Skip to main content
Top
Published in: Immunity & Ageing 1/2009

Open Access 01-12-2009 | Review

Pathophysiology of age-related diseases

Authors: Giuseppina Campisi, Martina Chiappelli, Massimo De Martinis, Vito Franco, Lia Ginaldi, Rosario Guiglia, Federico Licastro, Domenico Lio

Published in: Immunity & Ageing | Issue 1/2009

Login to get access

Abstract

A Symposium regarding the Pathophysiology of Successful and Unsuccessful Ageing was held in Palermo, Italy on 7-8 April 2009. Three lectures from that Symposium by G. Campisi, L. Ginaldi and F. Licastro are here summarized. Ageing is a complex process which negatively impacts on the development of various bodily systems and its ability to function. A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Thus, a better understanding of the pathophysiology of age-related diseases is urgently required to improve our understanding of maintaining good health in the elderly and to program possible therapeutic intervention.
Literature
1.
go back to reference World, Health, Organization: Active Ageing: a Policy Framework. Geneva, Switzerland. 2002 World, Health, Organization: Active Ageing: a Policy Framework. Geneva, Switzerland. 2002
2.
go back to reference De Rossi SS, Slaughter YA: Oral changes in older patients: a clinician's guide. Quintessence Int. 2007, 38: 773-780. 10.1111/j.1741-2358.2005.00095_4.x.PubMed De Rossi SS, Slaughter YA: Oral changes in older patients: a clinician's guide. Quintessence Int. 2007, 38: 773-780. 10.1111/j.1741-2358.2005.00095_4.x.PubMed
3.
go back to reference Oral health related to general health in older people. Gerodontology. 2005, 22 (s1): 9-11. 10.1111/j.1741-2358.2005.00095_4.x. Oral health related to general health in older people. Gerodontology. 2005, 22 (s1): 9-11. 10.1111/j.1741-2358.2005.00095_4.x.
4.
go back to reference Nitschke I, Muller F: The impact of oral health on the quality of life in the elderly. Oral Health Prev Dent. 2004, 1: 271-275. Nitschke I, Muller F: The impact of oral health on the quality of life in the elderly. Oral Health Prev Dent. 2004, 1: 271-275.
5.
go back to reference Gonsalves WC, Wrightson AS, Henry RG: Common oral conditions in older persons. Am Fam Physician. 2008, 78: 845-852. 10.1111/j.1752-7325.2000.tb03337.x.PubMed Gonsalves WC, Wrightson AS, Henry RG: Common oral conditions in older persons. Am Fam Physician. 2008, 78: 845-852. 10.1111/j.1752-7325.2000.tb03337.x.PubMed
6.
go back to reference Ghezzi EM, Ship JA: Systemic diseases and their treatments in the elderly: impact on oral health. J Public Health Dent. 2000, 60: 289-296. 10.1111/j.1752-7325.2000.tb03337.x.CrossRefPubMed Ghezzi EM, Ship JA: Systemic diseases and their treatments in the elderly: impact on oral health. J Public Health Dent. 2000, 60: 289-296. 10.1111/j.1752-7325.2000.tb03337.x.CrossRefPubMed
7.
go back to reference Pankhurst CL: Candidosis (oropharyngeal). Clin Evid. 2006, 15: 1849-1863. 10.1016/j.exger.2007.06.006.PubMed Pankhurst CL: Candidosis (oropharyngeal). Clin Evid. 2006, 15: 1849-1863. 10.1016/j.exger.2007.06.006.PubMed
8.
go back to reference Franceschi C, Motta L, Motta M, Malaguarnera M, Capri M, Vasto S, Candore G, Caruso C: The extreme longevity: the state of the art in Italy. Exp Gerontol. 2008, 43: 45-52. 10.1542/pir.29-1-5.CrossRefPubMed Franceschi C, Motta L, Motta M, Malaguarnera M, Capri M, Vasto S, Candore G, Caruso C: The extreme longevity: the state of the art in Italy. Exp Gerontol. 2008, 43: 45-52. 10.1542/pir.29-1-5.CrossRefPubMed
9.
10.
go back to reference Ciancio SG: Medications' impact on oral health. Journal of the American Dental Association. 2004, 135: 1440-1448.CrossRefPubMed Ciancio SG: Medications' impact on oral health. Journal of the American Dental Association. 2004, 135: 1440-1448.CrossRefPubMed
11.
go back to reference Ginocchio D, Borghi E, Schindler A: Dysphagia assessment in the elderly. Nutritional Therapy & Metabolism. 2009, 27: 9-15. Ginocchio D, Borghi E, Schindler A: Dysphagia assessment in the elderly. Nutritional Therapy & Metabolism. 2009, 27: 9-15.
12.
go back to reference Porter SR, Hegarty A, Scully C: An update of the etiology and management of xerostomia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2004, 97: 28-46. 10.1016/j.tripleo.2003.07.010.CrossRefPubMed Porter SR, Hegarty A, Scully C: An update of the etiology and management of xerostomia. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2004, 97: 28-46. 10.1016/j.tripleo.2003.07.010.CrossRefPubMed
13.
go back to reference Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B: Squamous Cell Carcinoma Related Oncogene Regulates Angiogenesis through Vascular Endothelial Growth Factor-A. Ann Surg Oncol. 2004, 11: 530-534. 10.1245/ASO.2004.03.014.CrossRefPubMed Talbot SG, O-charoenrat P, Sarkaria IS, Ghossein R, Reddy P, Ngai I, Cordeiro CN, Wong RJ, Kris MG, Rusch VW, Singh B: Squamous Cell Carcinoma Related Oncogene Regulates Angiogenesis through Vascular Endothelial Growth Factor-A. Ann Surg Oncol. 2004, 11: 530-534. 10.1245/ASO.2004.03.014.CrossRefPubMed
14.
go back to reference Armitage GC: Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999, 4: 1-6. 10.1902/annals.1999.4.1.1.CrossRefPubMed Armitage GC: Development of a classification system for periodontal diseases and conditions. Ann Periodontol. 1999, 4: 1-6. 10.1902/annals.1999.4.1.1.CrossRefPubMed
15.
go back to reference Kuo LC, Polson AM, Kang T: Associations between periodontal diseases and systemic diseases: a review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosis. Public health. 2008, 122: 417-433. 10.1016/j.puhe.2007.07.004.CrossRefPubMed Kuo LC, Polson AM, Kang T: Associations between periodontal diseases and systemic diseases: a review of the inter-relationships and interactions with diabetes, respiratory diseases, cardiovascular diseases and osteoporosis. Public health. 2008, 122: 417-433. 10.1016/j.puhe.2007.07.004.CrossRefPubMed
16.
go back to reference Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K: Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007, 13: 3-10. 10.1111/j.1469-0691.2007.01798.x.CrossRefPubMed Seymour GJ, Ford PJ, Cullinan MP, Leishman S, Yamazaki K: Relationship between periodontal infections and systemic disease. Clin Microbiol Infect. 2007, 13: 3-10. 10.1111/j.1469-0691.2007.01798.x.CrossRefPubMed
17.
go back to reference Jeffcoat MK, Lewis CE, Reddy MS, Wang CY, Redford M: Post-menopausal bone loss and its relationship to oral bone loss. Periodontol. 2000, 23: 94-102. 10.1034/j.1600-0757.2000.2230109.x.CrossRef Jeffcoat MK, Lewis CE, Reddy MS, Wang CY, Redford M: Post-menopausal bone loss and its relationship to oral bone loss. Periodontol. 2000, 23: 94-102. 10.1034/j.1600-0757.2000.2230109.x.CrossRef
18.
go back to reference Jonasson G, Bankvall G, Kiliaridis S: Estimation of skeletal bone mineral density by means of the trabecular pattern of the alveolar bone, its interdental thickness, and the bone mass of the mandible. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2001, 92: 346-352. 10.1067/moe.2001.116494.CrossRefPubMed Jonasson G, Bankvall G, Kiliaridis S: Estimation of skeletal bone mineral density by means of the trabecular pattern of the alveolar bone, its interdental thickness, and the bone mass of the mandible. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2001, 92: 346-352. 10.1067/moe.2001.116494.CrossRefPubMed
20.
go back to reference Riviere GR, Riviere KH, Smith KS: Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol. 2002, 17: 113-118. 10.1046/j.0902-0055.2001.00100.x.CrossRefPubMed Riviere GR, Riviere KH, Smith KS: Molecular and immunological evidence of oral Treponema in the human brain and their association with Alzheimer's disease. Oral Microbiol Immunol. 2002, 17: 113-118. 10.1046/j.0902-0055.2001.00100.x.CrossRefPubMed
21.
go back to reference Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN: The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol. 2001, 115: 91-100. 10.1016/S0165-5728(01)00270-3.CrossRefPubMed Romeo HE, Tio DL, Rahman SU, Chiappelli F, Taylor AN: The glossopharyngeal nerve as a novel pathway in immune-to-brain communication: relevance to neuroimmune surveillance of the oral cavity. J Neuroimmunol. 2001, 115: 91-100. 10.1016/S0165-5728(01)00270-3.CrossRefPubMed
23.
go back to reference Bohatschek M, Werner A, Raivich G: Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency. Exp Neurol. 2001, 172: 137-152. 10.1006/exnr.2001.7764.CrossRefPubMed Bohatschek M, Werner A, Raivich G: Systemic LPS injection leads to granulocyte influx into normal and injured brain: effects of ICAM-1 deficiency. Exp Neurol. 2001, 172: 137-152. 10.1006/exnr.2001.7764.CrossRefPubMed
24.
go back to reference Farrall AJ, Wardlaw JM: Blood-brain barrier: Ageing and microvascular disease - systematic review and metaanalysis. Neurobiol Aging. 2009, 30: 337-52. 10.1016/j.neurobiolaging.2007.07.015.CrossRefPubMed Farrall AJ, Wardlaw JM: Blood-brain barrier: Ageing and microvascular disease - systematic review and metaanalysis. Neurobiol Aging. 2009, 30: 337-52. 10.1016/j.neurobiolaging.2007.07.015.CrossRefPubMed
25.
go back to reference Chalmers JM, Carter KD, Spencer AJ: Oral diseases and conditions in community-living older adults with and without dementia. Spec Care Dentist. 2003, 23: 7-17. 10.1111/j.1754-4505.2003.tb00283.x.CrossRefPubMed Chalmers JM, Carter KD, Spencer AJ: Oral diseases and conditions in community-living older adults with and without dementia. Spec Care Dentist. 2003, 23: 7-17. 10.1111/j.1754-4505.2003.tb00283.x.CrossRefPubMed
26.
go back to reference Chalmers JM, Hodge C, Fuss JM, Spencer AJ, Carter KD: The prevalence and experience of oral diseases in Adelaide nursing home residents. Australian dental journal. 2002, 47: 123-130. 10.1111/j.1834-7819.2002.tb00315.x.CrossRefPubMed Chalmers JM, Hodge C, Fuss JM, Spencer AJ, Carter KD: The prevalence and experience of oral diseases in Adelaide nursing home residents. Australian dental journal. 2002, 47: 123-130. 10.1111/j.1834-7819.2002.tb00315.x.CrossRefPubMed
27.
go back to reference Gordon SR: Survey of dental need among veterans with severe cognitive impairment. Gerodontics. 1988, 4: 158-159.PubMed Gordon SR: Survey of dental need among veterans with severe cognitive impairment. Gerodontics. 1988, 4: 158-159.PubMed
28.
go back to reference Gordon SR, McLain D: Dental needs related to primary cause for institutionalization. Spec Care Dentist. 1991, 11: 49-54. 10.1111/j.1754-4505.1991.tb00813.x.CrossRefPubMed Gordon SR, McLain D: Dental needs related to primary cause for institutionalization. Spec Care Dentist. 1991, 11: 49-54. 10.1111/j.1754-4505.1991.tb00813.x.CrossRefPubMed
29.
go back to reference Jette AM, Feldman HA, Douglass C: Oral disease and physical disability in community-dwelling older persons. J Am Geriatr Soc. 1993, 41: 1102-1108.CrossRefPubMed Jette AM, Feldman HA, Douglass C: Oral disease and physical disability in community-dwelling older persons. J Am Geriatr Soc. 1993, 41: 1102-1108.CrossRefPubMed
30.
go back to reference Jones JA, Lavallee N, Alman J, Sinclair C, Garcia RI: Caries incidence in patients with dementia. Gerodontology. 1993, 10: 76-82. 10.1111/j.1741-2358.1993.tb00086.x.CrossRefPubMed Jones JA, Lavallee N, Alman J, Sinclair C, Garcia RI: Caries incidence in patients with dementia. Gerodontology. 1993, 10: 76-82. 10.1111/j.1741-2358.1993.tb00086.x.CrossRefPubMed
31.
go back to reference Ship JA, Puckett SA: Longitudinal study on oral health in subjects with Alzheimer's disease. J Am Geriatr Soc. 1994, 42: 57-63.CrossRefPubMed Ship JA, Puckett SA: Longitudinal study on oral health in subjects with Alzheimer's disease. J Am Geriatr Soc. 1994, 42: 57-63.CrossRefPubMed
32.
go back to reference Stein PS, Desrosiers M, Donegan SJ, Yepes JF, Kryscio RJ: Tooth loss, dementia and neuropathology in the Nun Study. Journal of the American Dental Association. 2007, 138: 1314-1322.CrossRefPubMed Stein PS, Desrosiers M, Donegan SJ, Yepes JF, Kryscio RJ: Tooth loss, dementia and neuropathology in the Nun Study. Journal of the American Dental Association. 2007, 138: 1314-1322.CrossRefPubMed
33.
go back to reference Dawson-Hughes B, Tosteson AN, Melton LJ, Baim S, Favus MJ, Khosla S, Lindsay RL: Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int. 2008, 19: 449-458. 10.1007/s00198-008-0559-5.CrossRefPubMed Dawson-Hughes B, Tosteson AN, Melton LJ, Baim S, Favus MJ, Khosla S, Lindsay RL: Implications of absolute fracture risk assessment for osteoporosis practice guidelines in the USA. Osteoporos Int. 2008, 19: 449-458. 10.1007/s00198-008-0559-5.CrossRefPubMed
34.
go back to reference Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi' F, Scola L, Vasto S, Caruso C: Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res. 2008, 11: 425-432. 10.1089/rej.2008.0662.CrossRefPubMed Candore G, Balistreri CR, Colonna-Romano G, Grimaldi MP, Lio D, Listi' F, Scola L, Vasto S, Caruso C: Immunosenescence and anti-immunosenescence therapies: the case of probiotics. Rejuvenation Res. 2008, 11: 425-432. 10.1089/rej.2008.0662.CrossRefPubMed
35.
go back to reference Datta HK, Ng WF, Walker JA, Tuck SP, Varanasi SS: The cell biology of bone metabolism. J Clin Pathol. 2008, 61: 577-587. 10.1136/jcp.2007.048868.CrossRefPubMed Datta HK, Ng WF, Walker JA, Tuck SP, Varanasi SS: The cell biology of bone metabolism. J Clin Pathol. 2008, 61: 577-587. 10.1136/jcp.2007.048868.CrossRefPubMed
36.
go back to reference McHugh KP: Osteoimmunology in skeletal cell biology and disease. Autoimmunity. 2008, 41: 181-182. 10.1080/08916930701694808.CrossRefPubMed McHugh KP: Osteoimmunology in skeletal cell biology and disease. Autoimmunity. 2008, 41: 181-182. 10.1080/08916930701694808.CrossRefPubMed
37.
38.
go back to reference Nakashima T, Takayanagi H: The dynamic interplay between osteoclasts and the immune system. Arch Biochem Biophys. 2008, 473: 166-171. 10.1016/j.abb.2008.04.004.CrossRefPubMed Nakashima T, Takayanagi H: The dynamic interplay between osteoclasts and the immune system. Arch Biochem Biophys. 2008, 473: 166-171. 10.1016/j.abb.2008.04.004.CrossRefPubMed
40.
go back to reference De Martinis M, Di Benedetto MC, Mengoli LP, Ginaldi L: Senile osteoporosis: is it an immune-mediated disease?. Inflamm Res. 2006, 55: 399-404. 10.1007/s00011-006-6034-x.CrossRefPubMed De Martinis M, Di Benedetto MC, Mengoli LP, Ginaldi L: Senile osteoporosis: is it an immune-mediated disease?. Inflamm Res. 2006, 55: 399-404. 10.1007/s00011-006-6034-x.CrossRefPubMed
41.
go back to reference Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M: The immune system in extreme longevity. Exp Gerontol. 2008, 43: 61-65. 10.1016/j.exger.2007.06.008.CrossRefPubMed Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini G, Passeri G, Monti D, Franceschi C, Passeri M: The immune system in extreme longevity. Exp Gerontol. 2008, 43: 61-65. 10.1016/j.exger.2007.06.008.CrossRefPubMed
42.
go back to reference McClung MRLE, Cohen SB, Bolognese MA, Woodson GC, Moffett AH, Peacock M, Miller PD, Lederman SN, Chesnut CH, Lain D, Kivitz AJ, Holloway DL, Zhang C, Peterson MC, Bekker PJ, AMG 162 Bone Loss Study Group: Denosumab in postmenopausal women with low bone mineral density. The New England journal of medicine. 2006, 354: 821-831. 10.1056/NEJMoa044459.CrossRefPubMed McClung MRLE, Cohen SB, Bolognese MA, Woodson GC, Moffett AH, Peacock M, Miller PD, Lederman SN, Chesnut CH, Lain D, Kivitz AJ, Holloway DL, Zhang C, Peterson MC, Bekker PJ, AMG 162 Bone Loss Study Group: Denosumab in postmenopausal women with low bone mineral density. The New England journal of medicine. 2006, 354: 821-831. 10.1056/NEJMoa044459.CrossRefPubMed
43.
go back to reference Ellis GKBH, Chlebowski R, Paul D, Spadafora S, Smith J, Fan M, Jun S: Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer. J Clin Oncol. 2008, 26: 4859-4861. 10.1200/JCO.2008.18.0851.CrossRef Ellis GKBH, Chlebowski R, Paul D, Spadafora S, Smith J, Fan M, Jun S: Randomized trial of denosumab in patients receiving adjuvant aromatase inhibitors for nonmetastatic breast cancer. J Clin Oncol. 2008, 26: 4859-4861. 10.1200/JCO.2008.18.0851.CrossRef
44.
go back to reference Candore G, Balistreri CR, Caruso M, Grimaldi MP, Incalcaterra E, Listì F, Vasto S, Caruso C: Pharmacogenomics: a tool to prevent and cure coronary heart disease. Curr Pharm Des. 2007, 13 (36): 3726-3734. 10.2174/138161207783018617.CrossRefPubMed Candore G, Balistreri CR, Caruso M, Grimaldi MP, Incalcaterra E, Listì F, Vasto S, Caruso C: Pharmacogenomics: a tool to prevent and cure coronary heart disease. Curr Pharm Des. 2007, 13 (36): 3726-3734. 10.2174/138161207783018617.CrossRefPubMed
45.
go back to reference Vasto S, Candore G, Duro G, Lio D, Grimaldi MP, Caruso C: Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics. 2007, 8: 1735-1745. 10.2217/14622416.8.12.1735.CrossRefPubMed Vasto S, Candore G, Duro G, Lio D, Grimaldi MP, Caruso C: Alzheimer's disease and genetics of inflammation: a pharmacogenomic vision. Pharmacogenomics. 2007, 8: 1735-1745. 10.2217/14622416.8.12.1735.CrossRefPubMed
46.
go back to reference Chiappelli M, Tumini E, Porcellini E, Licastro F: Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies. Expert review of neurotherapeutics. 2006, 6: 1327-1336. 10.1586/14737175.6.9.1327.CrossRefPubMed Chiappelli M, Tumini E, Porcellini E, Licastro F: Impaired regulation of immune responses in cognitive decline and Alzheimer's disease: lessons from genetic association studies. Expert review of neurotherapeutics. 2006, 6: 1327-1336. 10.1586/14737175.6.9.1327.CrossRefPubMed
47.
go back to reference Licastro F: Genomics of immune molecules: early detection of cognitive decline and new therapeutic interventions. Expert Rev Neurotherapeutics. 2002, 2: 639-645. 10.1586/14737175.2.5.639.CrossRef Licastro F: Genomics of immune molecules: early detection of cognitive decline and new therapeutic interventions. Expert Rev Neurotherapeutics. 2002, 2: 639-645. 10.1586/14737175.2.5.639.CrossRef
48.
go back to reference Kullo IJ, Ding K: Mechanisms of disease: the genetic basis of coronary heart disease. Nat Clin Pract Cardiovasc Med. 2007, 4: 558-569. 10.1038/ncpcardio0982.CrossRefPubMed Kullo IJ, Ding K: Mechanisms of disease: the genetic basis of coronary heart disease. Nat Clin Pract Cardiovasc Med. 2007, 4: 558-569. 10.1038/ncpcardio0982.CrossRefPubMed
49.
go back to reference Kruskal JB: On the shortest spanning subtree of a graph and the traveling-salesman problem. Proceedings of the American Mathematical Society. 1956, 7: 48-50. 10.2307/2033241.CrossRef Kruskal JB: On the shortest spanning subtree of a graph and the traveling-salesman problem. Proceedings of the American Mathematical Society. 1956, 7: 48-50. 10.2307/2033241.CrossRef
50.
go back to reference Hamsten A, Eriksson P: Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. J Intern Med. 2008, 263: 538-552. 10.1111/j.1365-2796.2008.01958.x.CrossRefPubMed Hamsten A, Eriksson P: Identifying the susceptibility genes for coronary artery disease: from hyperbole through doubt to cautious optimism. J Intern Med. 2008, 263: 538-552. 10.1111/j.1365-2796.2008.01958.x.CrossRefPubMed
51.
go back to reference Buscema M, Grossi E: The semantic connectivity map: an adapting self-organizing knowledge discovery method in data bases. Experience in gastro-esophageal reflux disease. Int J Data Min Bioinformatics. 2008, 2: 362-404. 10.1504/IJDMB.2008.022159.CrossRef Buscema M, Grossi E: The semantic connectivity map: an adapting self-organizing knowledge discovery method in data bases. Experience in gastro-esophageal reflux disease. Int J Data Min Bioinformatics. 2008, 2: 362-404. 10.1504/IJDMB.2008.022159.CrossRef
52.
go back to reference Licastro F, Porcellini E, Chiappelli M, Forti P, Buscema M, Ravaglia G, Grossi E: Neurobiol Aging. 2008, (doi:10.1016/j.neurobiolaging.2008.03.019) Licastro F, Porcellini E, Chiappelli M, Forti P, Buscema M, Ravaglia G, Grossi E: Neurobiol Aging. 2008, (doi:10.1016/j.neurobiolaging.2008.03.019)
53.
go back to reference Caruso C, Candore G, Colonna-Romano G, Lio D, Franceschi C: Inflammation and life-span. Science. 2005, 307: 208-209. 10.1126/science.307.5707.208.CrossRefPubMed Caruso C, Candore G, Colonna-Romano G, Lio D, Franceschi C: Inflammation and life-span. Science. 2005, 307: 208-209. 10.1126/science.307.5707.208.CrossRefPubMed
54.
go back to reference Jirillo E, Candore G, Magrone T, Caruso C: A scientific approach to anti-ageing therapies: state of the art. Curr Pharm Des. 2008, 14: 2637-2642. 10.2174/138161208786264070.CrossRefPubMed Jirillo E, Candore G, Magrone T, Caruso C: A scientific approach to anti-ageing therapies: state of the art. Curr Pharm Des. 2008, 14: 2637-2642. 10.2174/138161208786264070.CrossRefPubMed
Metadata
Title
Pathophysiology of age-related diseases
Authors
Giuseppina Campisi
Martina Chiappelli
Massimo De Martinis
Vito Franco
Lia Ginaldi
Rosario Guiglia
Federico Licastro
Domenico Lio
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Immunity & Ageing / Issue 1/2009
Electronic ISSN: 1742-4933
DOI
https://doi.org/10.1186/1742-4933-6-12

Other articles of this Issue 1/2009

Immunity & Ageing 1/2009 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.