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Respiratory Research
Published in: Respiratory Research 1/2016

Open Access 01-12-2016 | Letter to the Editor

Periplakin is a target for autoimmunity in asthma

Authors: Camille Taillé, Sabine Grootenboer-Mignot, Candice Estellat, Carine Roy, Sophie Ly Ka So, Marina Pretolani, Michel Aubier, Bruno Crestani, Sylvie Chollet-Martin

Published in: Respiratory Research | Issue 1/2016

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Abstract

The role of autoimmunity targeting epithelial antigens in asthma has been suggested, in particular in non-atopic and severe asthma. Periplakin, a desmosomal component, is involved in epithelial cohesion and intracellular signaling. We detected anti-periplakin IgG antibodies in 47/260 (18 %) patients with asthma, with no association with severity or atopy. In addition, anti-periplakin IgE antibodies were detected in 12 of 138 tested patients (8.7 %) and were more frequently observed in patients with than without nasal polyposis. This study identifies a new autoimmune epithelial target in asthma. Whether periplakin autoimmunity (both IgG and IgE auto-antibodies) is involved in asthma pathogenesis remains to be studied during the disease course of these patients.
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Metadata
Title
Periplakin is a target for autoimmunity in asthma
Authors
Camille Taillé
Sabine Grootenboer-Mignot
Candice Estellat
Carine Roy
Sophie Ly Ka So
Marina Pretolani
Michel Aubier
Bruno Crestani
Sylvie Chollet-Martin
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2016
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-016-0441-5

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