovascular measurements, 6)frailty status, 7)medications, 8)treatment related indicators, 9)renal related parameters, 10)health status, 11)cause of ESRD, 12)access to healthcare care/ information and, 13)proxy measures for poor health. C-reactive protein(CRP), age, and functional status were observed to have higher percentage of instances of being significantly associated with all-cause mortality.

Conclusion

Commonly examined risk factors observed from this review may be used to build a general prognostic model for patients with ESRD, with specific treatment related risk factors added on to enhance the accuracy of the models.
Appendix
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Metadata
Title
Risk factors for short-term all-cause mortality in patients with end stage renal disease: a scoping review
Authors
Wanfen Yip
Sheryl Hui Xian Ng
Palvinder Kaur
Pradeep Paul George
Jennifer Huey Chen Guan
Guozhang Lee
Timothy Jee Kam Koh
Woan Shin Tan
Allyn Yin Mei Hum
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2024
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-024-03503-3

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