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Archives of Virology
Published in: Archives of Virology 1/2011

01-01-2011 | Original Article

Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks

Authors: J. L. Wasilenko, A. M. Arafa, A. A. Selim, M. K. Hassan, M. M. Aly, A. Ali, S. Nassif, E. Elebiary, A. Balish, A. Klimov, D. L. Suarez, D. E. Swayne, M. J. Pantin-Jackwood

Published in: Archives of Virology | Issue 1/2011

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Abstract

Domestic ducks have been implicated in the dissemination and evolution of H5N1 highly pathogenic avian influenza (HPAI) viruses. In this study, two H5N1 HPAI viruses belonging to clade 2.2.1 isolated in Egypt in 2007 and 2008 were analyzed for their pathogenicity in domestic Pekin ducks. Both viruses produced clinical signs and mortality, but the 2008 virus was more virulent, inducing early onset of neurological signs and killing all ducks with a mean death time (MDT) of 4.1 days. The 2007 virus killed 3/8 ducks with a MDT of 7 days. Full-genome sequencing and phylogenetic analysis were used to examine differences in the virus genes that might explain the differences observed in pathogenicity. The genomes differed in 49 amino acids, with most of the differences found in the hemagglutinin protein. This increase in pathogenicity in ducks observed with certain H5N1 HPAI viruses has implications for the control of the disease, since vaccinated ducks infected with highly virulent strains shed viruses for longer periods of time, perpetuating the virus in the environment and increasing the possibility of transmission to susceptible birds.
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Metadata
Title
Pathogenicity of two Egyptian H5N1 highly pathogenic avian influenza viruses in domestic ducks
Authors
J. L. Wasilenko
A. M. Arafa
A. A. Selim
M. K. Hassan
M. M. Aly
A. Ali
S. Nassif
E. Elebiary
A. Balish
A. Klimov
D. L. Suarez
D. E. Swayne
M. J. Pantin-Jackwood
Publication date
01-01-2011
Publisher
Springer Vienna
Published in
Archives of Virology / Issue 1/2011
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI
https://doi.org/10.1007/s00705-010-0813-y

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