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01-08-2012 | Original Article

Patterns and time of recurrence after complete resection of esophageal cancer

Authors: Masahiko Sugiyama, Masaru Morita, Rintaro Yoshida, Koji Ando, Akinori Egashira, Ohga Takefumi, Hiroshi Saeki, Eiji Oki, Yoshihiro Kakeji, Yoshihisa Sakaguchi, Yoshihiko Maehara

Published in: Surgery Today | Issue 8/2012

Abstract

Purpose

The results and outcomes of surgical resection for esophageal carcinoma have improved remarkably in recent years; however, recurrence still frequently develops, even after complete resection. The purpose of this study is to clarify the characteristics of recurrence in this patient population.

Methods

Among 208 patients, who underwent R0 resection for esophageal carcinoma, recurrence developed in 61. Clinical data were available for 56 of these patients, who were the subjects of this study. We evaluated the time, patterns, and treatment of recurrence in these patients.

Results

Recurrence developed within 1 and 2 years after esophagectomy in 71 and 84% of the patients, respectively, and was classified as loco-regional (54%), hematogenous (36%), or mixed type (10%). The prognosis of patients with loco-regional recurrence tended to be better than that of those with distant metastasis, although the difference was not significant (P = 0.088). Patients with recurrence treated by chemotherapy alone or multimodal therapy, such as radiation or surgery combined with systemic chemotherapy, survived significantly longer than those with untreatable recurrence (P = 0.016).

Conclusion

These findings reinforce the importance of careful follow-up for both loco-regional and hematogenous recurrence after esophagectomy, particularly during the first 2 years.

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Title: Patterns and time of recurrence after complete resection of esophageal cancer
Authors: Masahiko Sugiyama
Masaru Morita
Rintaro Yoshida
Koji Ando
Akinori Egashira
Ohga Takefumi
Hiroshi Saeki
Eiji Oki
Yoshihiro Kakeji
Yoshihisa Sakaguchi
Yoshihiko Maehara
Publication date: 01-08-2012
Publisher: Springer Japan
Published in: Surgery Today / Issue 8/2012
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-012-0133-9

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Patterns and time of recurrence after complete resection of esophageal cancer

Abstract

Purpose

Methods

Results

Conclusion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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