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01-09-2017 | Original Scientific Report

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

Authors: Kotaro Yamashita, Masayuki Watanabe, Shinji Mine, Takanori Kurogochi, Akihiko Okamura, Masaru Hayami, Yu Imamura

Published in: World Journal of Surgery | Issue 9/2017

Abstract

Background

The recurrence patterns and therapeutic outcomes of patients with recurrent esophageal cancer after curative esophagectomy are not fully understood.

Methods

Data on recurrence patterns and sites of recurrence in patients with recurrent esophageal cancer after curative esophagectomy from 2005 to 2015 were retrospectively analyzed. Time to recurrence after curative esophagectomy and survival after recurrence were compared among groups stratified by recurrence pattern and site. Multivariate analysis was performed to identify clinicopathological parameters influencing survival after recurrence.

Results

Of the 290 patients identified, a single pattern of recurrence occurred in 224 patients (77.2%) and a multiple pattern of recurrence occurred in 66 patients (22.8%). The most frequent recurrence pattern was lymph node in 173 patients (59.7%), followed by distant organ in 133 patients (45.9%). Median time to recurrence and median survival after recurrence of all patients were 228 and 327 days, respectively. Among patients with lymph node or lung recurrence, there were 5-year survivors after recurrence who underwent multimodal therapy. Multivariate analysis revealed that longer disease-free interval [hazard ratio (HR) 0.70, 95% confidence interval (95% CI) 0.52–0.93], single pattern of recurrence (HR 0.54, 95% CI 0.39–0.74), and curative treatment for recurrence (HR 0.17, 95% CI 0.10–0.28) were significantly associated with favorable prognosis.

Conclusions

Although the prognosis of recurrent esophageal cancer remains unfavorable, if multimodal treatment that includes local therapy was curative, prognosis could improve, especially in patients with lymph node or lung recurrence.

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Title: Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy
Authors: Kotaro Yamashita
Masayuki Watanabe
Shinji Mine
Takanori Kurogochi
Akihiko Okamura
Masaru Hayami
Yu Imamura
Publication date: 01-09-2017
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 9/2017
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-017-4024-5

At a glance: The STEP trials

Springer Medicine

Patterns and Outcomes of Recurrent Esophageal Cancer After Curative Esophagectomy

Abstract

Background

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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