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International Journal of Implant Dentistry

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Open Access 01-12-2020 | Peri-Implant Diseases in the Maxillofacial Region | Research

Comparison of peri-implant soft tissue and crestal bone status of dental implants placed in prediabetic, type 2 diabetic, and non-diabetic individuals: a retrospective cohort study

Authors: Abdullah Alshahrani, Modhi Al Deeb, Saad Alresayes, Sameer A. Mokeem, Nawwaf Al-Hamoudi, Osama Alghamdi, Fahim Vohra, Tariq Abduljabbar

Published in: International Journal of Implant Dentistry | Issue 1/2020

Abstract

Background

Clinicoradiographic status of narrow-diameter implants (NDIs) among patients with prediabetes and type 2 diabetes mellitus (DM) is scarce. The aim was to address the clinicoradiographic status of NDIs placed prediabetic, type 2 diabetic, and non-diabetic individuals. In this retrospective cohort study, patients having undergone oral rehabilitation with NDI were included. The participants were divided into the following: (a) patients with prediabetes; (b) patients with poorly controlled type 2 DM; (c) patients with well-controlled type 2 DM; and (d) normoglycemic individuals. Demographic data was collected. In all groups, peri-implant plaque index (PI), gingival index (GI), probing depth (PD), and mesiodistal CBL were measured in all groups. Information related to implant dimensions, surface characteristics, insertion torque, implant geometry, duration of NDI in function, and jaw location of NDI was also recorded. Data normality was assessed and group comparisons were performed. A probability value under 0.01 was considered statistically significant.

Results

Eighty-three patients (20 patients had prediabetes, 22 with poorly controlled type 2 DM, 20 with well-controlled type 2 DM, and 20 self-reported non-diabetic individuals) were included. The mean HbA1c levels were significantly higher among patients with prediabetes (P < 0.01) and poorly controlled type 2 DM (P < 0.01) than patients with well-controlled type 2 DM and non-diabetic controls. Peri-implant PI, GI, PD, and mesiodistal CBL levels were significantly higher among patients with pre-diabetes (P < 0.01) and poorly controlled type 2 DM (P < 0.01) than patients with well-controlled type 2 DM and non-diabetic controls. Peri-implant PI, GI, PD, and mesiodistal CBL levels were significantly higher among patients with poorly controlled type 2 DM (P < 0.01) than patients with prediabetes.

Conclusion

Chronic hyperglycemia increases the risk of peri-implant diseases around NDIs.

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Schiegnitz E, Al-Nawas B. Narrow-diameter implants: a systematic review and meta-analysis. Clin Oral Implants Res. 2018;29(Suppl 16):21–40 https://10.1111/clr.13272.CrossRef

Assaf A, Saad M, Daas M, Abdallah J, Abdallah R. Use of narrow-diameter implants in the posterior jaw: a systematic review. Implant Dent. 2015;24(3):294–306 https://10.1097/id.0000000000000238.PubMed

Klein MO, Schiegnitz E, Al-Nawas B. Systematic review on success of narrow-diameter dental implants. Int J Oral Maxillofac Implants 2014;29 Suppl; 43-54. https://10.11607/jomi.2014suppl.g1.3.

Chang YY, Kim SH, Park KO, Yun JH. Evaluation of a reverse-tapered design on the osseointegration of narrow-diameter implants in beagle dogs: a pilot study. Int J Oral Maxillofac Implants. 2016;31(3):611–20 https://10.11607/jomi.4260.CrossRef

Alrabiah M. Comparison of survival rate and crestal bone loss of narrow diameter dental implants versus regular dental implants: a systematic review and meta-analysis. J Investig Clin Dent. 2019;10(1):e12367 https://10.1111/jicd.12367.CrossRef

Alasqah M, Mokeem S, Alrahlah A, et al. Periodontal parameters in prediabetes, type 2 diabetes mellitus, and non-diabetic patients. Braz Oral Res. 2018;32:e81 https://10.1590/1807-3107bor-2018.vol32.0081.CrossRef

Alrabiah M, Alrahlah A, Al-Hamdan RS, Al-Aali KA, Labban N, Abduljabbar T. Survival of adjacent-dental-implants in prediabetic and systemically healthy subjects at 5-years follow-up. Clin Implant Dent Relat Res. 2019;21(2):232–7 https://10.1111/cid.12715.CrossRef

Javed F, Näsström K, Benchimol D, Altamash M, Klinge B, Engström PE. Comparison of periodontal and socioeconomic status between subjects with type 2 diabetes mellitus and non-diabetic controls. J Periodontol. 2007;78(11):2112–9 https://10.1902/jop.2007.070186.CrossRef

Al Amri MD, Abduljabbar TS, Al-Kheraif AA, Romanos GE, Javed F. Comparison of clinical and radiographic status around dental implants placed in patients with and without prediabetes: 1-year follow-up outcomes. Clin Oral Implants Res. 2017;28(2):231–5 https://10.1111/clr.12788.CrossRef

10.

Alasqah MN, Alrabiah M, Al-Aali KA, et al. Peri-implant soft tissue status and crestal bone levels around adjacent implants placed in patients with and without type-2 diabetes mellitus: 6 years follow-up results. Clin Implant Dent Relat Res. 2018;20(4):562–8 https://10.1111/cid.12617.CrossRef

11.

Al-Shibani N, Al-Aali KA, Al-Hamdan RS, Alrabiah M, Basunbul G, Abduljabbar T. Comparison of clinical peri-implant indices and crestal bone levels around narrow and regular diameter implants placed in diabetic and non-diabetic patients: a 3-year follow-up study. Clin Implant Dent Relat Res. 2019;21(2):247–52 https://10.1111/cid.12712.CrossRef

12.

Mokeem S, Alfadda SA, Al-Shibani N, et al. Clinical and radiographic peri-implant variables around short dental implants in type 2 diabetic, prediabetic, and non-diabetic patients. Clin Implant Dent Relat Res. 2019;21(1):60–5 https://10.1111/cid.12691.CrossRef

13.

Naujokat H, Kunzendorf B, Wiltfang J. Dental implants and diabetes mellitus-a systematic review. Int J Implant Dent. 2016;2(1):5 https://10.1186/s40729-016-0038-2.CrossRef

14.

Katz J, Wallet S, Cha S. Periodontal disease and the oral-systemic connection: “is it all the RAGE?”. Quintessence Int. 2010;41(3):229–37.PubMed

15.

Katz J, Yoon TY, Mao S, Lamont RJ, Caudle RM. Expression of the receptor of advanced glycation end products in the gingival tissue of smokers with generalized periodontal disease and after nornicotine induction in primary gingival epithelial cells. J Periodontol. 2007;78(4):736–41 https://10.1902/jop.2007.060381.CrossRef

16.

Quintero DG, Winger JN, Khashaba R, Borke JL. Advanced glycation endproducts and rat dental implant osseointegration. J Oral Implantol. 2010;36(2):97–103 https://10.1563/aaid-joi-d-09-00032.CrossRef

17.

Alrabiah M, Al-Aali KA, Al-Sowygh ZH, Binmahfooz AM, Mokeem SA, Abduljabbar T. Association of advanced glycation end products with peri-implant inflammation in prediabetes and type 2 diabetes mellitus patients. Clin Implant Dent Relat Res. 2018;20(4):535–40 https://10.1111/cid.12607.CrossRef

18.

Javed F, Romanos GE. Impact of diabetes mellitus and glycemic control on the osseointegration of dental implants: a systematic literature review. J Periodontol. 2009;80(11):1719–30 https://10.1902/jop.2009.090283.CrossRef

19.

Olson DE, Rhee MK, Herrick K, Ziemer DC, Twombly JG, Phillips LS. Screening for diabetes and pre-diabetes with proposed A1C-based diagnostic criteria. Diabetes Care. 2010;33(10):2184–9 https://10.2337/dc10-0433.CrossRef

20.

Stadler M, Frohlich-Reiterer E, Prager R. Type 2 Diabetes mellitus-screening and prevention: update 2016. Wien Klin Wochenschr. 2016;128(Suppl 2):S41–4 https://10.1007/s00508-016-0971-3.CrossRef

21.

Akram Z, Alqahtani F, Alqahtani M, Al-Kheraif AA, Javed F. Levels of advanced glycation end products in gingival crevicular fluid of chronic periodontitis patients with and without type-2 diabetes mellitus. J Periodontol. 2019; https://10.1002/jper.19-0209.

22.

Al-Sowygh ZH, Ghani SMA, Sergis K, Vohra F, Akram Z. Peri-implant conditions and levels of advanced glycation end products among patients with different glycemic control. Clin Implant Dent Relat Res. 2018;20(3):345–51 https://10.1111/cid.12584.CrossRef

23.

Kilpatrick ES, Bloomgarden ZT, Zimmet PZ. International expert committee report on the role of the A1C assay in the diagnosis of diabetes: response to the International Expert Committee. Diabetes Care. 2009;32(12):e159 author reply e60. https://10.2337/dc09-1231.CrossRef

24.

Sherwani SI, Khan HA, Ekhzaimy A, Masood A, Sakharkar MK. Significance of HbA1c test in diagnosis and prognosis of diabetic patients. Biomark Insights. 2016;11:95–104 https://10.4137/bmi.S38440.CrossRef

25.

Li G, Han L, Wang Y, et al. Evaluation of ADA HbA1c criteria in the diagnosis of pre-diabetes and diabetes in a population of Chinese adolescents and young adults at high risk for diabetes: a cross-sectional study. BMJ Open. 2018;8(8):e020665 https://10.1136/bmjopen-2017-020665.CrossRef

26.

Loe H. The gingival index, the plaque index and the retention index systems. J Periodontol 1967;38(6):610-6. https://10.1902/jop.1967.38.6.610.

27.

Armitage GC, Svanberg GK, Loe H. Microscopic evaluation of clinical measurements of connective tissue attachment levels. J Clin Periodontol. 1977;4(3):173–90.CrossRef

28.

Updegrave WJ. The paralleling extension-cone technique in intraoral dental radiography. Oral Surg Oral Med Oral Pathol. 1951;4(10):1250–61.CrossRef

29.

Khocht A, Janal M, Harasty L, Chang KM. Comparison of direct digital and conventional intraoral radiographs in detecting alveolar bone loss. J Am Dent Assoc. 2003;134(11):1468–75.CrossRef

30.

Javed F, Al-Kheraif AA, Al Amri MD, et al. Periodontal parameters and whole salivary cytokine profiles among habitual gutka chewers and non-chewers. J Periodontol. 2015;86(5):689–95 https://10.1902/jop.2015.140556.CrossRef

31.

Abduljabbar T, Al-Sahaly F, Al-Kathami M, Afzal S, Vohra F. Comparison of periodontal and peri-implant inflammatory parameters among patients with prediabetes, type 2 diabetes mellitus and non-diabetic controls. Acta Odontol Scand. 2017;75(5):319–24 https://10.1080/00016357.2017.1303848.CrossRef

32.

Nonaka K, Kajiura Y, Bando M, et al. Advanced glycation end-products increase IL-6 and ICAM-1 expression via RAGE, MAPK and NF-kappaB pathways in human gingival fibroblasts. J Periodontal Res. 2018;53(3):334–44 https://10.1111/jre.12518.CrossRef

33.

Li Z, Li C, Zhou Y, et al. Advanced glycation end products biphasically modulate bone resorption in osteoclast-like cells. Am J Physiol Endocrinol Metab. 2016;310(5):E355–66 https://10.1152/ajpendo.00309.2015.CrossRef

34.

Shim E, Babu JP. Glycated albumin produced in diabetic hyperglycemia promotes monocyte secretion of inflammatory cytokines and bacterial adherence to epithelial cells. J Periodontal Res. 2015;50(2):197–204 https://10.1111/jre.12194.CrossRef

35.

Takeda M, Ojima M, Yoshioka H, et al. Relationship of serum advanced glycation end products with deterioration of periodontitis in type 2 diabetes patients. J Periodontol. 2006;77(1):15–20 https://10.1902/jop.2006.77.1.15.CrossRef

36.

Javed F, Romanos GE. Chronic hyperglycemia as a risk factor in implant therapy. Periodontol 2000. 2019;81(1):57–63 https://10.1111/prd.12283.CrossRef

37.

Oates TW, Dowell S, Robinson M, McMahan CA. Glycemic control and implant stabilization in type 2 diabetes mellitus. J Dent Res. 2009;88(4):367–71 https://10.1177/0022034509334203.CrossRef

38.

Almutairi AS, Walid MA, Alkhodary MA. The effect of osseodensification and different thread designs on the dental implant primary stability. F1000Res. 2018;7:1898 https://10.12688/f1000research.17292.1.CrossRef

39.

Schillinger D, Grumbach K, Piette J, et al. Association of health literacy with diabetes outcomes. Jama. 2002;288(4):475–82 https://10.1001/jama.288.4.475.CrossRef

40.

Shilubane NH, Cur M. Factors contributing to poor glycaemic control in diabetic patients at Mopani District. Curationis. 2010;33(3):43–7 https://10.4102/curationis.v33i3.6.CrossRef

Title: Comparison of peri-implant soft tissue and crestal bone status of dental implants placed in prediabetic, type 2 diabetic, and non-diabetic individuals: a retrospective cohort study
Authors: Abdullah Alshahrani
Modhi Al Deeb
Saad Alresayes
Sameer A. Mokeem
Nawwaf Al-Hamoudi
Osama Alghamdi
Fahim Vohra
Tariq Abduljabbar
Publication date: 01-12-2020
Publisher: Springer Berlin Heidelberg
Keywords: Peri-Implant Diseases in the Maxillofacial Region
Hyperglycemia
Prediabetes
Diabetes
Gingiva Index
Dental Plaque Index
Type 2 Diabetes
Published in: International Journal of Implant Dentistry / Issue 1/2020
Electronic ISSN: 2198-4034
DOI: https://doi.org/10.1186/s40729-020-00255-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Comparison of peri-implant soft tissue and crestal bone status of dental implants placed in prediabetic, type 2 diabetic, and non-diabetic individuals: a retrospective cohort study

Abstract

Background

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Results

Conclusion

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