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Neuroradiology

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01-06-2009 | Diagnostic Neuroradiology

Performance of a new quantitative method for assessing dural ectasia in patients with FBN1 mutations and clinical features of Marfan syndrome

Authors: Bahar Söylen, Kerstin Hinz, Jana Prokein, Hartmut Becker, Jörg Schmidtke, Mine Arslan-Kirchner

Published in: Neuroradiology | Issue 6/2009

Abstract

Introduction

This study presents a comparison of established methods for measuring dural ectasia with a new quantitative method of assessing this clinical feature.

Methods

Seventeen patients with an identified mutation in FBN1 were examined for dural ectasia. The results were compared with 17 age- and sex-matched controls. Our images were also evaluated using the two methods of quantifying dural ectasia, namely those of Ahn et al. and of Oosterhof et al.

Results

With our method, 80% MFS1 patients and 7% controls fulfilled the criterion for dural ectasia. Using the method of Oosterhof et al., dural ectasia was found in 88% patients with MFS1 and in 47% controls. Using the method of Ahn et al. 76% patients with Marfan syndrome and 29% controls showed dural ectasia.

Conclusion

We present a novel quantitative method of evaluating MRT images for dural ectasia, which, in our own patient cohort, performed better than those previously described.

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Title: Performance of a new quantitative method for assessing dural ectasia in patients with FBN1 mutations and clinical features of Marfan syndrome
Authors: Bahar Söylen
Kerstin Hinz
Jana Prokein
Hartmut Becker
Jörg Schmidtke
Mine Arslan-Kirchner
Publication date: 01-06-2009
Publisher: Springer-Verlag
Published in: Neuroradiology / Issue 6/2009
Print ISSN: 0028-3940
Electronic ISSN: 1432-1920
DOI: https://doi.org/10.1007/s00234-009-0508-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Performance of a new quantitative method for assessing dural ectasia in patients with FBN1 mutations and clinical features of Marfan syndrome

Abstract

Introduction

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

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