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01-06-2018 | Gynecologic Oncology

Peri-operative oral immunonutrition in malnourished ovarian cancer patients assessed by the nutritional risk screening

Authors: Linda Hertlein, Christine Zeder-Göß, Sophie Fürst, Daniela Bayer, Fabian Trillsch, Bastian Czogalla, Sven Mahner, Alexander Burges, Peter Rittler

Published in: Archives of Gynecology and Obstetrics | Issue 6/2018

Abstract

Objectives

Aim of this study was to determine whether peri-operative immunonutrition can decrease complications and the length of stay (LOS) in malnourished ovarian cancer patients.

Study design

Patients suspicious for advanced ovarian cancer before histopathological diagnosis and a nutritional risk score (NRS) ≥ 3 received oral immune-modulating diets (IMDs) for 5 days pre-operative and at least 5 days post-operative. Parameters for clinical outcome were infectious and non-infectious complications during hospital stay, and time of hospitalization. The results were compared with malnourished ovarian cancer patients of a previous study without any additive nutritional support (standard clinical diet/nutrition).

Results

The infectious and non-infectious complication rate in the interventional group (IG) N = 28 was 42.9%, similar to the control group (CG) N = 19 with 42.1%, whereas the rate of infectious complications in the IG (21.4%) was slightly lower compared to the CG (26.3%). The median LOS of the IG was 18 days, and therefore, longer than LOS of the CG (15 days). Regarding the patients’ compliance pre-operative 78.6% of the patients took the IMDs in an optimal and sufficient amount. Whereas after surgery, only eight (28.6%) patients were able to take IMDs in optimal and sufficient amount.

Conclusions

The current study showed no improvement of the complication rate or the time of hospitalization due to additional peri-operative immunonutrition in malnourished ovarian cancer patients. However, a trend towards the reduction of infectious complications could be seen in the IG.

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Title: Peri-operative oral immunonutrition in malnourished ovarian cancer patients assessed by the nutritional risk screening
Authors: Linda Hertlein
Christine Zeder-Göß
Sophie Fürst
Daniela Bayer
Fabian Trillsch
Bastian Czogalla
Sven Mahner
Alexander Burges
Peter Rittler
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4759-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Peri-operative oral immunonutrition in malnourished ovarian cancer patients assessed by the nutritional risk screening

Abstract

Objectives

Study design

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objectives

Study design

Results

Conclusions

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