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01-01-2011 | Original Article

Phylogenetic analysis of pandemic 2009 influenza A virus circulating in the South American region: genetic relationships and vaccine strain match

Authors: Natalia Goñi, Gonzalo Moratorio, Viviana Ramas, Leticia Coppola, Hector Chiparelli, Juan Cristina

Published in: Archives of Virology | Issue 1/2011

Abstract

The first influenza pandemic of this century was declared in April of 2009, with the emergence of a novel H1N1 influenza A virus strain (H1N1pdm). Understanding the evolution of H1N1pdm strains within the South American region is essential for studying global diversification, emergence and resistance, as well as determining vaccine efficacy. In order to gain insight into these matters, phylogenetic analysis was performed using 29 hemagglutinin (HA) gene sequences from H1N1pdm strains isolated in South America. The results of these studies revealed that clade 7 was the dominant H1N1pdm lineage in South America. None of the strains isolated in South America clustered together with the 2010 H1 vaccine strain. Amino acid substitutions P100S, S220T and I338V were found in almost all HAs of South American H1N1pdm strains.

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Title: Phylogenetic analysis of pandemic 2009 influenza A virus circulating in the South American region: genetic relationships and vaccine strain match
Authors: Natalia Goñi
Gonzalo Moratorio
Viviana Ramas
Leticia Coppola
Hector Chiparelli
Juan Cristina
Publication date: 01-01-2011
Publisher: Springer Vienna
Published in: Archives of Virology / Issue 1/2011
Print ISSN: 0304-8608
Electronic ISSN: 1432-8798
DOI: https://doi.org/10.1007/s00705-010-0825-7

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