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Archives of Gynecology and Obstetrics

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01-06-2018 | Gynecologic Endocrinology and Reproductive Medicine

Can ebselen prevent cisplatin-induced ovarian damage?

Authors: Zeynep Soyman, Hafize Uzun, Nihan Bayindir, Mukaddes Esrefoglu, Birtan Boran

Published in: Archives of Gynecology and Obstetrics | Issue 6/2018

Abstract

Purpose

The occurrence of ovarian damage is a major shortcoming in treating tumors with cisplatin (CP). The present study investigates the beneficial effects of ebselen—a seleno-organic compound with antioxidant and antiinflammatory properties—vis-à-vis CP-induced ovarian damage.

Methods

Twenty-eight adult female rats were divided into four study groups. Group 1 received no treatment. The rats in Groups 2, 3, and 4 were intraperitoneally administered CP (2 mg/kg/day) twice per week, for 5 weeks. Those in Group 2 received 0.3 ml saline (0.9% NaCl) intraperitoneally 60 min before each CP treatment, while those in Group 3 received 0.2 ml dimethyl sulfoxide (DMSO) and 0.3 ml saline intraperitoneally 60 min before each CP treatment. The rats in Group 4 were pretreated with an intraperitoneal injection of 15 mg/kg/day ebselen 60 min before each CP treatment. Ovarian tissue malondialdehyde (MDA), total nitric oxide (NOx), glutathione (GSH), Cu/Zn-superoxide dismutase (Cu/Zn-SOD), and catalase levels, as well as histopathological damage scores (HDSs) and serum antimullerian hormone (AMH) levels, were assessed.

Results

Cu/Zn-SOD and GSH levels were significantly higher, and MDA and NOx levels significantly lower, in Group 4 than in Groups 2 and 3. Pretreatment with ebselen significantly improved serum AMH levels, relative to Groups 2 and 3. Additionally, HDS values were significantly lower in Group 4 than in Groups 2 and 3.

Conclusions

Our results from using an experimental rat model of CP chemotherapy suggest that ebselen use may ameliorate ovarian damage by preventing oxidative injury.

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Title: Can ebselen prevent cisplatin-induced ovarian damage?
Authors: Zeynep Soyman
Hafize Uzun
Nihan Bayindir
Mukaddes Esrefoglu
Birtan Boran
Publication date: 01-06-2018
Publisher: Springer Berlin Heidelberg
Published in: Archives of Gynecology and Obstetrics / Issue 6/2018
Print ISSN: 0932-0067
Electronic ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-018-4750-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Can ebselen prevent cisplatin-induced ovarian damage?

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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