Skip to main content
Top
Published in: World Journal of Emergency Surgery 1/2017

Open Access 01-12-2017 | Research article

Performance of imaging studies in patients with suspected appendicitis after stratification with adult appendicitis score

Authors: Henna E. Sammalkorpi, Ari Leppäniemi, Eila Lantto, Panu Mentula

Published in: World Journal of Emergency Surgery | Issue 1/2017

Login to get access

Abstract

Background

Diagnostic scoring is used to stratify patients with suspected appendicitis into three groups: high, intermediate, and low probability of appendicitis. The stratification can be used for selective imaging to avoid the harms of radiation without compromising diagnostic accuracy.
The aim was to study how stratification by Adult Appendicitis Score affects diagnostic performance of imaging studies.

Methods

Analysis of 822 patients who underwent diagnostic imaging for suspected appendicitis was made. Adult Appendicitis Score was used to stratify patients into groups of high, intermediate, and low probability of appendicitis. Diagnostic performance of computed tomography (CT) and ultrasound (US) was compared between these patient groups.

Results

After scoring, pre-test probability of appendicitis ranged from 9-16% in low probability group to 75-79% in high probability group in patients who underwent US or CT. Post-test probability of appendicitis after positive CT was 99, 91, and 75% in high probability, intermediate probability and low probability groups, respectively, p < 0.001. After positive US the respective probabilities were 95, 91 and 42%, p < 0.001.

Conclusion

Diagnostic imaging has limited value in patients with low probability of appendicitis according to Adult Appendicitis Score.
Literature
1.
go back to reference Boonstra PA, van Veen RN, Stockmann HB. Less negative appendectomies due to imaging in patients with suspected appendicitis. Surg Endosc. 2015;29:2365–70.CrossRefPubMed Boonstra PA, van Veen RN, Stockmann HB. Less negative appendectomies due to imaging in patients with suspected appendicitis. Surg Endosc. 2015;29:2365–70.CrossRefPubMed
2.
go back to reference Parker L, Nazarian LN, Gingold EL, Palit CD, Hoey CL, Frangos AJ. Cost and radiation savings of partial substitution of ultrasound for CT in appendicitis evaluation: a national projection. AJR Am J Roentgenol. 2014;202:124–35.CrossRefPubMed Parker L, Nazarian LN, Gingold EL, Palit CD, Hoey CL, Frangos AJ. Cost and radiation savings of partial substitution of ultrasound for CT in appendicitis evaluation: a national projection. AJR Am J Roentgenol. 2014;202:124–35.CrossRefPubMed
3.
go back to reference Kim K, Kim YH, Kim SY, et al. Low-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med. 2012;366:1596–605.CrossRefPubMed Kim K, Kim YH, Kim SY, et al. Low-dose abdominal CT for evaluating suspected appendicitis. N Engl J Med. 2012;366:1596–605.CrossRefPubMed
4.
go back to reference Atema JJ, Gans SL, Van Randen A, et al. Comparison of imaging strategies with conditional versus immediate contrast-enhanced computed tomography in patients with clinical suspicion of acute appendicitis. Eur Radiol. 2015;25:2445–52.CrossRefPubMedPubMedCentral Atema JJ, Gans SL, Van Randen A, et al. Comparison of imaging strategies with conditional versus immediate contrast-enhanced computed tomography in patients with clinical suspicion of acute appendicitis. Eur Radiol. 2015;25:2445–52.CrossRefPubMedPubMedCentral
5.
go back to reference Lahaye MJ, Lambergts DM, Mutsaers E, et al. Mandatory imaging cuts costs and reduces the rate of unnecessary surgeries in the diagnostic work-up of patients suspected of having appendicitis. Eur Radiol. 2015;25:1464.1470.CrossRef Lahaye MJ, Lambergts DM, Mutsaers E, et al. Mandatory imaging cuts costs and reduces the rate of unnecessary surgeries in the diagnostic work-up of patients suspected of having appendicitis. Eur Radiol. 2015;25:1464.1470.CrossRef
6.
go back to reference van Rossem CC, Bolmers MD, Schreinemacher MH, van Geloven AA, Bemelman WA, Snapshot Appendicitis Collaborative Study G. Prospective nationwide outcome audit of surgery for suspected acute appendicitis. Br J Surg. 2016;103:144–51.CrossRefPubMed van Rossem CC, Bolmers MD, Schreinemacher MH, van Geloven AA, Bemelman WA, Snapshot Appendicitis Collaborative Study G. Prospective nationwide outcome audit of surgery for suspected acute appendicitis. Br J Surg. 2016;103:144–51.CrossRefPubMed
7.
go back to reference Rogers W, Hoffman J, Noori N. Harms of CT scanning prior to surgery for suspected appendicitis. Evid Based Med. 2015;20:3–4.CrossRefPubMed Rogers W, Hoffman J, Noori N. Harms of CT scanning prior to surgery for suspected appendicitis. Evid Based Med. 2015;20:3–4.CrossRefPubMed
8.
go back to reference Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001;136:556–62.CrossRefPubMed Lee SL, Walsh AJ, Ho HS. Computed tomography and ultrasonography do not improve and may delay the diagnosis and treatment of acute appendicitis. Arch Surg. 2001;136:556–62.CrossRefPubMed
9.
go back to reference Sammalkorpi HE, Leppäniemi A, Mentula P. High admission C-reactive protein level and longer in-hospital delay to surgery are associated with increased risk of complicated appendicitis. Langenbecks Arch Surg Vol. 2015;400:221–8.CrossRef Sammalkorpi HE, Leppäniemi A, Mentula P. High admission C-reactive protein level and longer in-hospital delay to surgery are associated with increased risk of complicated appendicitis. Langenbecks Arch Surg Vol. 2015;400:221–8.CrossRef
10.
go back to reference Lehtimaki T, Juvonen P, Valtonen H, Miettinen P, Paajanen H, Vanninen R. Impact of routine contrast-enhanced CT on costs and use of hospital resources in patients with acute abdomen. Results of a randomised clinical trial. Eur Radiol. 2013;23:2538–45.CrossRefPubMed Lehtimaki T, Juvonen P, Valtonen H, Miettinen P, Paajanen H, Vanninen R. Impact of routine contrast-enhanced CT on costs and use of hospital resources in patients with acute abdomen. Results of a randomised clinical trial. Eur Radiol. 2013;23:2538–45.CrossRefPubMed
11.
go back to reference Pritchett CV, Levinsky NC, Ha YP, Dembe AE, Steinberg SM. Management of acute appendicitis: the impact of CT scanning on the bottom line. J Am Coll Surg. 2010;210(699–705):705–697. Pritchett CV, Levinsky NC, Ha YP, Dembe AE, Steinberg SM. Management of acute appendicitis: the impact of CT scanning on the bottom line. J Am Coll Surg. 2010;210(699–705):705–697.
12.
go back to reference Pinto F, Pinto A, Russo A, et al. Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature. Crit Ultrasound J. 2013;5 Suppl 1:S2.CrossRefPubMed Pinto F, Pinto A, Russo A, et al. Accuracy of ultrasonography in the diagnosis of acute appendicitis in adult patients: review of the literature. Crit Ultrasound J. 2013;5 Suppl 1:S2.CrossRefPubMed
13.
go back to reference van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA. Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology. 2008;249:97–106.CrossRefPubMed van Randen A, Bipat S, Zwinderman AH, Ubbink DT, Stoker J, Boermeester MA. Acute appendicitis: meta-analysis of diagnostic performance of CT and graded compression US related to prevalence of disease. Radiology. 2008;249:97–106.CrossRefPubMed
14.
go back to reference Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the alvarado score. World J Surg. 2008;32:1843–9.CrossRefPubMed Andersson M, Andersson RE. The appendicitis inflammatory response score: a tool for the diagnosis of acute appendicitis that outperforms the alvarado score. World J Surg. 2008;32:1843–9.CrossRefPubMed
15.
go back to reference Kollar D, McCartan DP, Bourke M, Cross KS, Dowdall J. Predicting acute appendicitis? a comparison of the alvarado score, the appendicitis inflammatory response score and clinical assessment. World J Surg. 2015;39:104–9.CrossRefPubMed Kollar D, McCartan DP, Bourke M, Cross KS, Dowdall J. Predicting acute appendicitis? a comparison of the alvarado score, the appendicitis inflammatory response score and clinical assessment. World J Surg. 2015;39:104–9.CrossRefPubMed
17.
go back to reference Di Saverio S, Birindelli A, Kelly MD, et al. WSES jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11:34.CrossRefPubMedPubMedCentral Di Saverio S, Birindelli A, Kelly MD, et al. WSES jerusalem guidelines for diagnosis and treatment of acute appendicitis. World J Emerg Surg. 2016;11:34.CrossRefPubMedPubMedCentral
18.
go back to reference Sammalkorpi H, Mentula P, Leppäniemi A, Sammalkorpi H, Mentula P, Leppäniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014;14:114.CrossRefPubMedPubMedCentral Sammalkorpi H, Mentula P, Leppäniemi A, Sammalkorpi H, Mentula P, Leppäniemi A. A new adult appendicitis score improves diagnostic accuracy of acute appendicitis--a prospective study. BMC Gastroenterol. 2014;14:114.CrossRefPubMedPubMedCentral
19.
go back to reference Sammalkorpi H, Mentula P, Savolainen H, Leppäniemi A. The introduction of Adult Appendicitis Score reduced negative appendectomy rate. Scandinavian Journal of Surgery. 2016 in press Sammalkorpi H, Mentula P, Savolainen H, Leppäniemi A. The introduction of Adult Appendicitis Score reduced negative appendectomy rate. Scandinavian Journal of Surgery. 2016 in press
20.
go back to reference Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007;31:86–92.CrossRefPubMed Andersson RE. The natural history and traditional management of appendicitis revisited: spontaneous resolution and predominance of prehospital perforations imply that a correct diagnosis is more important than an early diagnosis. World J Surg. 2007;31:86–92.CrossRefPubMed
21.
go back to reference Di Saverio S, Birindelli A, Piccinini A, Catena F, Biscardi A, Tugnoli G. How reliable is alvarado score and its subgroups in ruling Out acute appendicitis and suggesting the opportunity of nonoperative management or surgery? Ann Surg. 2016. doi:10.1097/sla.0000000000001548. Di Saverio S, Birindelli A, Piccinini A, Catena F, Biscardi A, Tugnoli G. How reliable is alvarado score and its subgroups in ruling Out acute appendicitis and suggesting the opportunity of nonoperative management or surgery? Ann Surg. 2016. doi:10.​1097/​sla.​0000000000001548​.
22.
go back to reference Ciani S, Chuaqui B. Histological features of resolving acute, non-complicated phlegmonous appendicitis. Pathol Res Pract. 2000;196:89–93.CrossRefPubMed Ciani S, Chuaqui B. Histological features of resolving acute, non-complicated phlegmonous appendicitis. Pathol Res Pract. 2000;196:89–93.CrossRefPubMed
23.
go back to reference Cobben LP, de Van Otterloo AM, Puylaert JB. Spontaneously resolving appendicitis: frequency and natural history in 60 patients. Radiology. 2000;215:349–52.CrossRefPubMed Cobben LP, de Van Otterloo AM, Puylaert JB. Spontaneously resolving appendicitis: frequency and natural history in 60 patients. Radiology. 2000;215:349–52.CrossRefPubMed
25.
go back to reference Decadt B, Sussman L, Lewis MP, et al. Randomized clinical trial of early laparoscopy in the management of acute non-specific abdominal pain. Br J Surg. 1999;86:1383–6.CrossRefPubMed Decadt B, Sussman L, Lewis MP, et al. Randomized clinical trial of early laparoscopy in the management of acute non-specific abdominal pain. Br J Surg. 1999;86:1383–6.CrossRefPubMed
26.
go back to reference Morino M, Pellegrino L, Castagna E, Farinella E, Mao P. Acute nonspecific abdominal pain: a randomized, controlled trial comparing early laparoscopy versus clinical observation. Ann Surg. 2006;244:881–6. discussion 886–888.CrossRefPubMedPubMedCentral Morino M, Pellegrino L, Castagna E, Farinella E, Mao P. Acute nonspecific abdominal pain: a randomized, controlled trial comparing early laparoscopy versus clinical observation. Ann Surg. 2006;244:881–6. discussion 886–888.CrossRefPubMedPubMedCentral
27.
go back to reference Andersson RE. Resolving appendicitis is common: further evidence. Ann Surg. 2008;247:553. author reply 553.CrossRefPubMed Andersson RE. Resolving appendicitis is common: further evidence. Ann Surg. 2008;247:553. author reply 553.CrossRefPubMed
28.
go back to reference Rao PM, Rhea JT, Rattner DW, Venus LGAS, Novelline RA. Introduction of appendiceal CT: impact on negative appendectomy and appendiceal perforation rates. Ann Surg. 1999;229:344–9.CrossRefPubMedPubMedCentral Rao PM, Rhea JT, Rattner DW, Venus LGAS, Novelline RA. Introduction of appendiceal CT: impact on negative appendectomy and appendiceal perforation rates. Ann Surg. 1999;229:344–9.CrossRefPubMedPubMedCentral
29.
go back to reference Ito K, Ito H, Whang EE, Tavakkolizadeh A. Appendectomy in pregnancy: evaluation of the risks of a negative appendectomy. Am J Surg. 2012;203:145–50.CrossRefPubMed Ito K, Ito H, Whang EE, Tavakkolizadeh A. Appendectomy in pregnancy: evaluation of the risks of a negative appendectomy. Am J Surg. 2012;203:145–50.CrossRefPubMed
30.
go back to reference McGory ML, Zingmond DS, Tillou A, Hiatt JR, Ko CY, Cryer HM. Negative appendectomy in pregnant women is associated with a substantial risk of fetal loss. J Am Coll Surg. 2007;205:534–40.CrossRefPubMed McGory ML, Zingmond DS, Tillou A, Hiatt JR, Ko CY, Cryer HM. Negative appendectomy in pregnant women is associated with a substantial risk of fetal loss. J Am Coll Surg. 2007;205:534–40.CrossRefPubMed
31.
go back to reference Konrad J, Grand D, Lourenco A. MRI: first-line imaging modality for pregnant patients with suspected appendicitis. Abdom Imaging. 2015;40:3359–64.CrossRefPubMed Konrad J, Grand D, Lourenco A. MRI: first-line imaging modality for pregnant patients with suspected appendicitis. Abdom Imaging. 2015;40:3359–64.CrossRefPubMed
Metadata
Title
Performance of imaging studies in patients with suspected appendicitis after stratification with adult appendicitis score
Authors
Henna E. Sammalkorpi
Ari Leppäniemi
Eila Lantto
Panu Mentula
Publication date
01-12-2017
Publisher
BioMed Central
Published in
World Journal of Emergency Surgery / Issue 1/2017
Electronic ISSN: 1749-7922
DOI
https://doi.org/10.1186/s13017-017-0119-4

Other articles of this Issue 1/2017

World Journal of Emergency Surgery 1/2017 Go to the issue