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Journal of Gastroenterology
Published in: Journal of Gastroenterology 9/2012

01-09-2012 | Original Article—Liver, Pancreas, and Biliary Tract

Patients with chronic hepatitis C express a high percentage of CD4+CXCR5+ T follicular helper cells

Authors: Junyan Feng, Xiaoli Hu, Hui Guo, Xiguang Sun, Juan Wang, Lijun Xu, Zhenyu Jiang, Bingchuan Xu, Junqi Niu, Yanfang Jiang

Published in: Journal of Gastroenterology | Issue 9/2012

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Abstract

Background

T follicular helper (TFH) cells are a subpopulation of T-helper cells which regulate humoral immune responses. The role of TFH cells in viral infection is unclear. This study examined the possible involvement of CD4+CXCR5+ TFH cells in chronic hepatitis C (HCV) infection.

Methods

The percentages of peripheral blood CD4+CXCR5+ TFH cells, inducible T-cell costimulator cells, and/or programmed death 1-positive CD4+CXCR5+ TFH cells in 39 HCV-infected patients, 12 patients with spontaneously resolved HCV infection (SR-HCV), and 12 healthy controls were characterized by flow cytometry analysis. The subjects’ serum HCV RNA loads and alanine aminotransferase and aspartate aminotransferase levels were measured. The potential association of the percentage of peripheral CD4+CXCR5+ TFH cells with clinical data was analyzed.

Results

Higher percentages of peripheral blood CD4+CXCR5+ TFH cells were found in SR-HCV and HCV-infected patients as compared with healthy controls. Interestingly, a statistically significant negative correlation was found between the percentage of CD4+CXCR5+ TFH cells and the HCV RNA load.

Conclusions

These data suggest that CD4+CXCR5+ TFH cells may participate in HCV-related immune responses. Increased TFH cells in peripheral blood may help to control HCV infection.
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Metadata
Title
Patients with chronic hepatitis C express a high percentage of CD4+CXCR5+ T follicular helper cells
Authors
Junyan Feng
Xiaoli Hu
Hui Guo
Xiguang Sun
Juan Wang
Lijun Xu
Zhenyu Jiang
Bingchuan Xu
Junqi Niu
Yanfang Jiang
Publication date
01-09-2012
Publisher
Springer Japan
Published in
Journal of Gastroenterology / Issue 9/2012
Print ISSN: 0944-1174
Electronic ISSN: 1435-5922
DOI
https://doi.org/10.1007/s00535-012-0568-1

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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